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Protein

DNA mismatch repair protein Msh6

Gene

MSH6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1111 – 1118ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • isotype switching Source: GO_Central
  • maintenance of DNA repeat elements Source: GO_Central
  • mismatch repair Source: GO_Central
  • mitotic G2 DNA damage checkpoint Source: UniProtKB
  • negative regulation of DNA endoreduplication Source: UniProtKB
  • negative regulation of DNA recombination Source: GO_Central
  • positive regulation of B cell proliferation Source: UniProtKB
  • response to UV Source: GO_Central
  • somatic hypermutation of immunoglobulin genes Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein Msh6By similarity
Gene namesi
Name:MSH6By similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004369271 – 1337DNA mismatch repair protein Msh6Add BLAST1337

Proteomic databases

PaxDbiE1BYJ2

Expressioni

Gene expression databases

BgeeiENSGALG00000008957

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014551

Structurei

3D structure databases

SMRiE1BYJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 130PWWPPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0217 Eukaryota
COG0249 LUCA
OMAiTPMMAQY
OrthoDBiEOG091G018J

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
InterProiView protein in InterPro
IPR015536 DNA_mismatch_repair_MSH6_C
IPR007695 DNA_mismatch_repair_MutS-lik_N
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR016151 DNA_mismatch_repair_MutS_N
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
IPR000313 PWWP_dom
PANTHERiPTHR11361:SF31 PTHR11361:SF31, 1 hit
PfamiView protein in Pfam
PF01624 MutS_I, 1 hit
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PF00855 PWWP, 1 hit
PIRSFiPIRSF037677 DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SM00293 PWWP, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
SSF53150 SSF53150, 1 hit
SSF55271 SSF55271, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit
PS50812 PWWP, 1 hit

Sequencei

Sequence statusi: Complete.

E1BYJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSASNLSVI HEVLLVLLNH QRINLPYENL EASLSRMLFL SSFVQEVVQV
60 70 80 90 100
PIPCNVSANR SVSGVYSPGD LVWAKMEGYP WWPCLIYNHP TEGTIVRGKG
110 120 130 140 150
SSARIHVQFF DVSPTRGWVS IKYLRPYKGS SDREVLKGGM FYSMKPEIKK
160 170 180 190 200
AMELADDAMS KDKTKRLELA VCSEPSDTEE AEEEEMEQMS GSASGDSDDS
210 220 230 240 250
NSEEDVKGNK RVPNRGSAIK AKRRRVLDSD SDRDGSDVEF KPDVKEASSE
260 270 280 290 300
EASSGVDENE ATDVETDEES IEESPIKVPS KRKRGNVSKP SKRSSLENEH
310 320 330 340 350
SEAPKRAAPV SLEAKSKLTL FAAPENFESQ ANACSGGTNG FAAWEHEKLE
360 370 380 390 400
WLQEGKKKDA HRRRQNHPDY DPCTLYVPED YLNKCTPGMR RWWQLKSQNF
410 420 430 440 450
DAVICYKVGK FYELYHMDAV TGVNELGLIF MKGSWAHSGF PETAFGRFSA
460 470 480 490 500
ILVQKGYKIA RVEQTETPEM MEARCKATAH TTKFDKVVRR EICRIITKGT
510 520 530 540 550
QTYSIIDCDP TENHNKYLLC VKEKEDSSGQ RVYGVCFVDT SVGKFYVGQF
560 570 580 590 600
SDDRHCSRFR TLVAHYTPVQ VLFEKGNLTV DTQKILKGSL ISCIQEGLIS
610 620 630 640 650
GSQFWSASKT LKVLLEEEYF KENQNTESGC VLPSVIKSLT SESDSLGLTP
660 670 680 690 700
GENSELALSA LGGIVFYLKK CLIDQELLSL ANFEKYIPVD ADNAKTVSSS
710 720 730 740 750
NFFARTDRRM VLDGVTLMNL EVLQNGTNGT TEGTLLERID SCCTPFGKRL
760 770 780 790 800
LKQWLCAPLC NPTSINDRLD AVEDLLAVPA KLTEITEHLK KLPDLERLLS
810 820 830 840 850
KIHSIGSPLK SQNHPDSRAI FYEEIKYSKK KIADFLSALE GFKVMNEIVD
860 870 880 890 900
AMEEVASDFK SQVLKQLVTR KAKHPDGRFP DLSAELKRWD TAFDHNQARK
910 920 930 940 950
TGVITPKAGF DPDYDKALQD IKTVEEDFRT YLDKQRKLLG LKSVLYWGTG
960 970 980 990 1000
KNRYQMEIPE TATSRNLPEE YELKSTRKGY KRYWTKEIEK MLAELINAEE
1010 1020 1030 1040 1050
RRDAALKDCM RRLFYNFDKN SQDWQTAVQC IAVLDVLMSL ANYSQDGDGP
1060 1070 1080 1090 1100
LCRPVILLPV DSAPPFLELK NARHPCITKT FFGDDFIPND IVIGSKDEDG
1110 1120 1130 1140 1150
GSEASCVLVT GPNMGGKSTL MRQAGLLVIM AQLGCYVPAE VCRLTPIDRV
1160 1170 1180 1190 1200
FTRLGASDRI MSGESTFFVE LSETSSILQH ATEHSLVLVD ELGRGTATFD
1210 1220 1230 1240 1250
GTAIASAVVR ELAENIKCRT LFSTHYHSLV EDYSGSAAVR LGHMACMVEN
1260 1270 1280 1290 1300
ESEDPSQETI TFLYKFIEGA CPKSYGFNAA RLADIPEEII QKGHRKAKEF
1310 1320 1330
EKKTMSLRIF RFLCRVVDGV THDANAVGKL TTMLSHL
Length:1,337
Mass (Da):149,891
Last modified:June 26, 2013 - v2
Checksum:i812A3FC936697810
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003073 Genomic DNA No translation available.
UniGeneiGga.48951

Similar proteinsi

Entry informationi

Entry nameiMSH6_CHICK
AccessioniPrimary (citable) accession number: E1BYJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: June 26, 2013
Last modified: July 18, 2018
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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