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Protein

Non-specific serine/threonine protein kinase

Gene

MARK3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central
  • tau-protein kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-5673000 RAF activation
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-5675221 Negative regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:MARK3Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000011505 Expressed in 10 organ(s), highest expression level in spleen

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 307Protein kinaseInterPro annotationAdd BLAST252
Domaini326 – 365UBAInterPro annotationAdd BLAST40
Domaini744 – 793KA1InterPro annotationAdd BLAST50

Phylogenomic databases

GeneTreeiENSGT00900000140806
InParanoidiE1BRA3
OrthoDBiEOG091G0D1E
TreeFamiTF315213

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR033624 MARK/par1
IPR033628 MARK3
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
PANTHERiPTHR24346 PTHR24346, 1 hit
PTHR24346:SF1 PTHR24346:SF1, 1 hit
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

E1BRA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTRTPLPTV NERDTENHTS HGDGRQEVSS RTGRSGARCR NSIASCADEQ
60 70 80 90 100
PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL
110 120 130 140 150
FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM
160 170 180 190 200
KEKEARAKFR QIVSAVQYCH QKHIVHRDLK AENLLLDADM NIKIADFGFS
210 220 230 240 250
NEFTVGNKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS
260 270 280 290 300
LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPTKRGTLEQ
310 320 330 340 350
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS
360 370 380 390 400
KMKYDEITAT YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS
410 420 430 440 450
PHHKVQRSIS SSQKQRRYSD HAGPSIPPVV AYPKRSQTST TDSDLKEEGI
460 470 480 490 500
QSRKSSSSAV AGRGIAPASP MLGNASNPNK ADIPERKKSS AVPSNNTAPG
510 520 530 540 550
AMTRRNTYVC SERTTADRHS VIQNGKENSL TEMFAYAASP ASVCTTSFSS
560 570 580 590 600
VRLRHQKSMS MSASVHTKMM LPPIDNGADN FRPITIPDQR TPVASTHSIS
610 620 630 640 650
SATTPDRIRF PRGTASRSTF HGQLRERRTA TYNGPPASPS LSHEATPLSQ
660 670 680 690 700
TRTRGSTNLF SKLTSKLTRR NMSFRFIKSR NVAVDQKDEN KEAKPRSLRF
710 720 730 740 750
TWSMKTTSSM DPNDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL
760 770 780 790
VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL
Length:793
Mass (Da):88,921
Last modified:November 30, 2016 - v3
Checksum:i5856BA413C642F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000016 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000018759; ENSGALP00000018736; ENSGALG00000011505

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000016 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018759; ENSGALP00000018736; ENSGALG00000011505

Phylogenomic databases

GeneTreeiENSGT00900000140806
InParanoidiE1BRA3
OrthoDBiEOG091G0D1E
TreeFamiTF315213

Enzyme and pathway databases

ReactomeiR-GGA-5673000 RAF activation
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-5675221 Negative regulation of MAPK pathway

Gene expression databases

BgeeiENSGALG00000011505 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR033624 MARK/par1
IPR033628 MARK3
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
PANTHERiPTHR24346 PTHR24346, 1 hit
PTHR24346:SF1 PTHR24346:SF1, 1 hit
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE1BRA3_CHICK
AccessioniPrimary (citable) accession number: E1BRA3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 66 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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