UniProtKB - E1BG38 (E1BG38_BOVIN)
Protein
Submitted name:
Rho guanine nucleotide exchange factor 1
Gene
ARHGEF1
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Molecular functioni
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
Keywordsi
Molecular function | GTPase activationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Rho guanine nucleotide exchange factor 1Imported |
Gene namesi | Name:ARHGEF1Imported |
Organismi | Bos taurus (Bovine)Imported |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:52179, ARHGEF1 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmARBA annotation, MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSBTAG00000018912, Expressed in spleen and 18 other tissues |
ExpressionAtlasi | E1BG38, baseline and differential |
Interactioni
GO - Molecular functioni
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000025175 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 476 – 665 | DHInterPro annotationAdd BLAST | 190 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 459 | DisorderedSequence analysisAdd BLAST | 225 | |
Regioni | 824 – 861 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 901 – 926 | DisorderedSequence analysisAdd BLAST | 26 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 927 – 950 | Sequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 235 – 265 | PolyampholyteSequence analysisAdd BLAST | 31 | |
Compositional biasi | 278 – 299 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 367 – 400 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 435 – 458 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 840 – 854 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3520, Eukaryota |
GeneTreei | ENSGT00940000161180 |
HOGENOMi | CLU_003962_2_0_1 |
InParanoidi | E1BG38 |
OrthoDBi | 319635at2759 |
TreeFami | TF106495 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E1BG38-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAEAIPPLP QAPGPPRPGL APVSIIGAED EDFEIELKTN PEEQNNQFQN
60 70 80 90 100
LDQVKRRPAH LMALLQHVAM QFEPGPLLCC LHADMLGSLG PKEFKKAFID
110 120 130 140 150
FYHSFLDKHS ILRVMVPPAV AFELDRTRPD LFPEDLQRQF VQEVVQSQQV
160 170 180 190 200
AVVRQLEDFR SKKLMGMTPW EQELVQLGAW VARDRASYEA RERHLAERQL
210 220 230 240 250
THLEEMQHTI SNDEEKSAAV VNAISMYMRH LGVRTKSGDK KSGRNFFRKK
260 270 280 290 300
MIGNRRSDEP TKTKKGLSSF LDAARWNRGE PQDFRHPKVE VDAEKPGLTE
310 320 330 340 350
RKGGQGAPSR DRNLGGPGQD TPGVSPHLLS GDSPDREPGV DALLEVGDPP
360 370 380 390 400
PQGPASLDAP APLESTEEAA DTERKWKRLS GRLGRSESLR VSDRRRPSRG
410 420 430 440 450
SLGAKGRGGG RSRSDVDMDP SSATAVLGPT RRATPEPGDE GEPGRSGLEL
460 470 480 490 500
EPEEPPGWRE LVPQDILHSL PKSQVKRQEV ISELLVTEAA HVRMLRVLHD
510 520 530 540 550
VFYQPIADGG FYSQEELQNI FPSLDELIEV HSLFLDSLMK RRQDSGYLIK
560 570 580 590 600
EIGDVLLARF DGAEGSWFQK ISSRFCSRQS FALEQLKAKQ RKEPRFCTFV
610 620 630 640 650
QEAESRPRCR RLQLKDMIPT EMQRLTKYPL LLQSIEQNTE EPVEREKVER
660 670 680 690 700
AAECCREILQ HVNLAVRDME DLLRLKDYQR RLDLTHLRQS NDPMLSEFKN
710 720 730 740 750
LDITKKRLIY EGPLTWRVTK DKAVEVHVLL LDDLLLLLQR QDERFLLKSH
760 770 780 790 800
SRTLTPTPDG KTMLRPVLRL TSAMTREVAT DHKAFYVIFT WDQEAQIYEL
810 820 830 840 850
VAQTVSERRI WCTLITETAG CLKVPSRTSR PKHRPGPSST REPLLSSSEN
860 870 880 890 900
GNGSREMPPA DGRMERLFNS LLPFCRQGLE GQLAAKALQK VLTLKQLLLP
910 920 930 940 950
SEEDSGAGPP LEGDGVPGGS PLSPTQPQEI REELLSLEET IKQLEEVEEE
960 970
FCRLRLLLSQ LGENTVPQSG CT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LFQ5 | A0A3Q1LFQ5_BOVIN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 988 | Annotation score: | ||
A0A3Q1MSE0 | A0A3Q1MSE0_BOVIN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 967 | Annotation score: | ||
A0A3Q1NB40 | A0A3Q1NB40_BOVIN | Rho guanine nucleotide exchange fac... | ARHGEF1 | 946 | Annotation score: |
Genome annotation databases
Ensembli | ENSBTAT00000025175; ENSBTAP00000025175; ENSBTAG00000018912 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000025175 |
Proteomic databases
PaxDbi | E1BG38 |
PRIDEi | E1BG38 |
Genome annotation databases
Ensembli | ENSBTAT00000025175; ENSBTAP00000025175; ENSBTAG00000018912 |
Organism-specific databases
VGNCi | VGNC:52179, ARHGEF1 |
Phylogenomic databases
eggNOGi | KOG3520, Eukaryota |
GeneTreei | ENSGT00940000161180 |
HOGENOMi | CLU_003962_2_0_1 |
InParanoidi | E1BG38 |
OrthoDBi | 319635at2759 |
TreeFami | TF106495 |
Gene expression databases
Bgeei | ENSBTAG00000018912, Expressed in spleen and 18 other tissues |
ExpressionAtlasi | E1BG38, baseline and differential |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E1BG38_BOVIN | |
Accessioni | E1BG38Primary (citable) accession number: E1BG38 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 2, 2010 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |