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Protein

Eyes absent homolog

Gene

EYA4

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-BTA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homologUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:EYA4Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:28673 EYA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE1BD15

Expressioni

Gene expression databases

BgeeiENSBTAG00000021970

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029290

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. EYA family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3107 Eukaryota
ENOG410XT12 LUCA
GeneTreeiENSGT00390000008860
InParanoidiE1BD15
OMAiQSVKKTC
OrthoDBiEOG091G04YD
TreeFamiTF319337

Family and domain databases

CDDicd02601 HAD_Eya, 1 hit
Gene3Di3.40.50.12350, 1 hit
InterProiView protein in InterPro
IPR028478 EYA4
IPR006545 EYA_dom
IPR038102 EYA_dom_sf
IPR028472 EYA_fam
PANTHERiPTHR10190 PTHR10190, 1 hit
PTHR10190:SF17 PTHR10190:SF17, 1 hit
TIGRFAMsiTIGR01658 EYA-cons_domain, 1 hit

Sequencei

Sequence statusi: Complete.

E1BD15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SNRSMEMQDL ASPHPLVGGG DTPGSSKLEK TNLSSTSVTT NGTGGDNMTV
60 70 80 90 100
LNTADWLLSC NTPSSATMSL LAVKTEPLNS SETTATTGDG ALDTFTGSVI
110 120 130 140 150
TSSGYSPRSA HQYSPQLYPS KPYPHILSTP AAQTMSAYAG QTQYSGMQQP
160 170 180 190 200
AVYTAYSQTG QPYSLPTYDL GVMLPGIKTE SGLSQTQSPL QSGCLSYSPG
210 220 230 240 250
FSTPQPGQTP YSYQMPGSSF APSSTIYANN SVSNSTNFSG SQQDYPSYTA
260 270 280 290 300
FGQNQYAQYY SASTYGAYMT SNNTADGSSS TTSTYQLQES LPGLTSQPGT
310 320 330 340 350
DLHPGEFDTV QSPSTPIKDL DERTCRSSGS KSRGRGRKNN PSPPPDSDLE
360 370 380 390 400
RVFVWDLDET IIVFHSLLTG SYAQKYGKDP PMAVTLGLRM EEMIFNLADT
410 420 430 440 450
HLFFNDLEEC DQVHIDDVSS DDNGQDLRCC STYSFATDGF HAAASSANLC
460 470 480 490 500
LPTGVRGGVD WMRKLAFRYR RVKELYNTYK NNVGGLLGPA KRDAWLQLRA
510 520 530 540 550
EIEGLTDSWL TNALKSLSII STRSNCVNVL VTTTQLIPAL AKVLLYSLGG
560 570 580 590 600
AFPIENIYSA TKIGKESCFE RIMQRFGRKV VYVVIGDGVE EEQAAKKHNM
610 620
PFWRISSHSD LLALHQALEL EYL
Length:623
Mass (Da):67,588
Last modified:November 16, 2011 - v2
Checksum:i510A50F8B3D95AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02026688 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000029290; ENSBTAP00000029290; ENSBTAG00000021970

Similar proteinsi

Entry informationi

Entry nameiE1BD15_BOVIN
AccessioniPrimary (citable) accession number: E1BD15
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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