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Entry version 56 (18 Sep 2019)
Sequence version 2 (16 Nov 2011)
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Protein

Protein kinase domain-containing protein

Gene

PRAG1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAG1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 27

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BCY7

PRoteomics IDEntifications database

More...
PRIDEi
E1BCY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000000357 Expressed in 9 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1BCY7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini965 – 1331Protein kinaseInterPro annotationAdd BLAST367

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 98DisorderedSequence analysisAdd BLAST54
Regioni138 – 159DisorderedSequence analysisAdd BLAST22
Regioni225 – 258DisorderedSequence analysisAdd BLAST34
Regioni305 – 474DisorderedSequence analysisAdd BLAST170
Regioni490 – 850DisorderedSequence analysisAdd BLAST361
Regioni884 – 914DisorderedSequence analysisAdd BLAST31
Regioni1159 – 1206DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi337 – 361PolarSequence analysisAdd BLAST25
Compositional biasi394 – 408PolarSequence analysisAdd BLAST15
Compositional biasi446 – 460PolarSequence analysisAdd BLAST15
Compositional biasi559 – 584PolarSequence analysisAdd BLAST26
Compositional biasi600 – 625PolarSequence analysisAdd BLAST26
Compositional biasi674 – 693PolarSequence analysisAdd BLAST20
Compositional biasi731 – 785PolarSequence analysisAdd BLAST55
Compositional biasi829 – 850PolarSequence analysisAdd BLAST22
Compositional biasi1159 – 1189PolarSequence analysisAdd BLAST31

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJMD Eukaryota
ENOG4110SRP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157066

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BCY7

KEGG Orthology (KO)

More...
KOi
K17537

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHDESHF

Database of Orthologous Groups

More...
OrthoDBi
49921at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331193

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1BCY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLETIPLNPE SPKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVPGRPQPR
60 70 80 90 100
VGCLPPPPRL HPRPESDRPE DDGLSGSPYS KPTIAVKPTM MSSEASDGWT
110 120 130 140 150
EAGMSADVAQ VIWRRAPGKL PLPKQEDGPV VYLGSFRGVQ KPAGPSGPTD
160 170 180 190 200
GGHPRSPPAY AMVGLHSLEP RGDRSAAFHP VSFPDEKLGR DDKPVIPYQE
210 220 230 240 250
LNSPQESFRQ KLAAFSGMTS GCLKGLGPYP SAQPMRESLP SEDDSDQRCS
260 270 280 290 300
PSGDSEGGEY CSILDCCPGS PGAEDAARAG GSRHRQGGRD CSAACWEPRV
310 320 330 340 350
CARPPEEEKQ ALSFPRDCCS QGPTESPPRL GPKKQSLASE AASSSDGLSC
360 370 380 390 400
GSANSRASSP LAPHPESDYC SLRKEPGLGK QQDSGCHGVA SSRRLGQTGE
410 420 430 440 450
TQPPAHSREA AQSEPIYAES TKRKKAVPVP SRPQAKAEQG AGAPGQAQVR
460 470 480 490 500
TVNTWAQKAA SGWGQVREGP DAAPQMAATI TVMAAHPEED HRTIYLSSPD
510 520 530 540 550
SSVGVQWPRG PPSQQAPEAG GEEPSAGQGL GSRESRHRSA SETTAKGRPA
560 570 580 590 600
IPPKMSRSSP GGSPVSPSAY PLSDLSEGNS GTPGPQPPSK GPADPASSCR
610 620 630 640 650
ANGIPSSDSA RGPPPATSTS ALEQRRPRPQ AGAWSRQCRI EEEDEVEQDL
660 670 680 690 700
LSQSWGREVE NGPLDPASSS AWHRLRPTDG SSGQNSKAGT GMSKSASFAF
710 720 730 740 750
EFPKDRSGIE TFSPPPPPPK SRHLLKMNKS SSDLEKVSQG SAESLSPSFR
760 770 780 790 800
GVHVSFTTGS TDSLASDSRT CSDGGPSSEP AHSPTNSRKK LFAPVPFPSG
810 820 830 840 850
STEDVSPGDP LQPPPLPQKK LVSRAASSPD GFFWTQGSPK PRTASPKLNL
860 870 880 890 900
SHSETNVCAH EDSHFSYASG PGGRHQHVFS ASEPLEKTSK GSGHRGPVLG
910 920 930 940 950
LGGSKGLQGK GVSSASSSQL SVSSQASAGS TQLQLHSLLN SISSKEGTYA
960 970 980 990 1000
KLGGLYAQSL VRLVARCEDL FMGGQKKELH FSENNWSLFK LTCNKPCCDS
1010 1020 1030 1040 1050
GDAIYYCATC SEDPGSTYAV KICKTPEPKA ASYCSPSVPV HFNIQQDCGH
1060 1070 1080 1090 1100
FVASVPSSML TSPDAHKDPL SALPSHPPAQ EQDCVVVITR EVPHQTASDF
1110 1120 1130 1140 1150
VRDLAASHQS EPEVYERRVC FLLLQLCNGL EHLKEHGIIH RDLCLENLLL
1160 1170 1180 1190 1200
VHCAPQASPE PSTAASLPPT TTSPAPAATP SSGPSATVPT SVNPTPPAAP
1210 1220 1230 1240 1250
AFQGGSSEKH LPRLIISNFL KAKQKPGGTT NLQQKKSQAR LAPEIVSASQ
1260 1270 1280 1290 1300
YRKFDEFQTG ILIYELLHQP NPFEVRAQLR EQDYRQEDLP PLPALSLYSP
1310 1320 1330 1340 1350
GLQRLAHLLL EADPIKRIRI GEAKRVLQCL LWGPRRELVE PPGASEEVLC
1360 1370 1380 1390 1400
TTLHNWIDMK RALMMMKFAE KAVDRRRGVE LEDWLCCQYL ASAEPTALLQ

SLKLLQLL
Length:1,408
Mass (Da):150,233
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7626C7442C109653
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_005226091.1, XM_005226034.3
XP_005226093.1, XM_005226036.3
XP_010818599.1, XM_010820297.2
XP_010824401.2, XM_010826099.2
XP_015325221.1, XM_015469735.1
XP_015325222.1, XM_015469736.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000000463; ENSBTAP00000000463; ENSBTAG00000000357
ENSBTAT00000084626; ENSBTAP00000071508; ENSBTAG00000000357

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
533821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:533821

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_005226091.1, XM_005226034.3
XP_005226093.1, XM_005226036.3
XP_010818599.1, XM_010820297.2
XP_010824401.2, XM_010826099.2
XP_015325221.1, XM_015469735.1
XP_015325222.1, XM_015469736.1

3D structure databases

SMRiE1BCY7
ModBaseiSearch...

Proteomic databases

PaxDbiE1BCY7
PRIDEiE1BCY7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000463; ENSBTAP00000000463; ENSBTAG00000000357
ENSBTAT00000084626; ENSBTAP00000071508; ENSBTAG00000000357
GeneIDi533821
KEGGibta:533821

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
157285

Phylogenomic databases

eggNOGiENOG410IJMD Eukaryota
ENOG4110SRP LUCA
GeneTreeiENSGT00940000157066
InParanoidiE1BCY7
KOiK17537
OMAiVHDESHF
OrthoDBi49921at2759
TreeFamiTF331193

Gene expression databases

BgeeiENSBTAG00000000357 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BCY7_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BCY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: September 18, 2019
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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