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UniProtKB - E1BVQ3 (E1BVQ3_CHICK)

Entry version 69 (02 Dec 2020)
Sequence version 3 (30 Nov 2016)
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Protein

SEC7 domain-containing protein

Gene

ARFGEF2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation
Biological processProtein transportARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SEC7 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARFGEF2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E1BVQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSGALG00000004663, Expressed in liver and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9031.ENSGALP00000007416

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini643 – 832SEC7InterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 286DisorderedSequence analysisAdd BLAST21
Regioni328 – 355DisorderedSequence analysisAdd BLAST28
Regioni1521 – 1542DisorderedSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0929, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000691_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E1BVQ3

Database of Orthologous Groups

More...OrthoDBi		815698at2759

TreeFam database of animal gene trees

More...TreeFami		TF300714

Family and domain databases

Conserved Domains Database

More...CDDi		cd00171, Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR032629, DCB_dom
IPR015403, Sec7_C
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
IPR032691, Sec7_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16213, DCB, 1 hit
PF09324, DUF1981, 1 hit
PF01369, Sec7, 1 hit
PF12783, Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF48425, SSF48425, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50190, SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1BVQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPPAREQDA RTKSMFVSRA LEKILAEKEA KRPPHGQLRR ACQVALDEIK 
        60         70         80         90        100
TELEKQREGT VAPPKANFIE ADKYFLPFEL ACQSKSPRIV STSLDCLQKL 
       110        120        130        140        150
IAYGHITGNA PDSGAPGKRL IDRIVDTICN CFQGPQTDEG VQLQIIKALL 
       160        170        180        190        200
TAVTSPYIEI HEGTVLQTVR TCYNIYLASK NLINQTTAKA TLTQMLNVIF 
       210        220        230        240        250
TRMENQSVQE SREVGKTNQQ KSQSPAIQAV TRSPKMGQLK HHYQEGKCPA 
       260        270        280        290        300
PVSMELTNGE PERTGYGNMK SEQDLVPSAS EETTDGGKEM VKGILEDVVE 
       310        320        330        340        350
SAVKVAEEKQ VTEMAKALPA IETADTVLSG SSSENVQTNG ISDDGQSVSS 
       360        370        380        390        400
TDNLEADVSG HQAAAKFSHV LQKDAFLVFR SLCKLSMKPL GDGPPDPKSH 
       410        420        430        440        450
ELRSKIVSLQ LLLSVLQNAG PVFRTHEMFI NAIKQYLCVA LSKNGVSSVP 
       460        470        480        490        500
DVFELSLAIF LTLLSNFKTH LKMQIEVFFK EIFLNILETS SSSFEHKWMV 
       510        520        530        540        550
IQTLTRICAD AQCVVDIYVN YDCDLNAANI FERLVNDLSK IAQGRSGHEL 
       560        570        580        590        600
GMTPLQELSL RKKGLECLVS ILKCMVEWSK DLYVNPNHQT SLGTYKPSEQ 
       610        620        630        640        650
EIAEGKCLDG GGRRSSVSSL DSTVSSGVGS VGTQTAVPDD PEQFEVMKQQ 
       660        670        680        690        700
KEIIEHGIEL FNKKPKRGIQ YLQEQGMLGS TAEDIAQFLH QEERLCSTQA 
       710        720        730        740        750
GEFLGEGSKF NKEVMYAYVD QLDFCGKDFV SALRIFLEGF RLPGEAQKID 
       760        770        780        790        800
RLMEKFAARY IECNQRQTLF ASADTAYVLA YSIIMLTTDL HSPQVKNKMT 
       810        820        830        840        850
KEQYIKMNRG INDSKDLPVE YLSTIYEEIE GKKIAMKETK EYAITTKCSK 
       860        870        880        890        900
PSVANEKQRR LLYNLEMEQM AKTAKALMEA VSHAKAPFTS ATHLDHVRPM 
       910        920        930        940        950
FKLVWTPLLA AYSVGLQNCD DTEVASLCLE GIRCAIRIAC IFGMQLERDA 
       960        970        980        990       1000
YVQALARFSL LTASSSITEM KQKNIDTIKT LITVAHTDGN YLGNSWHEIL 
      1010       1020       1030       1040       1050
KCISQLELAQ LIGTGVKTRY LSGAGREREG IIKGYASGGE EFMGLGLGNL 
      1060       1070       1080       1090       1100
VGSGADKRHM ASIQESVGET SSQSVVVAVD RIFTGSTRLD GNAIVDFVRW 
      1110       1120       1130       1140       1150
LCAVSMDELA SPHHPRMFSL QKIVEISYYN MNRIRLQWSR IWQVIGDHFN 
      1160       1170       1180       1190       1200
KVGCNPNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF LRPFEHIMKK 
      1210       1220       1230       1240       1250
NRSPTIRDMV IRCIAQMVNS QAGNIRSGWK NIFAVFHQAA SDHDGNIVEL 
      1260       1270       1280       1290       1300
AFQTTAHIVT NIFQQHFPAA IDSFQDAVKC LSEFACNIAF PDTSMEAIRL 
      1310       1320       1330       1340       1350
IRYCAKYVSE RPQVLREYTS DDMNVAPGDR VWVRGWFPIL FELSCIINRC 
      1360       1370       1380       1390       1400
KLDVRTRGLT VMFEIMKSYG HTFEKHWWQD LFRIVFRIFD NMKLPEQQTE 
      1410       1420       1430       1440       1450
KSEWMTTTCN HALYAICDVF TQFYEALNEI LLPDILAQLH WCVKQENEQL 
      1460       1470       1480       1490       1500
ARSGTNCLEN LVILNGQKFS PEVWGQTCNC MLEIFKTTIP HVLLTWRPAG 
      1510       1520       1530       1540       1550
MEEDSAEKHL DLDLDRQSLS SVDKNASERG QSQLSNPTDE SWKGGPYTNQ 
      1560       1570       1580       1590       1600
KLFAGLLIKC VVQLELIQTI DNIVFYPATS KKEDAEHMAA AQRDALDADI 
      1610       1620       1630       1640       1650
HIDTEDQGMY KHMSSHHLFK LLDCLQESHS FSKAFNSNYE QRTVLWRAGF 
      1660       1670       1680       1690       1700
KGKSKPNLLK QETSSLACCL RILFRMYVDE NRRDSWDAIQ QRLLSVCSEA 
      1710       1720       1730       1740       1750
LAYFITVNSE SHREAWTNLL LLLLTKTLKI SDEKFKAHAS TYYPYLCEIM 
      1760       1770       1780       1790 
QFDLIPELRA VLRKFFLRIG VVFKICITEE QIRTTGTNLP SW
Length:1,792
Mass (Da):201,952
Last modified:November 30, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i744359C63315D3AD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AADN05000479 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_417388.3, XM_417388.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSGALT00000007428; ENSGALP00000007416; ENSGALG00000004663

