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Protein
Submitted name:

Serine protease 12

Gene

PRSS12

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Serine protease 12Imported
Gene namesi
Name:PRSS12Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:33413 PRSS12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500567267321 – 871Sequence analysisAdd BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 255PROSITE-ProRule annotation
Disulfide bondi204 ↔ 265PROSITE-ProRule annotation
Disulfide bondi235 ↔ 245PROSITE-ProRule annotation
Disulfide bondi301 ↔ 365PROSITE-ProRule annotation
Disulfide bondi314 ↔ 375PROSITE-ProRule annotation
Disulfide bondi345 ↔ 355PROSITE-ProRule annotation
Disulfide bondi451 ↔ 461PROSITE-ProRule annotation
Disulfide bondi521 ↔ 585PROSITE-ProRule annotation
Disulfide bondi534 ↔ 595PROSITE-ProRule annotation
Disulfide bondi565 ↔ 575PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiE1BK01

Expressioni

Gene expression databases

BgeeiENSBTAG00000020705

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027594

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 164KringleInterPro annotationAdd BLAST68
Domaini166 – 266SRCRInterPro annotationAdd BLAST101
Domaini276 – 376SRCRInterPro annotationAdd BLAST101
Domaini383 – 482SRCRInterPro annotationAdd BLAST100
Domaini496 – 596SRCRInterPro annotationAdd BLAST101
Domaini627 – 870Peptidase S1InterPro annotationAdd BLAST244

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140803
InParanoidiE1BK01
OMAiCIKQDIG
OrthoDBiEOG091G0DF7
TreeFamiTF329295

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 1 hit
3.10.250.10, 4 hits
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
PF00530 SRCR, 4 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
PR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00130 KR, 1 hit
SM00202 SR, 4 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 4 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS00420 SRCR_1, 3 hits
PS50287 SRCR_2, 4 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

E1BK01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPHFAVAL ILGALPGVVS FDSVLGYPLH HRHHHAPSRS PQDPYYLTIQ
60 70 80 90 100
RRPQKTLPPP LPRTLHPAPA LRASRAHGLR TPRPPPGDCP AGAPGANVTD
110 120 130 140 150
SGAPCLRWAD VPPFLARSPP AGWAQLRGQR HNFCRSPDGA GRPWCFYGDA
160 170 180 190 200
RGKVDWGYCD CRRGSVQLRG GKSAFEGTVE VYENGVWGVV CSSHWDDADA
210 220 230 240 250
SVVCHQLQLG GKGVAKQTPF SELGLIPVYW SNVRCRGDEE NILLCEKDIW
260 270 280 290 300
QGGACSEKMA AAVLCSFSHG PAFPILRLVG GSSVREGRVE VYHAGQWGTV
310 320 330 340 350
CDDQWDDADA EVVCRQLGLS GIAKAWNQAY FGEGSGPVML DEVRCTGNEL
360 370 380 390 400
SIEQCPKSSW GEHNCDHKED AGVSCTPLTD GVIRLAGGKG SHEGRLEVYH
410 420 430 440 450
RGQWGTVCND GWTDLNTYVV CRQLGFKYGK QASANHFEES MGPIWLDGVS
460 470 480 490 500
CSGKEASFLQ CSQRPWGSHD CSHREDVGIS CYPGGNGFRL SLGFPIRLMD
510 520 530 540 550
GENKKEGRVE VFINGQWGTV CDDGWTDKDA TVICRQLGYK GPARARSMAY
560 570 580 590 600
FGEGEGPIHM DNVKCTGNER SLADCVRQNI GDHNCRHSED AGVICDYLGK
610 620 630 640 650
KASGNNSKES LSSVCGLRLL PRRQKRIIGG KNSLRGSWPW QVSLRLKSSH
660 670 680 690 700
GDGRLLCGAT LLSSCWVLTA AHCFKRYGNS TRNYVVRVGD YHTLVPEEFE
710 720 730 740 750
EEIRVEQIVT HRLYRPHSND YDIALVRLQG PEEQCARLSS HVLPACLPRW
760 770 780 790 800
RERPQKRAHN CYVTGWGDTG PAYSRTLQQG AIPLLPKRFC EHRYKGRFTR
810 820 830 840 850
RMLCAGNLHE HKRVDSCQGD SGGPLVCERL GERWVVYGVT SWGYGCGVKD
860 870
SPGVYTEVSA FVPWIKRVTK L
Length:871
Mass (Da):96,135
Last modified:November 16, 2011 - v2
Checksum:iCA1F4F88A0ED2D7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02016331 Genomic DNA No translation available.
DAAA02016332 Genomic DNA No translation available.
DAAA02016333 Genomic DNA No translation available.
DAAA02016334 Genomic DNA No translation available.
DAAA02016335 Genomic DNA No translation available.
RefSeqiXP_010804183.2, XM_010805881.2

Genome annotation databases

EnsembliENSBTAT00000027594; ENSBTAP00000027594; ENSBTAG00000020705
GeneIDi512034

Similar proteinsi

Entry informationi

Entry nameiE1BK01_BOVIN
AccessioniPrimary (citable) accession number: E1BK01
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: July 18, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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