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Protein
Submitted name:

Rap guanine nucleotide exchange factor 1

Gene

RAPGEF1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-GGA-170968 Frs2-mediated activation
R-GGA-186763 Downstream signal transduction
R-GGA-8875555 MET activates RAP1 and RAC1
R-GGA-912631 Regulation of signaling by CBL

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factor 1Imported
Gene namesi
Name:RAPGEF1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000003712

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 799N-terminal Ras-GEFInterPro annotationAdd BLAST124
Domaini810 – 1034Ras-GEFInterPro annotationAdd BLAST225

Phylogenomic databases

GeneTreeiENSGT00910000143985
InParanoidiE1BS61
OrthoDBiEOG091G03MV
TreeFamiTF317296

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

E1BS61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QDTNSERSHL SSFTMKLKGK FHSPKIKRTP SKKGKQADLT VKTPEKSANK
60 70 80 90 100
VSKWRASSPR LAGFLLSVTQ VLRSTASLSN LSWLEEKEKE VVSALRYFKT
110 120 130 140 150
IVDKMAIDKK VLEMLPGSAS KVLEAILPLV QSDPRIQQSS AISSCYSRVY
160 170 180 190 200
QSLANLIRWS DQVMLEGVNS EDKEMVTTVK DVIKAVLDGV KELVKLTIEK
210 220 230 240 250
QEHPSPTSPV KPSLPACKSD SPSELPLTDR EMEILNKTTN MTQSNELLTD
260 270 280 290 300
SMDEEVAPPK PPLPCIRVAE NSPPPALPPK KRQSAPSPTR VAVVAPMSRA
310 320 330 340 350
TSGSSLPVGI NRQDFDVDCY AQRRLSGGSH SYGGESPRLS PCSSIGKLSK
360 370 380 390 400
SDEQLSSLDR DSGQCSRNTS CETLDHYDPD YEFLQQDLSN ADQIPQQVPT
410 420 430 440 450
TLSPLPESLG ESGSPFHGHA FQLPQGSSSP LEFCSLSGAV QPTETPPALP
460 470 480 490 500
EKKRRSAASQ TSDSSCRVSY ERHPSQYDNI SEDDMQNAGS LSSVPCTPFA
510 520 530 540 550
PILPFQQGNS SAQVEFIADF AAPDSNSDPE KPPPLPEKKN KHMMAYMQFV
560 570 580 590 600
EDYSEPQPSM FYQTPQNEHI YQQKNKHLME VYGFNDSFIS LDPSQDLAPP
610 620 630 640 650
PALPPKQRQL ESPSVKDGHS KDSTSNSSGG DDTDGCLPQS PDALESSQLE
660 670 680 690 700
EEVDELSLID HSEIMARLTL KQEGDDGPDV RGGSGDILLV HATETDRKDL
710 720 730 740 750
VLYCEAFLTT YRTFITPEEL IKKLHKNTFF VLVRVVDELC LVELTEEILK
760 770 780 790 800
LLMDLVFRLV CNGELSLARV LRKNILDKVD QKKMLRYANS IKPLAARGVA
810 820 830 840 850
ARPGTLHDFH SHEIAEQLTL LDAELFYKIE IPEVLLWAKE QNEEKSPNLT
860 870 880 890 900
QFTEHFNNMS YWVRSIIMLQ EKAQDRERLL LKFIKIMKHL RKLNNFNSYL
910 920 930 940 950
AILSALDSAP IRRLEWQKQT SEGLAEYCTL IDSSSSFRAY RAALADVEPP
960 970 980 990 1000
CIPYLGLILQ DLTFVHLGNP DYIDSKVNFS KRWQQFNILD SMRCFQQVHY
1010 1020 1030 1040
DIKRNDDIVS FFNDFSDHLA EEALWELSLK IKPRNITRRK TDREEKT
Length:1,047
Mass (Da):117,468
Last modified:November 30, 2016 - v3
Checksum:i8BEFFAFE54B15D9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000036 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000005891; ENSGALP00000005881; ENSGALG00000003712

Similar proteinsi

Entry informationi

Entry nameiE1BS61_CHICK
AccessioniPrimary (citable) accession number: E1BS61
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 30, 2016
Last modified: July 18, 2018
This is version 63 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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