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Entry version 59 (10 Apr 2019)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

USPL1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C98.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USPL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BT05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000017079 Expressed in 11 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1BT05 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000027538

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini231 – 495USPInterPro annotationAdd BLAST265

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9P Eukaryota
ENOG410YB7R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002316

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BT05

KEGG Orthology (KO)

More...
KOi
K23008

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDGDCKK

Database of Orthologous Groups

More...
OrthoDBi
204698at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350670

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029388 DUF4650
IPR038765 Papain_like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1

The PANTHER Classification System

More...
PANTHERi
PTHR15294 PTHR15294, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1BT05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTQKTTNGL RVIGQGTGIG KSTLHMVGYL GKSHAPVEKT SPDYCPVCKE
60 70 80 90 100
KGQVQVLRTY RINFQESIYL CENPQCIYPL GYKPFNSIII SADSENLQVP
110 120 130 140 150
SYDKKRKLCD ISDLSPIESN PKQARTNNVV NVEQAINTDP VVKSCGDSLC
160 170 180 190 200
IPQSRVCDVL ENGQQKSNSE ESINQKVDFE TTSNTNGHQE SPPKNFSSRT
210 220 230 240 250
QLLPNSTHSS TASEVLLRDN NCSTNNTELC LQWRNKYNLC WLDCVLSALV
260 270 280 290 300
HLEALKFALV EEDDEKCLLQ RLLTKYSQAT VLLNTCKRGK VKDILPKAEL
310 320 330 340 350
LLNEIRNQIF IQLQPQLKCE LGKEESPVFA LPLLLKQDQH AEKLFSHSFS
360 370 380 390 400
WKFECMCCGY KYLDRCRKTL TTFTNIIPDW HPLNAVHVAP CNNCSDRSQR
410 420 430 440 450
RQMILEKVPS ILMFHFQEGL PHNKLKSYSF QLEEDVYQIT SVIQYAVHKK
460 470 480 490 500
HFITWSLNPD GTWLECDDLK GPYCRRHKRF EVPPTEIHIV IWEKKASRLP
510 520 530 540 550
EEQDSQYQSK NIEDSSTNNV QLKSTVLHCG FDDAVDNMLA EDHQEDTVRI
560 570 580 590 600
PDKKQQRVAE GESSARCGLE NLARDGLVTQ ILEETPLDSE GKSMLSRKMV
610 620 630 640 650
ENNLVVETGS QEKQESAFSP NTPCTGEFIA TDLAMNDKDM LSENSSMCLS
660 670 680 690 700
LQELNPASIT SSVPKKHDPN PSDSSLAQST GDRANLINGE HGLSSGQQIN
710 720 730 740 750
CELPPVENIV QKSPDLTGAS KTAVHSQVAS SSVDNNSFQP SDKDQKRGFV
760 770 780 790 800
GSWVKKLLSK NTSFLPSSAS LPKNERSCKT PSVQKLSDTW LPVKGASNFG
810 820 830 840 850
GFQGRGERKS SQTLTSVLPR SNNAQCLSKF QGFSQGTCLP RSHSAKEGPT
860 870 880 890 900
WNKSGNTQGG SGKTTQVHPP SCNSVKAEES DSDKTRKLRL KLLKKLNAKK
910 920 930 940 950
KKLASLDRLA VEQAKRGKPV ARDVSAPSQT ESHNDSELLQ SFLRELQYHI
960 970 980 990 1000
DAADNSSEFS VNSGCTSHNS NDEILAELLS PASTVASSEV PKSEDECMYM
1010 1020 1030 1040 1050
EMVNSSSAAP AEPAEKTSVS HAAVTSEDRS YYGPVKDSNY ERTVSKSSVK
1060 1070 1080 1090
KTGFESPTRE DILEDLFSIS APTTMAGDMD VPHFDETLFE TW
Length:1,092
Mass (Da):121,500
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEC4A3F9EFE08B1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1N926F1N926_CHICK
Uncharacterized protein
USPL1
737Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000588 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001155865.1, NM_001162393.2
XP_015133116.1, XM_015277630.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.4471

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000027590; ENSGALP00000027538; ENSGALG00000017079

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000588 Genomic DNA No translation available.
RefSeqiNP_001155865.1, NM_001162393.2
XP_015133116.1, XM_015277630.1
UniGeneiGga.4471

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027538

Protein family/group databases

MEROPSiC98.001

Proteomic databases

PaxDbiE1BT05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000027590; ENSGALP00000027538; ENSGALG00000017079
GeneIDi395436
KEGGigga:395436

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10208

Phylogenomic databases

eggNOGiENOG410IJ9P Eukaryota
ENOG410YB7R LUCA
GeneTreeiENSGT00390000002316
InParanoidiE1BT05
KOiK23008
OMAiKDGDCKK
OrthoDBi204698at2759
TreeFamiTF350670

Gene expression databases

BgeeiENSGALG00000017079 Expressed in 11 organ(s), highest expression level in spleen
ExpressionAtlasiE1BT05 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029388 DUF4650
IPR038765 Papain_like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1
PANTHERiPTHR15294 PTHR15294, 1 hit
PfamiView protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BT05_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BT05
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: June 26, 2013
Last modified: April 10, 2019
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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