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UniProtKB - E1BQ43 (E1BQ43_CHICK)

Entry version 94 (07 Oct 2020)
Sequence version 1 (02 Nov 2010)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

TTL

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei74ADPCombined sources1
Binding sitei74ATP analogCombined sources1
Binding sitei150ADPCombined sources1
Binding sitei150ATP analogCombined sources1
Binding sitei156ATP analog; via carbonyl oxygenCombined sources1
Binding sitei200ADPCombined sources1
Binding sitei222ATP analogCombined sources1
Binding sitei331ADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi183 – 186ADPCombined sources4
Nucleotide bindingi183 – 186ATP analogCombined sources4
Nucleotide bindingi198 – 202ATP analogCombined sources5
Nucleotide bindingi239 – 242ADPCombined sources4
Nucleotide bindingi239 – 242ATP analogCombined sources4
Nucleotide bindingi318 – 320ATP analogCombined sources3
Nucleotide bindingi331 – 333ATP analogCombined sources3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandNucleotide-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E1BQ43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSGALG00000008614, Expressed in skeletal muscle tissue and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-61410N

Protein interaction database and analysis system

More...IntActi		E1BQ43, 3 interactors

STRING: functional protein association networks

More...STRINGi		9031.ENSGALP00000014019

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E1BQ43

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2157, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161907

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010131_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E1BQ43

KEGG Orthology (KO)

More...KOi		K06047

Identification of Orthologs from Complete Genome Data

More...OMAi		DDNSTVY

Database of Orthologous Groups

More...OrthoDBi		626048at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E1BQ43

TreeFam database of animal gene trees

More...TreeFami		TF350555

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004344, TTL/TTLL_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03133, TTL, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51221, TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1BQ43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYTFVVRDEN SSVYAEVSRL LLATGQWKRL RKDNPRFNLM LGERNRLPFG 
        60         70         80         90        100
RLGHEPGLVQ LVNYYRGADK LCRKASLVKL IKTSPELSES CTWFPESYVI 
       110        120        130        140        150
YPTNLKTPVA PAQNGIRHLI NNTRTDEREV FLAAYNRRRE GREGNVWIAK 
       160        170        180        190        200
SSAGAKGEGI LISSEASELL DFIDEQGQVH VIQKYLEKPL LLEPGHRKFD 
       210        220        230        240        250
IRSWVLVDHL YNIYLYREGV LRTSSEPYNS ANFQDKTCHL TNHCIQKEYS 
       260        270        280        290        300
KNYGRYEEGN EMFFEEFNQY LMDALNTTLE NSILLQIKHI IRSCLMCIEP 
       310        320        330        340        350
AISTKHLHYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI 
       360        370 
VDVAISSVFP LADTGQKTSQ PTSIFIKL
Length:378
Mass (Da):43,496
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F4734154DF09BBD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AADN05000005 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001186321.1, NM_001199392.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSGALT00000014035; ENSGALP00000014019; ENSGALG00000008614

Database of genes from NCBI RefSeq genomes

More...GeneIDi		416711

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		gga:416711

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000005 Genomic DNA No translation available.
RefSeqiNP_001186321.1, NM_001199392.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I4TX-ray1.80F1-378[»]
4I50X-ray2.30F1-378[»]
4I55X-ray2.20F1-378[»]
4IHJX-ray2.00F1-378[»]
4IIJX-ray2.60F1-378[»]
4O2AX-ray2.50F1-378[»]
4O2BX-ray2.30F1-378[»]
4O4HX-ray2.10F1-378[»]
4O4IX-ray2.40F1-378[»]
4O4JX-ray2.20F1-378[»]
4O4LX-ray2.20F1-378[»]
4TUYX-ray2.10F1-378[»]
4TV8X-ray2.10F1-378[»]
4TV9X-ray2.00F1-378[»]
4YJ2X-ray2.60F1-378[»]
4YJ3X-ray3.75F1-378[»]
4ZHQX-ray2.55F1-378[»]
4ZI7X-ray2.51F1-378[»]
4ZOLX-ray2.50F1-378[»]
5BMVX-ray2.50F1-378[»]
5C8YX-ray2.59F1-378[»]
5CA0X-ray2.50F1-378[»]
5CA1X-ray2.40F1-378[»]
5CB4X-ray2.19F1-378[»]
5EZYX-ray2.05F1-378[»]
5FNVX-ray2.61F1-378[»]
5GONX-ray2.48F1-378[»]
5H74X-ray2.60F1-378[»]
5H7OX-ray2.80F1-378[»]
5IYZX-ray1.80F1-378[»]
5J2TX-ray2.20F1-378[»]
5JCBX-ray2.30F1-378[»]
5JH7X-ray2.25F1-378[»]
5JQGX-ray2.24F1-378[»]
5JVDX-ray2.39F1-378[»]
5KX5X-ray2.50F1-378[»]
5LA6X-ray2.10F1-378[»]
5LOVX-ray2.40F1-378[»]
5LP6X-ray2.90F1-378[»]
5LXSX-ray2.20F1-378[»]
5LXTX-ray1.90F1-378[»]
5LYJX-ray2.40F1-378[»]
5M7EX-ray2.05F1-378[»]
5M7GX-ray2.25F1-378[»]
5M8DX-ray2.25F1-378[»]
5M8GX-ray2.15F1-378[»]
5MF4X-ray2.30F1-378[»]
5NFZX-ray2.10F1-378[»]
5NG1X-ray2.20F1-378[»]
5NJHX-ray2.39F1-378[»]
5O7AX-ray2.50F1-378[»]
5OSKX-ray2.11F1-378[»]
5OV7X-ray2.40F1-378[»]
5XAFX-ray2.55F1-378[»]
5XAGX-ray2.56F1-378[»]
5XHCX-ray2.75F1-378[»]
5XI5X-ray2.81F1-378[»]
5XI7X-ray2.99F1-378[»]
5XIWX-ray2.90F1-378[»]
5XKEX-ray2.60F1-378[»]
5XKFX-ray2.80F1-378[»]
5XKGX-ray2.20F1-378[»]
5XKHX-ray2.25F1-378[»]
5XLTX-ray2.81F1-378[»]
5XLZX-ray2.30F1-378[»]
5XP3X-ray2.30F1-378[»]
5YL2X-ray2.09F1-378[»]
5YL4X-ray2.64F1-378[»]
5YLJX-ray2.70F1-378[»]
5YLSX-ray3.00F1-378[»]
5YZ3X-ray2.54F1-378[»]
5Z4PX-ray2.50F1-378[»]
5Z4UX-ray3.18F1-378[»]
5ZXHX-ray2.80F1-378[»]
6AGKX-ray2.80F1-378[»]
6BR1X-ray2.30F1-378[»]
6BRFX-ray2.50F1-378[»]
6BRYX-ray2.70F1-378[»]
6BS2X-ray2.65F1-378[»]
6D88X-ray2.85F1-378[»]
6EG5X-ray2.45F1-378[»]
6F7CX-ray2.00F1-378[»]
6FIIX-ray2.40F1-378[»]
6FJFX-ray2.40F1-378[»]
6FJMX-ray2.10F1-378[»]
6FKJX-ray2.15F1-378[»]
6FKLX-ray2.10F1-378[»]
6GF3X-ray2.40F1-378[»]
6GJ4X-ray2.40F1-378[»]
6GZEX-ray2.49F1-378[»]
6HX8X-ray2.40F1-378[»]
6I5CX-ray2.95F1-378[»]
6JCJX-ray2.50F1-378[»]
6K9VX-ray2.54F1-378[»]
6KNZX-ray2.48F1-378[»]
6N47X-ray2.60F1-378[»]
6NNGX-ray2.40F1-378[»]
6O5MX-ray2.30F1-378[»]
6O5NX-ray3.00F1-378[»]
6O61X-ray2.60F1-378[»]
6PC4X-ray2.60F1-378[»]
6QQNX-ray2.30F1-378[»]
6QTNX-ray1.90F1-378[»]
6S9EX-ray2.25F1-378[»]
SMRiE1BQ43
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61410N
IntActiE1BQ43, 3 interactors
STRINGi9031.ENSGALP00000014019

Proteomic databases

PaxDbiE1BQ43

Genome annotation databases

EnsembliENSGALT00000014035; ENSGALP00000014019; ENSGALG00000008614
GeneIDi416711
KEGGigga:416711

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		150465

Phylogenomic databases

eggNOGiKOG2157, Eukaryota
GeneTreeiENSGT00940000161907
HOGENOMiCLU_010131_2_0_1
InParanoidiE1BQ43
KOiK06047
OMAiDDNSTVY
OrthoDBi626048at2759
PhylomeDBiE1BQ43
TreeFamiTF350555

Gene expression databases

BgeeiENSGALG00000008614, Expressed in skeletal muscle tissue and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR004344, TTL/TTLL_fam
PfamiView protein in Pfam
PF03133, TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221, TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BQ43_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BQ43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 7, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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