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Protein

Tyrosine-protein kinase

Gene

SRC

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-1227986 Signaling by ERBB2
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-1295596 Spry regulation of FGF signaling
R-BTA-1433557 Signaling by SCF-KIT
R-BTA-1433559 Regulation of KIT signaling
R-BTA-180292 GAB1 signalosome
R-BTA-186763 Downstream signal transduction
R-BTA-191647 c-src mediated regulation of Cx43 function and closure of gap junctions
R-BTA-2029481 FCGR activation
R-BTA-354192 Integrin alphaIIb beta3 signaling
R-BTA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-BTA-372708 p130Cas linkage to MAPK signaling for integrins
R-BTA-389356 CD28 co-stimulation
R-BTA-389513 CTLA4 inhibitory signaling
R-BTA-3928662 EPHB-mediated forward signaling
R-BTA-3928663 EPHA-mediated growth cone collapse
R-BTA-3928664 Ephrin signaling
R-BTA-3928665 EPH-ephrin mediated repulsion of cells
R-BTA-418592 ADP signalling through P2Y purinoceptor 1
R-BTA-418885 DCC mediated attractive signaling
R-BTA-430116 GP1b-IX-V activation signalling
R-BTA-437239 Recycling pathway of L1
R-BTA-4420097 VEGFA-VEGFR2 Pathway
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-5218921 VEGFR2 mediated cell proliferation
R-BTA-5607764 CLEC7A (Dectin-1) signaling
R-BTA-5673000 RAF activation
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-69231 Cyclin D associated events in G1
R-BTA-8853659 RET signaling
R-BTA-8874081 MET activates PTK2 signaling
R-BTA-8934903 Receptor Mediated Mitophagy
R-BTA-8941858 Regulation of RUNX3 expression and activity
R-BTA-9603381 Activated NTRK3 signals through PI3K

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:SRCImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:35269 SRC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE1BIM8

PTM databases

iPTMnetiE1BIM8

Expressioni

Gene expression databases

BgeeiENSBTAG00000008938 Expressed in 10 organ(s), highest expression level in colon

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011767

Structurei

3D structure databases

ProteinModelPortaliE1BIM8
SMRiE1BIM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 151SH3InterPro annotationAdd BLAST62
Domaini157 – 254SH2InterPro annotationAdd BLAST98
Domaini276 – 529Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
InParanoidiE1BIM8
KOiK05704
OMAiCQCWRKD
OrthoDBiEOG091G0D46
TreeFamiTF351634

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

E1BIM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSNKSKPKD ASQRRRSLES AENTHGGGGG GGGGGGAFPS SQTPSKPASS
60 70 80 90 100
DGHRGPNTAF APAAAEPKLF GGFNSSDTVT SPQRAGPLSG GVTTFVALYD
110 120 130 140 150
YESRTETDLS FKKGERLQIV NNTEGDWWLA HSLSTGQTGY IPSNYVAPSD
160 170 180 190 200
SIQAEEWYFG KITRRESERL LLNAENPRGT FLVRESETTK GAYCLSVSDF
210 220 230 240 250
DNAKGLNVKH YKIRKLDSGG FYITSRTQFN SLQQLVAYYS KHADGLCHRL
260 270 280 290 300
TTVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR
310 320 330 340 350
VAIKTLKPGT MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM
360 370 380 390 400
SKGSLLDFLK GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN
410 420 430 440 450
ILVGESLVCK VADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI
460 470 480 490 500
KSDVWSFGIL LTELTTKGRV PYPGMVNREV LDQVERGYRM PCPPECPESL
510 520 530 540
HDLMCQCWRK DPEERPTFEY LQAFLEDYFT STEPQYQPGE NL
Length:542
Mass (Da):60,219
Last modified:November 2, 2010 - v1
Checksum:iBBD12F8F13965679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02036548 Genomic DNA No translation available.
RefSeqiNP_001104274.1, NM_001110804.1
XP_010809813.1, XM_010811511.2
UniGeneiBt.61976

Genome annotation databases

EnsembliENSBTAT00000011767; ENSBTAP00000011767; ENSBTAG00000008938
GeneIDi535742
KEGGibta:535742

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02036548 Genomic DNA No translation available.
RefSeqiNP_001104274.1, NM_001110804.1
XP_010809813.1, XM_010811511.2
UniGeneiBt.61976

3D structure databases

ProteinModelPortaliE1BIM8
SMRiE1BIM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011767

PTM databases

iPTMnetiE1BIM8

Proteomic databases

PaxDbiE1BIM8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011767; ENSBTAP00000011767; ENSBTAG00000008938
GeneIDi535742
KEGGibta:535742

Organism-specific databases

CTDi6714
VGNCiVGNC:35269 SRC

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
InParanoidiE1BIM8
KOiK05704
OMAiCQCWRKD
OrthoDBiEOG091G0D46
TreeFamiTF351634

Enzyme and pathway databases

ReactomeiR-BTA-1227986 Signaling by ERBB2
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-1295596 Spry regulation of FGF signaling
R-BTA-1433557 Signaling by SCF-KIT
R-BTA-1433559 Regulation of KIT signaling
R-BTA-180292 GAB1 signalosome
R-BTA-186763 Downstream signal transduction
R-BTA-191647 c-src mediated regulation of Cx43 function and closure of gap junctions
R-BTA-2029481 FCGR activation
R-BTA-354192 Integrin alphaIIb beta3 signaling
R-BTA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-BTA-372708 p130Cas linkage to MAPK signaling for integrins
R-BTA-389356 CD28 co-stimulation
R-BTA-389513 CTLA4 inhibitory signaling
R-BTA-3928662 EPHB-mediated forward signaling
R-BTA-3928663 EPHA-mediated growth cone collapse
R-BTA-3928664 Ephrin signaling
R-BTA-3928665 EPH-ephrin mediated repulsion of cells
R-BTA-418592 ADP signalling through P2Y purinoceptor 1
R-BTA-418885 DCC mediated attractive signaling
R-BTA-430116 GP1b-IX-V activation signalling
R-BTA-437239 Recycling pathway of L1
R-BTA-4420097 VEGFA-VEGFR2 Pathway
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-5218921 VEGFR2 mediated cell proliferation
R-BTA-5607764 CLEC7A (Dectin-1) signaling
R-BTA-5673000 RAF activation
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-69231 Cyclin D associated events in G1
R-BTA-8853659 RET signaling
R-BTA-8874081 MET activates PTK2 signaling
R-BTA-8934903 Receptor Mediated Mitophagy
R-BTA-8941858 Regulation of RUNX3 expression and activity
R-BTA-9603381 Activated NTRK3 signals through PI3K

Gene expression databases

BgeeiENSBTAG00000008938 Expressed in 10 organ(s), highest expression level in colon

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE1BIM8_BOVIN
AccessioniPrimary (citable) accession number: E1BIM8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 12, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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