Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Synemin

Gene

SYNM

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SyneminImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:35529 SYNM

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BIS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000011752 Expressed in 9 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000015606

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1BIS6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 322IF rodInterPro annotationAdd BLAST312

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 49Sequence analysisAdd BLAST35
Coiled coili78 – 105Sequence analysisAdd BLAST28
Coiled coili113 – 150Sequence analysisAdd BLAST38
Coiled coili192 – 279Sequence analysisAdd BLAST88
Coiled coili533 – 559Sequence analysisAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH92 Eukaryota
ENOG4111GBF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159268

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BIS6

KEGG Orthology (KO)

More...
KOi
K10376

Identification of Orthologs from Complete Genome Data

More...
OMAi
RESQQMR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00OT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR030634 SYNM

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit
PTHR23239:SF194 PTHR23239:SF194, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1BIS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSWRLHTGP EKAELQELNA RLYDYVCRVR ELERENLLLE EELRSRRGQE
60 70 80 90 100
GLWAEAEARC TEEARGLRRQ LDELSWATAL AQGERDALRR ELRELQLLGE
110 120 130 140 150
ETRAARGRLD AELDSQRREL QEELAARAAL EALLGRLQAE RRGLDAARER
160 170 180 190 200
DVRELRARAA GLTLRYRGRV AGPAAPPLRL RELHEDCALL VTEAWRETVQ
210 220 230 240 250
RYEDEVRELE EALRRGRESR REAEEETRLC AQEAEALRRE VLELEQLRAL
260 270 280 290 300
LEEELLRVRE ASELQAEERQ REIAYLEDEK AALTLAMADR LRDYQDLVQV
310 320 330 340 350
KTGLSLEVAT YRALLEGESN PEILIVECIE NMPQEFREKS YQYTTSVLQK
360 370 380 390 400
ENERNLFPRQ KAPPASFRQS LAPRSQTPVR SDARRDVLGS GYSSFTTAWQ
410 420 430 440 450
ENAYQKTASG QTNFRTFSPT PGLLRNTEAQ LKTFPERPRT EGTKAPPASS
460 470 480 490 500
AKESAAAAEP YQERRAEEAA AASEGTWSNE RTVIWGKKTE AKATKEQERN
510 520 530 540 550
RPGTIQTKRE EKMFDSKEKA SEERNLRWEE LTKLDKEARK RESEQMREKA
560 570 580 590 600
REKESLKEES VKGREIPIRL EASQDSTAKV APQDLQTPLK EDAGDGTGRG
610 620 630 640 650
VETREAGFTL GASDTTASLK GGSMTETIAE NIVSSILKQF THSPEAEASA
660 670 680 690 700
ESFPDTKVTY VDRKEVPGDR KAKTEIVVES KLTEEIDISD EAGLDYLLSK
710 720 730 740 750
DAKEVELKGK SAERLIGDVI RLGLKGKEGR AKVVNVEIIE EPMSYVSSEK
760 770 780 790 800
EDEFSTPFEV EEIDDVSPSS RGLVEEREEA VYGESDVTCS GDAGQEARRP
810 820 830 840 850
QESVTHVEEV TEAGDLEGEQ SYFVSTPDEH PGAPEREEGS VYGQIHIEEE
860 870 880 890 900
STIRYSWQDE IVPGSRRRVR RDDVPGEKVV KPVDVPEVPL EGDTASAPWK
910 920 930 940 950
EQTRSGEFHA KPIVIEKEIK IPHEFHTSIK EGSKEPRHQL VEVIEQLEEN
960 970 980 990 1000
LPERMKEELS ALTREGQGGP AGVSFDVKKV QSAGSGAVTL VAEVNLSQTV
1010 1020 1030 1040 1050
DADQLDLEEL SKDEAGEIEK AVESVVRDSL ARRRSPGPGS PEAEAGGGFR
1060 1070 1080 1090 1100
RWATQELYSS SAGEADAGLA SPPGPVSATV EVTSPTGFVH AHVLEDVSQS
1110 1120 1130 1140 1150
GGRVQIASPG MWRTEQVSAE GRAAQAVEVS AEGQASWAEG SAGTSRSARL
1160 1170 1180 1190 1200
ITLGARQSPV STEVIFPGPD AACPEAGGTE EPGPAELPTE PPRFGRHSPF
1210 1220 1230 1240 1250
GSQQFYAQRE VIFQAPVSGV GKAGDSSQAE ESAGTQTSVK HLQLGTREGL
1260 1270 1280 1290 1300
TEQTQLTAPL SGAVELGVRE ASVLMEAWSG DGTSIRHVTI GPQRHQATEP
1310 1320 1330 1340 1350
IVPPPLEFSD SESSTHREGS ADETLATSSY TVGRNILVTE KSTFQRAVSE
1360 1370 1380 1390 1400
SPQEASAEDM SGNEVTSGVS RSFRHIQLGP AEAKTSEHIV FHGPISKTFA
1410 1420 1430 1440 1450
LAGSVDSPEV SEVADSGRTL RHVALGPKET SFTFQMDVSN VEATSRWTQE
1460 1470 1480 1490 1500
ARVLFPAGTE AEAPSVSEPG AWRDASSRND LAAGVSFQGS AGDRHQAPGE
1510 1520 1530 1540
RGKEQAEFDK TVQLQRMVDQ RSVISDEKKV ALLYLDSQEE ENEGHWF
Length:1,547
Mass (Da):170,786
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4963F1095B2E664A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DAAA02051763 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001178382.1, NM_001191453.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Bt.105256

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000015606; ENSBTAP00000015606; ENSBTAG00000011752

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
514186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:514186

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02051763 Genomic DNA No translation available.
RefSeqiNP_001178382.1, NM_001191453.1
UniGeneiBt.105256

3D structure databases

SMRiE1BIS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015606

Proteomic databases

PaxDbiE1BIS6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015606; ENSBTAP00000015606; ENSBTAG00000011752
GeneIDi514186
KEGGibta:514186

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23336
VGNCiVGNC:35529 SYNM

Phylogenomic databases

eggNOGiENOG410IH92 Eukaryota
ENOG4111GBF LUCA
GeneTreeiENSGT00940000159268
InParanoidiE1BIS6
KOiK10376
OMAiRESQQMR
OrthoDBiEOG091G00OT

Gene expression databases

BgeeiENSBTAG00000011752 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR030634 SYNM
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF194 PTHR23239:SF194, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BIS6_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BIS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: December 5, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again