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Entry version 60 (02 Jun 2021)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene

TCOF1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCOF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:35700, TCOF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BHU1

PRoteomics IDEntifications database

More...
PRIDEi
E1BHU1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E1BHU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000015224, Expressed in leukocyte and 96 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1BHU1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000020259

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1BHU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 1040DisorderedSequence analysisAdd BLAST984
Regioni1052 – 1261DisorderedSequence analysisAdd BLAST210
Regioni1300 – 1458DisorderedSequence analysisAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi105 – 126Polar residuesSequence analysisAdd BLAST22
Compositional biasi157 – 208Polar residuesSequence analysisAdd BLAST52
Compositional biasi401 – 415Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi416 – 450Polar residuesSequence analysisAdd BLAST35
Compositional biasi496 – 513Polar residuesSequence analysisAdd BLAST18
Compositional biasi565 – 592Polar residuesSequence analysisAdd BLAST28
Compositional biasi602 – 618Polar residuesSequence analysisAdd BLAST17
Compositional biasi706 – 734Polar residuesSequence analysisAdd BLAST29
Compositional biasi947 – 970Polar residuesSequence analysisAdd BLAST24
Compositional biasi1014 – 1040Polar residuesSequence analysisAdd BLAST27
Compositional biasi1058 – 1092Polar residuesSequence analysisAdd BLAST35
Compositional biasi1101 – 1138Polar residuesSequence analysisAdd BLAST38
Compositional biasi1169 – 1192Polar residuesSequence analysisAdd BLAST24
Compositional biasi1200 – 1216Polar residuesSequence analysisAdd BLAST17
Compositional biasi1300 – 1342Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi1349 – 1383Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi1410 – 1432Basic residuesSequence analysisAdd BLAST23
Compositional biasi1443 – 1458Basic residuesSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S41N, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_263315_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BHU1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFPECDP

Database of Orthologous Groups

More...
OrthoDBi
614008at2759

TreeFam database of animal gene trees

More...
TreeFami
TF341730

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E1BHU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYQHLLQ AGYVRAAREV KEQSGQKIFL SQPVTLLDIY
60 70 80 90 100
THWQQTSEIG RKRKAEEDAA LQAKRSRVSD PISSSESSEE EEEEEEAEAK
110 120 130 140 150
TTKPTPRLAA TNSSVTGTVS SSNVKEKAKA KTTKASKTVN STTHPAPGKA
160 170 180 190 200
VAHLLTGKSP QKTSGPSANA VLVSETEEEG SVSALRTATT PGMASADQAD
210 220 230 240 250
SSSEDTTSSS DETDLEAKAA VKPLQVRASA TAVKESPRKS AAPTPGKAGV
260 270 280 290 300
VTPQVRGGAV TPASRAKKPE EVSESSEESD ESEEAAPAGT PSQVKALEKT
310 320 330 340 350
VPIRVAPSPA KGTPGKGATP APPGKAGPLG KPEEDSESSS EESDSEEETQ
360 370 380 390 400
AVKTPVQAKP SGKIPQVKAA STPKIQVFFP KKGSPPTSPG KAGPAATQAQ
410 420 430 440 450
PRKQEEEESS SSSSKESDSE GEVPTAMQQT TSLAQAKPLE KNSQVRAASA
460 470 480 490 500
TGAGPSAKGT VPALPQKARS VAAQDGKQED SESSSEEESD SEEEMQKAGT
510 520 530 540 550
SAQAQSSGKA LQIRPASGPT KRPPQKAGPA TTQVKVERAE EDSESSEEES
560 570 580 590 600
DSEDEAPVAK TPAQAKSAVK TSQIKASPRK GTPITPSSAR VPPVQVGTPA
610 620 630 640 650
PRTAAAVSTP TCASSPAIVR HTQKPGEDSS SSEESESEEE TAPAAAGGQM
660 670 680 690 700
KSIGKTLPVK AASPATKGPS GKGTTPGPPG KAGPAVAQVK AEVQEDSESS
710 720 730 740 750
EESDNEEAAA TPAQVKTSVK TPQTKANSSA TRVASAKAAA PAPGKGGLAV
760 770 780 790 800
AQAKVGSPAK VKPPARTPQS SAVSGRGQVS VPAVGKAAAA AAQAQPGPVK
810 820 830 840 850
GSQEDSESSE EESDSEGEAP PQGKPSGKTP QVRTASAPTK ASPKKGAAPV
860 870 880 890 900
PPGKAGPPAT QAKRQEEDSE SSSEEESDSD GDVPAAAPPA QKEGSSKTAT
910 920 930 940 950
SKTLAPASLE KKAEESSTSS DEDLPSSQVI KTPLIFVDPN RSPAGPAATP
960 970 980 990 1000
AQAQATGTLR KAQALESTAR SSSESEDEDV IPATQCPTPA TRTSVVTVPT
1010 1020 1030 1040 1050
APPKAALRAS VVGAPSSEDT SQGSEGKKQE ASATQVTKRN LPLTQAALKV
1060 1070 1080 1090 1100
LAQKASEAQS PAAKTPSSSG TDSAVGTLST ASPQSTPTQV RMANKLRKPE
1110 1120 1130 1140 1150
VPTAQQATAT PSGHPTAKAP ATSDDSNSSS SGSEDDAKGS QAAPSAHRPG
1160 1170 1180 1190 1200
PAPSRRETLV EETTTESSDD EVVAPSQSLL SGFVTPGLTP AGSKTSKAAP
1210 1220 1230 1240 1250
KPDASPSVSS TPATRDAPEG KQEVEPQQAA GTMSPKTGRK EAGATPQKPG
1260 1270 1280 1290 1300
KGLGSPPASM LALQSNITQR LLSEPWPLSE AQVQASVAKV LTELLEQERK
1310 1320 1330 1340 1350
KAMDTAKEGS RKGRLGHKRK LSEDQTAPKA PKNKKKKQLA AADGGEHVVS
1360 1370 1380 1390 1400
SEKAPRTVKG KSKKDRASGD VKEKKEKESP GSQGAKEKPV GELGTPKGDG
1410 1420 1430 1440 1450
GDHGNLKMKK EKKKSDKKKK DKEKKEKKKK AKKASTKDPG SPSQKKKKRK

KKTAEQTV
Length:1,458
Mass (Da):149,529
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3B3DD9C95E1EF91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LFY9A0A3Q1LFY9_BOVIN
Treacle ribosome biogenesis factor ...
TCOF1
1,351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LX56A0A3Q1LX56_BOVIN
Treacle ribosome biogenesis factor ...
TCOF1
1,394Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_002689339.2, XM_002689293.5
XP_010796812.1, XM_010798510.2
XP_010805819.1, XM_010807517.2
XP_591291.5, XM_591291.9

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000020259; ENSBTAP00000020259; ENSBTAG00000015224

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
513591

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:513591

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_002689339.2, XM_002689293.5
XP_010796812.1, XM_010798510.2
XP_010805819.1, XM_010807517.2
XP_591291.5, XM_591291.9

3D structure databases

SMRiE1BHU1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020259

PTM databases

iPTMnetiE1BHU1

Proteomic databases

PaxDbiE1BHU1
PRIDEiE1BHU1

Genome annotation databases

EnsembliENSBTAT00000020259; ENSBTAP00000020259; ENSBTAG00000015224
GeneIDi513591
KEGGibta:513591

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6949
VGNCiVGNC:35700, TCOF1

Phylogenomic databases

eggNOGiENOG502S41N, Eukaryota
GeneTreeiENSGT00730000111382
HOGENOMiCLU_263315_0_0_1
InParanoidiE1BHU1
OMAiDFPECDP
OrthoDBi614008at2759
TreeFamiTF341730

Gene expression databases

BgeeiENSBTAG00000015224, Expressed in leukocyte and 96 other tissues
ExpressionAtlasiE1BHU1, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 1 hit
PfamiView protein in Pfam
PF03546, Treacle, 3 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BHU1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BHU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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