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Entry version 58 (11 Dec 2019)
Sequence version 4 (10 Apr 2019)
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Protein
Submitted name:

Arginine-glutamic acid dipeptide repeats

Gene

RERE

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Arginine-glutamic acid dipeptide repeatsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REREImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BVH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000002232 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000003489

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 275BAHInterPro annotationAdd BLAST173
Domaini276 – 379ELM2InterPro annotationAdd BLAST104
Domaini383 – 435SANTInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90DisorderedSequence analysisAdd BLAST90
Regioni456 – 487DisorderedSequence analysisAdd BLAST32
Regioni534 – 1118DisorderedSequence analysisAdd BLAST585
Regioni1162 – 1232DisorderedSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 38PolyampholyteSequence analysisAdd BLAST38
Compositional biasi50 – 75PolyampholyteSequence analysisAdd BLAST26
Compositional biasi456 – 478PolarSequence analysisAdd BLAST23
Compositional biasi548 – 563PolyampholyteSequence analysisAdd BLAST16
Compositional biasi597 – 618PolarSequence analysisAdd BLAST22
Compositional biasi619 – 662PolyampholyteSequence analysisAdd BLAST44
Compositional biasi663 – 677PolarSequence analysisAdd BLAST15
Compositional biasi678 – 701PolyampholyteSequence analysisAdd BLAST24
Compositional biasi702 – 741PolarSequence analysisAdd BLAST40
Compositional biasi742 – 757Pro-richSequence analysisAdd BLAST16
Compositional biasi773 – 796Pro-richSequence analysisAdd BLAST24
Compositional biasi804 – 818Pro-richSequence analysisAdd BLAST15
Compositional biasi819 – 834PolarSequence analysisAdd BLAST16
Compositional biasi835 – 865Pro-richSequence analysisAdd BLAST31
Compositional biasi866 – 884PolarSequence analysisAdd BLAST19
Compositional biasi899 – 937Pro-richSequence analysisAdd BLAST39
Compositional biasi980 – 1022PolarSequence analysisAdd BLAST43
Compositional biasi1023 – 1046Pro-richSequence analysisAdd BLAST24
Compositional biasi1047 – 1072PolarSequence analysisAdd BLAST26
Compositional biasi1162 – 1196PolyampholyteSequence analysisAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2133 Eukaryota
ENOG410ZIND LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BVH0

