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UniProtKB - E1BRR7 (E1BRR7_CHICK)
Protein
FMN hydroxy acid dehydrogenase domain-containing protein
Gene
HAO1
Organism
Gallus gallus (Chicken)
Status
Functioni
Catalytic activityi
- This reaction proceeds in the forwardARBA annotation direction.
- EC:1.1.3.15ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
Cofactori
FMNUniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 26 | SubstrateUniRule annotation | 1 | |
Binding sitei | 108 | FMNUniRule annotation | 1 | |
Binding sitei | 130 | FMNUniRule annotation | 1 | |
Binding sitei | 132 | SubstrateUniRule annotation | 1 | |
Binding sitei | 158 | FMNUniRule annotation | 1 | |
Binding sitei | 167 | SubstrateUniRule annotation | 1 | |
Binding sitei | 235 | FMNUniRule annotation | 1 | |
Binding sitei | 257 | FMNUniRule annotation | 1 | |
Active sitei | 259 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 262 | SubstrateUniRule annotation | 1 | |
Binding sitei | 314 | FMNUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 290 – 294 | FMNUniRule annotation | 5 |
GO - Molecular functioni
- (S)-2-hydroxy-acid oxidase activity Source: Ensembl
- FMN binding Source: Ensembl
- glyoxylate oxidase activity Source: Ensembl
GO - Biological processi
- fatty acid alpha-oxidation Source: GO_Central
- glycolate catabolic process Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | Flavoprotein, FMNUniRule annotation |
Enzyme and pathway databases
Reactomei | R-GGA-389661, Glyoxylate metabolism and glycine degradation R-GGA-9033241, Peroxisomal protein import |
Names & Taxonomyi
Protein namesi | Recommended name: FMN hydroxy acid dehydrogenase domain-containing proteinInterPro annotation |
Gene namesi | Name:HAO1Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Expressioni
Gene expression databases
Bgeei | ENSGALG00000008845, Expressed in kidney and 3 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 364 | FMN hydroxy acid dehydrogenaseInterPro annotationAdd BLAST | 364 |
Sequence similaritiesi
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG0538, Eukaryota |
GeneTreei | ENSGT00390000018717 |
HOGENOMi | CLU_020639_6_1_1 |
InParanoidi | E1BRR7 |
OMAi | FTRLMQT |
OrthoDBi | 879633at2759 |
TreeFami | TF313363 |
Family and domain databases
CDDi | cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012133, Alpha-hydoxy_acid_DH_FMN IPR000262, FMN-dep_DH IPR037396, FMN_HAD IPR008259, FMN_hydac_DH_AS |
Pfami | View protein in Pfam PF01070, FMN_dh, 1 hit |
PIRSFi | PIRSF000138, Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
E1BRR7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGKPVCVAD FEHYAKTFLP KSVYDYYRSG ADDQETLADN VAAFSRWKLY
60 70 80 90 100
PRVLRDVSVM DLSTSVLGQK ISMPVCVAAT AMQRMAHPDG ETATAKACHA
110 120 130 140 150
MGTGMMLSSW ATSSIEEVAE AAPGGLRWLQ LYVYKDREVT KSLVKRAERA
160 170 180 190 200
GYKGIFVTVD TPFLGRRIDD VRNKFQLPPH LRLKNFSSNN LDFSGRDFGE
210 220 230 240 250
DSGLAVYVAN AIDASVNWED IKWLRGLTSL PIVAKGILRA DDAKEAVKLG
260 270 280 290 300
VDGILVSNHG ARQLDGVPAT IDILPEIVEA VEGKVEVFLD GGIRKGTDIL
310 320 330 340 350
KALALGAKAV FIGRPLIWGL VYQGEEGAKE VLQMLKEEFR LAMALTGCRT
360
VKEIGRTLIR RHEVLLSKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000005 Genomic DNA No translation available. |
RefSeqi | NP_001186371.2, NM_001199442.2 |
Genome annotation databases
Ensembli | ENSGALT00000014374; ENSGALP00000014358; ENSGALG00000008845 |
GeneIDi | 416728 |
KEGGi | gga:416728 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000005 Genomic DNA No translation available. |
RefSeqi | NP_001186371.2, NM_001199442.2 |
3D structure databases
SMRi | E1BRR7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000014358 |
Proteomic databases
PaxDbi | E1BRR7 |
Genome annotation databases
Ensembli | ENSGALT00000014374; ENSGALP00000014358; ENSGALG00000008845 |
GeneIDi | 416728 |
KEGGi | gga:416728 |
Organism-specific databases
CTDi | 54363 |
Phylogenomic databases
eggNOGi | KOG0538, Eukaryota |
GeneTreei | ENSGT00390000018717 |
HOGENOMi | CLU_020639_6_1_1 |
InParanoidi | E1BRR7 |
OMAi | FTRLMQT |
OrthoDBi | 879633at2759 |
TreeFami | TF313363 |
Enzyme and pathway databases
Reactomei | R-GGA-389661, Glyoxylate metabolism and glycine degradation R-GGA-9033241, Peroxisomal protein import |
Gene expression databases
Bgeei | ENSGALG00000008845, Expressed in kidney and 3 other tissues |
Family and domain databases
CDDi | cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012133, Alpha-hydoxy_acid_DH_FMN IPR000262, FMN-dep_DH IPR037396, FMN_HAD IPR008259, FMN_hydac_DH_AS |
Pfami | View protein in Pfam PF01070, FMN_dh, 1 hit |
PIRSFi | PIRSF000138, Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E1BRR7_CHICK | |
Accessioni | E1BRR7Primary (citable) accession number: E1BRR7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 2, 2010 |
Last sequence update: | November 30, 2016 | |
Last modified: | May 25, 2022 | |
This is version 68 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |