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Protein
Submitted name:

Adenylate cyclase 9

Gene

ADCY9

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • adenylate cyclase activity Source: GO_Central
  • nucleotide binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-163359 Glucagon signaling in metabolic regulation
R-BTA-163615 PKA activation
R-BTA-164378 PKA activation in glucagon signalling
R-BTA-170660 Adenylate cyclase activating pathway
R-BTA-170670 Adenylate cyclase inhibitory pathway
R-BTA-418555 G alpha (s) signalling events
R-BTA-418597 G alpha (z) signalling events
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-5610787 Hedgehog 'off' state

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 9Imported
Submitted name:
Adenylyl CYclase family member (Acy-1)-likeImported
Gene namesi
Name:ADCY9Imported
ORF Names:BOS_22626Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:25650 ADCY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Transmembranei242 – 261HelicalSequence analysisAdd BLAST20
Transmembranei788 – 809HelicalSequence analysisAdd BLAST22
Transmembranei821 – 845HelicalSequence analysisAdd BLAST25
Transmembranei922 – 940HelicalSequence analysisAdd BLAST19
Transmembranei978 – 997HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSBTAG00000016629 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022120

Structurei

3D structure databases

SMRiE1BM79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 521Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini1059 – 1199Guanylate cyclaseInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
KOiK08049
OMAiFETNIHF
OrthoDBiEOG091G0285
TreeFamiTF313845

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

E1BM79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPHQQLL QHHSTEVSCD SSGDSNSVRV RINPKQPSSN SHPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGVPRRMGAG GRLRRRKKLP QLFERASSRW WDPKFDSVNL
110 120 130 140 150
EEACMERCFP QTQRRFRYAL FYIGFACLLW SIYFGVHMKS KLIVMVAPAL
160 170 180 190 200
CFLVVCVGFF LFTFTKLYAR HYVWTSLVLT LLVFALTLAA QFQVLTPLSG
210 220 230 240 250
RVDNFNHTRA ARPTDTCLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLILGV
260 270 280 290 300
AYSVLFETFG YHFQDEACFA SPGAEALHWE LLSRALLHLC IHAIGIHLFI
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI RAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV
560 570 580 590 600
TERLGQSVVA DQLKGLKTYL IAGQRAKESH CSCSEALLSG FEVLDGSRVS
610 620 630 640 650
SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFTPK PEAGAEGGAV
660 670 680 690 700
QNGCQEEPKN SAKASGGPSS KTQNGLLSPP PEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF
760 770 780 790 800
SLNFLDPELE RAYRTSYQEE VVKSSPVRTF ASATFSSLLD VLLSTTVFLI
810 820 830 840 850
LSITCFLRYG AASTPPPPAA LAVFGAALLL EILSLVVSVR MVFFLEDVMT
860 870 880 890 900
CTKRLLEWIA GWLPRHFIGA ILVSLPALAV YSHVTSEFET NIHSTMFTGS
910 920 930 940 950
AVLTAVVQYC NFCQLSSWMR SSLATVVGAG PLLLLLYVSL CPDSSTVISH
960 970 980 990 1000
LDAVQNFSST RKLCNASLPH DGRSPASLIG QEVILVFFLL LLLVWFLNRE
1010 1020 1030 1040 1050
FEVSYRLHYH GDVEADLHRT KIQSMRDQAD WLLRNIIPYH VAEQLKVSQT
1060 1070 1080 1090 1100
YSKNHDSGGV IFASIVNFSE FYEENYEGGK ECYRVLNELI GDFDELLSKP
1110 1120 1130 1140 1150
DYSSIEKIKT IGATYMAASG LNATQCRDGS HPQEHLQILF EFAKEMMRVV
1160 1170 1180 1190 1200
DDFNNNMLWF NFKLRVGFNH GPLTAGVIGT TKLLYDIWGD TVNIASRMDT
1210 1220 1230 1240 1250
TGVECRIQVS EESYRVLSKM GYEFDYRGTV NVKGKGQMKT YLYPKCTDSG
1260 1270 1280 1290 1300
LVPQHQLSIS PDIRVQVDGS IGRSPTDEIA SLVPSVQNPD QVPPGSENNA
1310 1320 1330 1340 1350
QTRDAHPSAK RPWKEPVRAE ERCRFGKAIE KSDCEEVGME EANELTKLNV

SERA
Length:1,354
Mass (Da):150,963
Last modified:November 16, 2011 - v2
Checksum:i331E053F0F3FC79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057330 Genomic DNA No translation available.
GJ062847 Genomic DNA Translation: DAA15720.1
RefSeqiNP_001192846.1, NM_001205917.1
XP_005224539.1, XM_005224482.3
UniGeneiBt.81524

Genome annotation databases

EnsembliENSBTAT00000022120; ENSBTAP00000022120; ENSBTAG00000016629
GeneIDi525482
KEGGibta:525482

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057330 Genomic DNA No translation available.
GJ062847 Genomic DNA Translation: DAA15720.1
RefSeqiNP_001192846.1, NM_001205917.1
XP_005224539.1, XM_005224482.3
UniGeneiBt.81524

3D structure databases

SMRiE1BM79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022120

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022120; ENSBTAP00000022120; ENSBTAG00000016629
GeneIDi525482
KEGGibta:525482

Organism-specific databases

CTDi115
VGNCiVGNC:25650 ADCY9

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
KOiK08049
OMAiFETNIHF
OrthoDBiEOG091G0285
TreeFamiTF313845

Enzyme and pathway databases

ReactomeiR-BTA-163359 Glucagon signaling in metabolic regulation
R-BTA-163615 PKA activation
R-BTA-164378 PKA activation in glucagon signalling
R-BTA-170660 Adenylate cyclase activating pathway
R-BTA-170670 Adenylate cyclase inhibitory pathway
R-BTA-418555 G alpha (s) signalling events
R-BTA-418597 G alpha (z) signalling events
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-5610787 Hedgehog 'off' state

Gene expression databases

BgeeiENSBTAG00000016629 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE1BM79_BOVIN
AccessioniPrimary (citable) accession number: E1BM79
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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