TreeFam database of animal gene trees

More...
TreeFami
TF328554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202 ZnF_GATA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03154 Atrophin-1, 1 hit
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1BVH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTADKEKDKD KEKDRDRDRD KERDKRDKVR ESENSRPRRS CTLEGGAKNY
60 70 80 90 100
AESDHSEDED NDNNSATTEE STKKSKKKPP KKKSRYERTD NGEITSFITE
110 120 130 140 150
DDVVYRPGDC VYIESRRPNT PYFICSIQDF KLVRNVFTSP PPPPFPHPSC
160 170 180 190 200
SEVQCLLVWG ERGGLRSKRD HLLMNVKWYY RQSEVPDSVY QHLVQDRHNE
210 220 230 240 250
NDSGRELVIT DPVIKNRELF ISDYVDTYHA AALRGKCNIS HFSDIFAARE
260 270 280 290 300
FKARVDSFFY ILGYNPETRR LNSTQGEIRV GPSHQAKLPD LQPFPSPDGD
310 320 330 340 350
TVTQHEELVW MPGVNDCDLL MYLRAARSMA AFAGMCDGGS TEDGCVAASR
360 370 380 390 400
DDTTLNALNT LHESNYDAGK ALQRLVKKPV PKLIEKCWTE DEVKRFIKGL
410 420 430 440 450
RQYGKNFFRI RKELLPNKET GELITFYYYW KKTPEAASSR AHRRHRRQAV
460 470 480 490 500
FRRIKTRTAS TPVNTPSRPP SSEFLDLSSA SEDDFDSEDS EQELKGYACR
510 520 530 540 550
HCFTTTSKDW HHGGRENILL CTDCRIHFKK YGELPPIEKP VDPPPFMFKP
560 570 580 590 600
VKEEDDGLSG KHSMRTRRSR GSMSTLRSGR KKQPASPDGR ASPINEDIRS
610 620 630 640 650
SGRNSPSAAS TSSNDSKADS VKKSTKKIKE EVSSPLKNSK RQREKAASDT
660 670 680 690 700
EEPERSSAKK SKTQEISRPN SPSEGEGEGE SSDSRSVNDE GSSDPKDIDQ
710 720 730 740 750
DNRSTSPSIP SPQDNESDSD SSAQQQVLQA QPQVLQAPSS SGQAPPPMPP
760 770 780 790 800
IPAQLPAPLP AASSASTAPP QVSPPASQAP SQPQAPAPPP PHSHIQQAPA
810 820 830 840 850
LHPQRLPSPH PPLQPLNASQ SQPAPASSQP HSQPPLHTQP QPAPHSLQAQ
860 870 880 890 900
PLLPHPVPPQ PFSLPTQSPQ SQVPLQTQAP SHSHSPALPA AAPLQQAQPP
910 920 930 940 950
REQPLPPAPM AMPHIKPPPT TPIPQLPTPP SHKHPPHLSG PSPFSMNSNL
960 970 980 990 1000
PPPPALKPLS SLSTHHPPSA HPPPLQLMPQ SQPLQSSQAQ PPVLTQSQSL
1010 1020 1030 1040 1050
PPSASHPPSG LHQVSSQPPF SQHPFVPGAP PSITSPSCPS TSTPPAVPGI
1060 1070 1080 1090 1100
PLQTSISTSA ASSGSVPVVT SCTLPPIQIK EEVPDEAEEP ESPPPPPRSP
1110 1120 1130 1140 1150
SPEPTVVDTP SHASQSARFY KHLDRGYNSC SRADLYFMPL AGSKLAKKRE
1160 1170 1180 1190 1200
EAIEKAKREA EQKAREERER EKEKEKERER EREREREAER AAKVSSSSHE
1210 1220 1230 1240 1250
GRLGESQLSG PAHMRPSFEP PPTTIAAVPP YIGPDTPALR TLSEYARPHV
1260 1270 1280 1290 1300
MSPTNRNHPF FVPLNPTDPL LAYHMPGLYN VDPTIREREL REREIREREI
1310 1320 1330 1340 1350
RERELRERMK PGFEVKPPEL DALHPATNPM EHFARHGALT IPPTAGPHPF
1360 1370 1380 1390 1400
ASFHPGLNPL ERERLALAGP QLRPEMSYPD RLAAERIHAE RMASLTNDPL
1410 1420 1430 1440 1450
ARLQMFNVTP HHHQHSHIHS HLHLHQQDPL HQGSAGPVHP LVDPLAAGPH
1460 1470 1480 1490 1500
LARFPYPPGT IPNPLLGQPP HEHEMLRHPV FGTPYPRDLP GAIPPPMSAA
1510 1520 1530 1540 1550
HQLQAMHAQS AELQRLAMEQ QWLHGHPHMH GGHLPSQEDY YSRLKKEGDK

QL
Length:1,552
Mass (Da):172,267
Last modified:April 10, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i565E5FBA256D437B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2TVQ1A0A3Q2TVQ1_CHICK
Arginine-glutamic acid dipeptide re...
RERE
569Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000197 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000003495; ENSGALP00000003489; ENSGALG00000002232

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000197 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003489

Proteomic databases

PaxDbiE1BVH0

Genome annotation databases

EnsembliENSGALT00000003495; ENSGALP00000003489; ENSGALG00000002232

Phylogenomic databases

eggNOGiKOG2133 Eukaryota
ENOG410ZIND LUCA
GeneTreeiENSGT00940000153615
InParanoidiE1BVH0
TreeFamiTF328554

Gene expression databases

BgeeiENSGALG00000002232 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF03154 Atrophin-1, 1 hit
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BVH0_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BVH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 58 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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