Database of genes from NCBI RefSeq genomes

More...GeneIDi		419211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		gga:419211

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000479 Genomic DNA No translation available.
RefSeqiXP_417388.3, XM_417388.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007416

Proteomic databases

PaxDbiE1BVQ3

Genome annotation databases

EnsembliENSGALT00000007428; ENSGALP00000007416; ENSGALG00000004663
GeneIDi419211
KEGGigga:419211

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10564

Phylogenomic databases

eggNOGiKOG0929, Eukaryota
GeneTreeiENSGT00940000158950
HOGENOMiCLU_000691_1_0_1
InParanoidiE1BVQ3
OrthoDBi815698at2759
TreeFamiTF300714

Miscellaneous databases

Protein Ontology

More...PROi		PR:E1BVQ3

Gene expression databases

BgeeiENSGALG00000004663, Expressed in liver and 13 other tissues

Family and domain databases

CDDicd00171, Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR032629, DCB_dom
IPR015403, Sec7_C
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
IPR032691, Sec7_N
PfamiView protein in Pfam
PF16213, DCB, 1 hit
PF09324, DUF1981, 1 hit
PF01369, Sec7, 1 hit
PF12783, Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222, Sec7, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF48425, SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190, SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BVQ3_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BVQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 30, 2016
Last modified: December 2, 2020
This is version 69 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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