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Protein

Core histone macro-H2A

Gene

H2AFY2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Core histone macro-H2AUniRule annotation
Gene namesi
Name:H2AFY2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Chromosome, Membrane, Nucleosome coreUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateUniRule annotation
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)UniRule annotation

Proteomic databases

PaxDbiE1BR08

Expressioni

Gene expression databases

BgeeiENSGALG00000004794 Expressed in 11 organ(s), highest expression level in testis
ExpressionAtlasiE1BR08 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007639

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 367MacroInterPro annotationAdd BLAST187

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
InParanoidiE1BR08
OrthoDBiEOG091G0XGD
PhylomeDBiE1BR08
TreeFamiTF332276

Family and domain databases

CDDicd00074 H2A, 1 hit
cd02904 Macro_H2A_like, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR021171 Core_histone_macro-H2A
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR002589 Macro_dom
IPR035796 Macro_H2A
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PF01661 Macro, 1 hit
PIRSFiPIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E1BR08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRSGKKKM SKLSRSSRAG VIFPVGRMMR YLKKGTYKYR IGVGAPVYMA
60 70 80 90 100
AVIEYLAAEI LELAGNAARD NKKGRIAPRH ILLAVANDEE LNQLLKGVTI
110 120 130 140 150
ASGGVLPRIQ PELLAKKRGA KGKSETILSP APEKKGRKSM VSKKSGKKAK
160 170 180 190 200
SNKARTPKKK DSEKEGASNS TSEDGPGDGF TILSSKSLVP GQKLSLTQSD
210 220 230 240 250
ISHIGSMKVE GIVHPTTAEI DLKEEIGKAL EKAGGKEFLE TVKELRKSQG
260 270 280 290 300
PLEVAEAALT QSSGLAAKFV IHCHIPQWGS DKCEEQLEET IKNCLTAAED
310 320 330 340 350
KKLKSVAFPP FPSGRNCFPK QTAAQVTLRA ISTHFDGTSS SSLKNIYFLL
360
FDSESIGIYV QEMAKLDTK
Length:369
Mass (Da):39,874
Last modified:November 30, 2016 - v2
Checksum:i17A43620D4BF6427
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1RSN9A0A1L1RSN9_CHICK
Core histone macro-H2A
H2AFY2
372Annotation score:
A0A1L1RX25A0A1L1RX25_CHICK
Uncharacterized protein
H2AFY2
163Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04023949 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSGALT00000007651; ENSGALP00000007639; ENSGALG00000004794

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04023949 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007639

Proteomic databases

PaxDbiE1BR08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000007651; ENSGALP00000007639; ENSGALG00000004794

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
InParanoidiE1BR08
OrthoDBiEOG091G0XGD
PhylomeDBiE1BR08
TreeFamiTF332276

Gene expression databases

BgeeiENSGALG00000004794 Expressed in 11 organ(s), highest expression level in testis
ExpressionAtlasiE1BR08 baseline and differential

Family and domain databases

CDDicd00074 H2A, 1 hit
cd02904 Macro_H2A_like, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR021171 Core_histone_macro-H2A
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR002589 Macro_dom
IPR035796 Macro_H2A
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PF01661 Macro, 1 hit
PIRSFiPIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE1BR08_CHICK
AccessioniPrimary (citable) accession number: E1BR08
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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