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Entry version 64 (10 Apr 2019)
Sequence version 4 (10 Apr 2019)
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Protein
Submitted name:

Afadin, adherens junction formation factor

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-418990 Adherens junctions interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Afadin, adherens junction formation factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BYF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000011329 Expressed in 10 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1BYF5 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000018461

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1892 Eukaryota
ENOG410XR0S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155237

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BYF5

Database of Orthologous Groups

More...
OrthoDBi
23029at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350731

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit
cd15471 Myo5p-like_CBD_afadin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028842 Afadin
IPR037977 CBD_Afadin
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10398 PTHR10398, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00498 FHA, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00240 FHA, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E1BYF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENPVFSMFM LSLSVISSTL RLWKTNAIFY AVRFHNNVSS KLSYELLAIN
60 70 80 90 100
QTHWFFFLLF IFLQDLEFHG VMRFYFQDKA AGNFATKCIR VSSTATTQDV
110 120 130 140 150
IETLAEKFRP DMRMLSSPKY SLYEVHVSGE ERRLDVDEKP LVVQLNWNKD
160 170 180 190 200
DREGRFVLKN ENDTLPPKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK
210 220 230 240 250
RREKEALRQA SDKDDRLLHG DDIENSRLAA EVYKDMPETS FTRTISNPEV
260 270 280 290 300
VMKRRRQQKL EKRMQEFRSS DGRPDSGGTL RIYADSLKPN IPYKTILLST
310 320 330 340 350
TDTADFAVIE ALEKYGLEKE NPKDYCIARV ILPPGAQHSD DKGAKETILD
360 370 380 390 400
DDECPLQIFR EWPSDKGILV FQLKRRPPDY VPKKSKKIAD GKPLKGKERV
410 420 430 440 450
DGSGYGSCLP PEKLPYLVEL SPGRRNHFAY YNYHAYEDGS DSRDKPKLYR
460 470 480 490 500
LQLSVTEVGT EKFDDNSIQL FGPGIQPHHC DLTNMDGVVT VTPRNIDAET
510 520 530 540 550
YVEGQRISET TMLQSGMKVQ FGSSHVFKFV DPTQDHIITK RPIDASLMVK
560 570 580 590 600
GPRHKAGAVQ ETTFDLEGDV HSGTALPASK STSRLDGDRT SSASSTAERG
610 620 630 640 650
MVKPMIRIEQ QQDYRRQESR PQDTHGPELI LPASIEFRES SEDAFLSAII
660 670 680 690 700
NYTNSSTVHF KLSPTYVLYM TCRYVLSSQY RPDITPTERT HKVIAIVNKM
710 720 730 740 750
VNMMEGVIQE VDQVDQKQKN IAGALAFWMA NASELLNFIK QDRDLSRITV
760 770 780 790 800
DAQDVLAHLV QMAFKYLVHC LQSELNNYMP AFLDDPEENN PQRPKIDDVL
810 820 830 840 850
HTLTGAMSLL RRCRVNAALT IQLFSQLFHF INMWLFNRLV TAPDSGLCSH
860 870 880 890 900
YWGAIVRQQL GHIEAWAEKQ GLELAADCHL SRIVQATTLL TMDKYSHADV
910 920 930 940 950
PNINSTCFKL NSLQLQALLQ NYHCAPDEPL IPTELIENVV TVAENTADEL
960 970 980 990 1000
ARSDGREVQL EEDPDLQLPF LLPEDGYSCD VVRNVPSGLQ EFLDPLCQRG
1010 1020 1030 1040 1050
FCRLIPHTRS PGTWTIYFEG ADYESHLSHE NAELAQPLRK EPEIITVTLK
1060 1070 1080 1090 1100
KQNGMGLSIV AAKGAGQDKL GIYVKSVVKG GAADVDGRLA AGDQLLSVDG
1110 1120 1130 1140 1150
RSLVGLSQER AAELMTRTGS VVTLEVAKQG AIYHGLATLL NQPSPMMQRG
1160 1170 1180 1190 1200
KPRPKSEGFE LYNNSTQNGS PESPQLPWTE YSEPKKLPGD DRLMKNRADH
1210 1220 1230 1240 1250
RSSPNVANQP PSPGGKNAYA SGTTTKITSV STGNLCTEEQ TLPPRPEAYP
1260 1270 1280 1290 1300
IPTQTYTREY FTFPASKSQD RMGPAQSQWP NYEEKPQIQA ESNHSINTTM
1310 1320 1330 1340 1350
QRVARSQEEL RDKVFQPERN RLEVVIRKDI EYIDRKSDSD QWMNSSVDSS
1360 1370 1380 1390 1400
TSSQEHLNHT SKPVSPGSCL TKSGPGRWKT PATSQPTPVA VSQPIRTDLP
1410 1420 1430 1440 1450
PPPPPPPVHY AAEFDEPQMD LPLPPPPPPN QVGAQASSQV AAAERKKREE
1460 1470 1480 1490 1500
HQRWYEKEKA RLEEERERKR REQERKLGQM RSQPLIPPQP VVPPVSLQQV
1510 1520 1530 1540 1550
KSEKTSTFQR SQETVIRELQ PQQQPRTIER RDLQYITISK EELSSSDSLS
1560 1570 1580 1590 1600
PDPWKRDAKE KLEKQQQMHI VDMLSKEIQD LQNKPDRTAE ENDRLRKLML
1610 1620 1630 1640 1650
EWQFQKRLQE SKQKDEDDDE EEDDDVDTML IMQRLEAERR ARQTAVPAIS
1660 1670 1680 1690 1700
VLDLLQDEER RRQQQLEEMR KREAEDRARQ EEERRQQEEE RTRREAEEKR
1710 1720 1730 1740 1750
RQEEEYYNRL EAERRRQHDE AERRLLEPDE PGINSYTGSS GATVGAHEVY
1760 1770 1780 1790 1800
RDPRDKRSKS QDTDLPGAPE NLTFRERQRL FSQGQDVSNK VKASRKLMEL

ENELNTK
Length:1,807
Mass (Da):206,335
Last modified:April 10, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA74DD95AE302150
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5P8Z8A0A1D5P8Z8_CHICK
Afadin, adherens junction formation...
1,912Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5PJR8A0A1D5PJR8_CHICK
Afadin, adherens junction formation...
1,824Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5PSL2A0A1D5PSL2_CHICK
Afadin, adherens junction formation...
1,891Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5P7V5A0A1D5P7V5_CHICK
Afadin, adherens junction formation...
1,707Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000003 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000018484; ENSGALP00000018461; ENSGALG00000011329

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000003 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018461

Proteomic databases

PaxDbiE1BYF5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018484; ENSGALP00000018461; ENSGALG00000011329

Phylogenomic databases

eggNOGiKOG1892 Eukaryota
ENOG410XR0S LUCA
GeneTreeiENSGT00940000155237
InParanoidiE1BYF5
OrthoDBi23029at2759
TreeFamiTF350731

Enzyme and pathway databases

ReactomeiR-GGA-418990 Adherens junctions interactions

Gene expression databases

BgeeiENSGALG00000011329 Expressed in 10 organ(s), highest expression level in female gonad
ExpressionAtlasiE1BYF5 baseline

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15471 Myo5p-like_CBD_afadin, 1 hit
InterProiView protein in InterPro
IPR028842 Afadin
IPR037977 CBD_Afadin
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10398 PTHR10398, 2 hits
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00498 FHA, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 2 hits
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00240 FHA, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 2 hits
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BYF5_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BYF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: April 10, 2019
This is version 64 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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