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Protein
Submitted name:

TANK binding kinase 1

Gene

TBK1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-3249367 STAT6-mediated induction of chemokines
R-BTA-3270619 IRF3-mediated induction of type I IFN
R-BTA-9008059 Interleukin-37 signaling
R-BTA-936440 Negative regulators of DDX58/IFIH1 signaling
R-BTA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Names & Taxonomyi

Protein namesi
Submitted name:
TANK binding kinase 1Imported
Gene namesi
Name:TBK1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:35656 TBK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE1BKP4

Expressioni

Gene expression databases

BgeeiENSBTAG00000017401

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023134

Structurei

3D structure databases

ProteinModelPortaliE1BKP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 310Protein kinaseInterPro annotationAdd BLAST302

Phylogenomic databases

eggNOGiKOG4250 Eukaryota
ENOG410XRMU LUCA
GeneTreeiENSGT00910000144033
InParanoidiE1BKP4
KOiK05410
OMAiFRGRHKK
OrthoDBiEOG091G0354
TreeFamiTF324269

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

E1BKP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD
60 70 80 90 100
VQMREFEVLK KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE
110 120 130 140 150
PSNAYGLPES EFLIVLRDVV GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ
160 170 180 190 200
SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKDHQKKYGA
210 220 230 240 250
TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG KPSGAISGVQ
260 270 280 290 300
KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA
310 320 330 340 350
ETSDILHRMI VHVFSLQQMT AHKVYIHGYN TATVFHELVY KQTKIISSNQ
360 370 380 390 400
ELIYEGRRLV LEPGRLAQHF PKTSEENPIF VVSREPLSTI GLIYEKISLP
410 420 430 440 450
KVHPRYDLDG DASMAKAMTG VVCYACRIAS TLLLYQELVR KGIRWLIELV
460 470 480 490 500
KDDYNETVHK KTEVVITLDF CIRNIEKTVK VYEKLMKINL EAAELGEISD
510 520 530 540 550
IHTKLLRLSS SQGTIETSLQ DIESKLSPGG LLADTWTHQE GTHPKDRHVE
560 570 580 590 600
KLQVLLNCIT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH
610 620 630 640 650
FTDECVKKYE AFLDKSEEWM RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY
660 670 680 690 700
TNELQETLPQ KMFAASSGIK HTMTPIYPCS NTLVEMTLGM KKLKEEMEGV
710 720
VKELAENNHI LERFGSLTMD GGLRNVDCL
Length:729
Mass (Da):83,597
Last modified:November 16, 2011 - v2
Checksum:i4983805C046481F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02013341 Genomic DNA No translation available.
RefSeqiNP_001179684.1, NM_001192755.1
XP_005206693.1, XM_005206636.3
UniGeneiBt.63014

Genome annotation databases

EnsembliENSBTAT00000023134; ENSBTAP00000023134; ENSBTAG00000017401
GeneIDi533141
KEGGibta:533141

Similar proteinsi

Entry informationi

Entry nameiE1BKP4_BOVIN
AccessioniPrimary (citable) accession number: E1BKP4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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