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Entry version 85 (02 Jun 2021)
Sequence version 1 (02 Nov 2010)
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Protein
Submitted name:

ATP binding cassette subfamily A member 3

Gene

ABCA3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1369062, ABC transporters in lipid homeostasis
R-BTA-5683826, Surfactant metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP binding cassette subfamily A member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:50168, ABCA3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E1BCR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000014903, Expressed in Ammon's horn and 99 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000019840

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1BCR1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155289

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAFETEP

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E1BCR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLRQLALL LWKNYTLQKR KVLVTLLELF LPLLFSGILI WLRLKIQSEN
60 70 80 90 100
VPNATLYPSQ SIRELPLFFS FPPPGATWEL AYIPSQSEAV RTVVESVQRA
110 120 130 140 150
LVINLRARGF TSEKDFEDYI RYDNRSTNVL AALVFEHTFN HSRDPLPLAV
160 170 180 190 200
KYHLRFSYTR RNYMWTQTGS FFLKETEGWH TTSLFPLFPN PGPREPTSPD
210 220 230 240 250
GGEPGYIREG FLAVQHAVDR AIMHHHANAS AHQLFEKLTV IAKRFPYPPF
260 270 280 290 300
ISDPFLVAIQ YQLPLLLMLS FTYTSLSIIR AIVQEKEKKL KEYMRMMGLS
310 320 330 340 350
SWLLWTAWFL LFFLLLLVAV SFMTLLFCVK VKKDVAVLAH SDPTLVLVFL
360 370 380 390 400
ACFAVSSISF SFMVSTFFSK ANMAAAIGGF LYFFSYIPYF FVAPRYNWMT
410 420 430 440 450
LSQKLFSCLL SNVAMAMGAQ LIGKFEAKGT GIQWRDLLSP VNVDDDFTFG
460 470 480 490 500
QVLGMLLLDS VLYGLVAWYV EAVLPGQFGV PQPWYFFILP SYWCGRPRTA
510 520 530 540 550
LGKEEEDDDP EKVLRTEYFE AEPEDLVAGI KIKHVSKVFR VGNKGKAAVR
560 570 580 590 600
DLNLNLYEGQ ITVLLGHNGA GKTTTLSMLT GLFPPTSGRA YISGYEVSQD
610 620 630 640 650
MDQIRKSLGL CPQHDVLFDD LTVAEHLYFY AQLKGLPRQK CPEEVKRMLH
660 670 680 690 700
VLGLEEKRDS RSRFLSGGMR RKLSIGIALI AGSKVLMLDE PTSGVDAISR
710 720 730 740 750
RAIWDLLQQH KSDRTILLTT HFMDEADLLG DRIAIMAKGE LQCCGSSLFL
760 770 780 790 800
KEKYGAGYHM TLVKEPHCNP EGISRLVQHH VPNATLESSA GAELSFILPK
810 820 830 840 850
ESTHRFESLF AKLEKKQKEL GIASFGASVT TMEEVFLRVG KLVDSSMDIQ
860 870 880 890 900
AIQLPALQYQ HERRASDWAV DGHLCGTMDP TDGVGALIEE ECTAVRLNTG
910 920 930 940 950
LALHCQQFWA MFLKKATYSW REWKVAAAQV LVPVTCLTLA LLAINYSSEI
960 970 980 990 1000
FDDPLLKLTL GEYGHTVVPF SVPGTSRLDQ QLSEHLKDML QAEGQEPREV
1010 1020 1030 1040 1050
LGDLEEFLIF RASVEGGGFN ERCLVAASFR DTGERTVITA LFNNQAYHSP
1060 1070 1080 1090 1100
ATVLAVVDNL LFKLLCGPRA SITVSNFPQP RSALQAAKDQ FNEGRKGFDI
1110 1120 1130 1140 1150
ALNLLFAMAF LASTFSILAV SERAIQAKHV QFVSGVHVAI FWLSALLWDL
1160 1170 1180 1190 1200
LSFLIPSLLL LVVFKAFDVH AFTRDGHVAD ALLLLTLYGW AIIPLMYLMS
1210 1220 1230 1240 1250
FFFSGAATAY TRLTIFNILS GIATFLVVTI MRIPAVKLEE LSRTLDRVFL
1260 1270 1280 1290 1300
VLPNHCLGMA VSNFYENYET RRYCTSSDVA AHYCRKYNIQ YQENFYAWST
1310 1320 1330 1340 1350
PGVGRFVTSM AASGFAYLTL LFLVEADLLW RLKTCLCAFQ RRRALTEVYT
1360 1370 1380 1390 1400
RTAALPEDQD VMDERNRILS PSLDSLLDTP LIIKELSKVY EQRAPLLAVD
1410 1420 1430 1440 1450
KVSLAVQKGE CFGLLGFNGA GKTTTFKMLT GEETITSGDA FVGGYSISSD
1460 1470 1480 1490 1500
IGKVRQRIGY CPQFDALLDH MTGRETLVMF ARLRGIPERH IGACVENTLR
1510 1520 1530 1540 1550
GLLLEPHANK LVRMYSGGNK RKLSTGIALL GEPAVIFLDE PSTGMDPVAR
1560 1570 1580 1590 1600
RLLWDTVARA RESGKAIVIT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH
1610 1620 1630 1640 1650
LKSKFGSGYS LRAKIRSDGQ QEALEEFKAF VGLTFPGSVL EDEHQGMVHY
1660 1670 1680 1690 1700
HLPGDDLSWA KVFGVLEKAT EKYGVDDYSV SQTSLEQVFL SFAHVQPPTE

DAGP
Length:1,704
Mass (Da):190,935
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBFFF76CD9913B9A
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001107218.1, NM_001113746.1
XP_005224454.1, XM_005224397.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000019840; ENSBTAP00000019840; ENSBTAG00000014903

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
505787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:505787

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001107218.1, NM_001113746.1
XP_005224454.1, XM_005224397.3

3D structure databases

SMRiE1BCR1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019840

Proteomic databases

PRIDEiE1BCR1

Genome annotation databases

EnsembliENSBTAT00000019840; ENSBTAP00000019840; ENSBTAG00000014903
GeneIDi505787
KEGGibta:505787

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
21
VGNCiVGNC:50168, ABCA3

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000155289
HOGENOMiCLU_000604_19_1_1
OMAiNAFETEP
OrthoDBi131191at2759
TreeFamiTF105191

Enzyme and pathway databases

ReactomeiR-BTA-1369062, ABC transporters in lipid homeostasis
R-BTA-5683826, Surfactant metabolism

Gene expression databases

BgeeiENSBTAG00000014903, Expressed in Ammon's horn and 99 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BCR1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BCR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 2, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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