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Entry version 61 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

ELM2 and Myb/SANT domain containing 1

Gene

MIDEAS

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ELM2 and Myb/SANT domain containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIDEASImported
Synonyms:ELMSAN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:28444, MIDEAS

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BI11

PRoteomics IDEntifications database

More...
PRIDEi
E1BI11

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E1BI11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000009272, Expressed in lung and 18 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000012216

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini720 – 812ELM2InterPro annotationAdd BLAST93
Domaini827 – 878SANTInterPro annotationAdd BLAST52
Domaini1037 – 1064C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 70DisorderedSequence analysisAdd BLAST70
Regioni94 – 151DisorderedSequence analysisAdd BLAST58
Regioni233 – 263DisorderedSequence analysisAdd BLAST31
Regioni410 – 441DisorderedSequence analysisAdd BLAST32
Regioni541 – 608DisorderedSequence analysisAdd BLAST68
Regioni886 – 1035DisorderedSequence analysisAdd BLAST150
Regioni1052 – 1102DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 45Pro-richSequence analysisAdd BLAST18
Compositional biasi119 – 141PolarSequence analysisAdd BLAST23
Compositional biasi249 – 263PolarSequence analysisAdd BLAST15
Compositional biasi549 – 566PolyampholyteSequence analysisAdd BLAST18
Compositional biasi590 – 604PolyampholyteSequence analysisAdd BLAST15
Compositional biasi893 – 908PolyampholyteSequence analysisAdd BLAST16
Compositional biasi918 – 965PolyampholyteSequence analysisAdd BLAST48
Compositional biasi967 – 985PolarSequence analysisAdd BLAST19
Compositional biasi1005 – 1028PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1054 – 1072PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4167, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011395_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BI11

Database of Orthologous Groups

More...
OrthoDBi
165439at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448, ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1BI11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLQAQPKAQ NKRKRCLFGD QEPAPKEQPQ PLQAPQQPPA PPQSRVKEEP
60 70 80 90 100
YFAHEGSAGA APHSQPVELP SSNSLALLNS VVYGSERTML SQQVGSVKWP
110 120 130 140 150
NSVMAPGRGP ERGGGGGVSD SGWQQQPGQP PPNSTWNRHS LPLYSGPKGS
160 170 180 190 200
SHPGMGVATY YNHPEPLKLE KVGGPQLDRY GNAVRPMVPP KVQLEVGRSQ
210 220 230 240 250
APLNSFHMAK KPPNQTLPLE SFRQAFGHQV NRQVFRQGPP PPNPVTAFPP
260 270 280 290 300
QKQQQQQQQQ QAALPQIQLL ENFYSMQQPP PSQQPQDFGL QPAGPLGQSH
310 320 330 340 350
LAHHSMAPYH FPPNPDMNPE LRKALLQESA PQPVLPQAQI AFPRRSRRLS
360 370 380 390 400
KEGVLPSTAL DGAGTQPGQE PASNLFLHHW VPQQPPPGPL GQPHPEALGF
410 420 430 440 450
TLELRESQFL SDGERLAPNG RERETPAMGG EEGMRAVGTG DCGQVLRGGV
460 470 480 490 500
IQSTRRRRRA SQEANLLTLA QKAVELASLQ NTKDASGSEE KRKSVLASTT
510 520 530 540 550
KCGVEFSEPA LAKRAREDSG MVPLIIPVSV PVRAVDPTEA AQAGGVDEDG
560 570 580 590 600
KGPEQHPAEH KPSVIVTRRR STRIPGTDAP AQPEDMNVKL EGEPSVRKPK
610 620 630 640 650
QRPRPEPLII PTKAGTFIAP PVYSNITPYQ SHLRSPVRLA DHPSERSFEL
660 670 680 690 700
PPYTPPPILS PVREGSGLYF NAIMSTSSIP APPPITPKSA HRTLLRSNSA
710 720 730 740 750
EVTPPVLSVM GEATPVSIEP RINVGSRFQA EIPSMRDRAL AAADPHKADL
760 770 780 790 800
VWQPWEVLES SREKQRQVED LLTAACSSIF PGAGTNQELA LHCLHESRGD
810 820 830 840 850
ILETLNKLLL KKPLRPHNHP LATYHYTGSD QWKMAERKLF NKGIAIYKKD
860 870 880 890 900
FFLVQKLIQT KTVAQCVEFY YTYKKQVKIG RNGTLTFGDV DTSDEKSAQE
910 920 930 940 950
EVEVDIKTSQ KFPRVPPPRR ESPNEERLEP KKEEKETRKE GEEEMPETQD
960 970 980 990 1000
KGEQEEGRER SRRAAAVKAT QTLQANESAN DILILRSHES NAPGSAGGQA
1010 1020 1030 1040 1050
SEKPREGPGK SRRALPFSEK KKKTETFNKT QNQENTFPCK KCGRVFFKVK
1060 1070 1080 1090 1100
SRSAHMKSHA EQEKKAAALR QKEKEAAAAA ATAAASPHQP ALREESGAGE

RG
Length:1,102
Mass (Da):120,962
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC95AE2B7DBCE6EEB
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_005193794.1, XM_005193737.3
XP_005193795.1, XM_005193738.3
XP_005212176.1, XM_005212119.3
XP_005212177.1, XM_005212120.2
XP_010807900.1, XM_010809598.2
XP_010811428.1, XM_010813126.2
XP_015320708.1, XM_015465222.1
XP_015320709.1, XM_015465223.1
XP_015328768.1, XM_015473282.1
XP_015328769.1, XM_015473283.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000012216; ENSBTAP00000012216; ENSBTAG00000009272

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
505848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:505848

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_005193794.1, XM_005193737.3
XP_005193795.1, XM_005193738.3
XP_005212176.1, XM_005212119.3
XP_005212177.1, XM_005212120.2
XP_010807900.1, XM_010809598.2
XP_010811428.1, XM_010813126.2
XP_015320708.1, XM_015465222.1
XP_015320709.1, XM_015465223.1
XP_015328768.1, XM_015473282.1
XP_015328769.1, XM_015473283.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012216

PTM databases

iPTMnetiE1BI11

Proteomic databases

PaxDbiE1BI11
PRIDEiE1BI11

Genome annotation databases

EnsembliENSBTAT00000012216; ENSBTAP00000012216; ENSBTAG00000009272
GeneIDi505848
KEGGibta:505848

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91748
VGNCiVGNC:28444, MIDEAS

Phylogenomic databases

eggNOGiKOG4167, Eukaryota
GeneTreeiENSGT00940000157459
HOGENOMiCLU_011395_0_0_1
InParanoidiE1BI11
OrthoDBi165439at2759
TreeFamiTF106431

Gene expression databases

BgeeiENSBTAG00000009272, Expressed in lung and 18 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BI11_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BI11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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