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Entry version 58 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

AF4/FMR2 family member 1

Gene

AFF1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:25710, AFF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BHU6

PRoteomics IDEntifications database

More...
PRIDEi
E1BHU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000018488, Expressed in muscle tissue and 99 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1BHU6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000024607

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini959 – 1220AF-4_CInterPro annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni69 – 333DisorderedSequence analysisAdd BLAST265
Regioni373 – 967DisorderedSequence analysisAdd BLAST595
Regioni1108 – 1131DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 52Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi69 – 86Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi168 – 191Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi213 – 241Polar residuesSequence analysisAdd BLAST29
Compositional biasi318 – 333Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi378 – 433Polar residuesSequence analysisAdd BLAST56
Compositional biasi471 – 493Polar residuesSequence analysisAdd BLAST23
Compositional biasi517 – 537Polar residuesSequence analysisAdd BLAST21
Compositional biasi557 – 574Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi593 – 614Polar residuesSequence analysisAdd BLAST22
Compositional biasi652 – 705Basic and acidic residuesSequence analysisAdd BLAST54
Compositional biasi740 – 754Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi792 – 844Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi876 – 891Polar residuesSequence analysisAdd BLAST16
Compositional biasi918 – 934Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi935 – 955Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR32, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BHU6

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAMFRY

Database of Orthologous Groups

More...
OrthoDBi
558558at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1BHU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQSSLYNE DRNLLRIREK ERRNQEAHQD KEAFSEKIPL FGEPYKTEKG
60 70 80 90 100
DELSSRIQNM LGNYEEMKEF LSSKSHPQRL DASENRLGKP RYPLFPEKGS
110 120 130 140 150
SLPPHSFHTS VHHQPVNTPA CGPHPAGNIG HHPKMAQPRM EPMPSLHAKS
160 170 180 190 200
YGPPDSQHLT QERLGQEGYG SSHHKKGDRR ADGDHCALTT DSAPERELSP
210 220 230 240 250
LFSLPSPVPP LSPVHSNQQT APRTQGSGKV PSSSSSNKGY CLAKSPKDLA
260 270 280 290 300
VKVHDKETPQ DSTGAVASLG VAPPQPPSQT FPPPSLPSKS LAMQQKPTAY
310 320 330 340 350
VRPMDGQDQA PSESPELKPL PEEYRQQTFE KSDLKVPAKA KLTKLKMPSQ
360 370 380 390 400
SVEQTYSNEV HCVEEILKEM THSWPPPLTA IHTPSTAEPS KFPFPTKDSQ
410 420 430 440 450
HISSAVPNQK QYDTSSKTHS NSQQGTSSML KDDLQLSDSE DSDSDQTSEK
460 470 480 490 500
PPFAPAPPSA PPALPAAAAS AHSSSAESES TSDSDSSSDS ESESSSSDSE
510 520 530 540 550
ENEPREAPAP EPEPPTTNKW QLDNWLTKVS QPAVPTEAPG STEPPARPPD
560 570 580 590 600
TKGKGGDSAT AGHERPESKE PPPKGSSKAP RVPSEGPHAG KRSCQKSPTQ
610 620 630 640 650
QEPPQRQTVG SKQPKKPIKA SAPGHADAPA DARACLQVES EPGLPPPASR
660 670 680 690 700
DQPSKDKPKV KTKGRPRAAD SREPKPAVPT PSDRKKHRSG PPKAPPKDAA
710 720 730 740 750
AEDRSPEHFA LVPLTQSQGP VRGGSGGAGA RTSGCRLAVV VQEDRRKDKP
760 770 780 790 800
PVPSRDTKLL SPLRDAPPPQ SLVVKITLDL LSRIPQPPGK GSRPKKPEDK
810 820 830 840 850
QPPAGKKPDP EKRSSENASK LAKKRKGEAE KDHDSKKVRL EKEVKSQPLS
860 870 880 890 900
SSSHKESSKS KMSRPSSEPS KKEMLPPSLV SSSSSQKPAK PAQKRPRQED
910 920 930 940 950
PGCQDPQKSA GSAKGSHRDP SASKHRKAEG KVSGSSTEHK GSSGDTANRF
960 970 980 990 1000
PVPSLPNGNS KPGKPHVKFD KQQADFHLKE AKRLKDKAEL VTDKVGKAFK
1010 1020 1030 1040 1050
YLEAALSFIE CGVALESESP ASKSAYSIYS ETVDLIKFIL SLKSFSDATT
1060 1070 1080 1090 1100
PTQEKIFAVL CMRCQSILNM AMFRCKKDMA IKYSRTLNEH FFKTSSKVAQ
1110 1120 1130 1140 1150
APSPCIASTG TPSPLSPIPS PASSIGSQSS AGSVGSGALP ATISTPVTIQ
1160 1170 1180 1190 1200
NMTSSYVSIT SHVLTAFDLW EQAEVLTRKN KEFFAQLSTS VCALALNSSL
1210 1220
MDLVHYTRQG FQRLKQVTKT P
Length:1,221
Mass (Da):131,770
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8B962000D72090C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MG66A0A3Q1MG66_BOVIN
AF4/FMR2 family member 1
AFF1
1,228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000024607; ENSBTAP00000024607; ENSBTAG00000018488

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024607

Proteomic databases

PaxDbiE1BHU6
PRIDEiE1BHU6

Genome annotation databases

EnsembliENSBTAT00000024607; ENSBTAP00000024607; ENSBTAG00000018488

Organism-specific databases

VGNCiVGNC:25710, AFF1

Phylogenomic databases

eggNOGiENOG502QR32, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiE1BHU6
OMAiYMAMFRY
OrthoDBi558558at2759
TreeFamiTF326216

Gene expression databases

BgeeiENSBTAG00000018488, Expressed in muscle tissue and 99 other tissues
ExpressionAtlasiE1BHU6, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BHU6_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BHU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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