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Entry version 47 (13 Nov 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Anaphase promoting complex subunit 1

Gene

ANAPC1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Anaphase promoting complex subunit 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:25879 ANAPC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000027991 Expressed in 10 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1BAB6 baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1731 – 1890APC1_CInterPro annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 342DisorderedSequence analysisAdd BLAST24
Regioni373 – 396DisorderedSequence analysisAdd BLAST24
Regioni991 – 1012DisorderedSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1858 Eukaryota
ENOG410XQ83 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016757

Database of Orthologous Groups

More...
OrthoDBi
738153at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024990 Apc1
IPR041221 APC1_C

The PANTHER Classification System

More...
PANTHERi
PTHR12827 PTHR12827, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12859 ANAPC1, 1 hit
PF18122 APC1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

E1BAB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNFYEERAT MIAAGDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS
60 70 80 90 100
SDGAAGLVGS LQEVTIHEKQ KESWQLRKGV SEIGEEVDYD EELYMAGNMV
110 120 130 140 150
IWSKGSKSQA LAVYKAFTVD SPVQQALWCD FIISQDKSDK DYSSDEVERC
160 170 180 190 200
ICILQSSCIN MHSIEGKDYI ASLPFQVANV WPTKYGLLFE RSSSSCEVPP
210 220 230 240 250
GPPREPLPTL FSMLHPLDEI TPVVCKSGSL FGSSRVQYVV DHAMKIVFLH
260 270 280 290 300
TDPSIVMTYD TVQGLHSVWA LRRVKTEEGN VVLKFSEQGG TPQNVATSSS
310 320 330 340 350
LTAHLRSLSK GDSPVASPFQ NYSSIHSQSR SASSPSLHSR SPSISNMAAL
360 370 380 390 400
SRAHSPALGV YSFSGVQRFN LSSHNQSPKR HSFSHSPSSN SNGSFLAPET
410 420 430 440 450
EPIVPELCID HLWTETITRL RKKNSQASKV FITSDLCGQK FLCYLVESEL
460 470 480 490 500
QLRCVKFQES NDKTQLIFGS VTNIQAKDAA PVEKIDTMLV LESSGNLVLY
510 520 530 540 550
TGVVRVGKVF IPGLPAPSLT MSNTMPRPST PLDGVTTANP LSKLLGSLDE
560 570 580 590 600
VLVSPVPELR DSSKLHDSLY TEDCTFQQLG TYIHSIRDPV RNRVTLELSN
610 620 630 640 650
GSMVRITIPE IATSELVQTC LQAIKFILPK EIAVQMLVKW YSVHSAPGGP
660 670 680 690 700
SDHSEWNLFV TCLMNMMGYN TDRLAWTRNF DFEGSLSPVI APKKARPSET
710 720 730 740 750
GSDDDWEYLL NSDYHQNVES HLLNRSLCLS PLEVSQMKDE DFSQNLSLDS
760 770 780 790 800
STLLFTHIPA IFFVLHLVYE ELKLNTLMGE GVRSLVELLV QLARDLKLEP
810 820 830 840 850
YIDHYYRDYP TLVRTTGQVC AIDQGQTGSM QYPPFFTPEP PSIYQWVSSC
860 870 880 890 900
LKGEGVPPYP YLPGICERGR LVVLSIALYI LGDESSLSDE SSQYLSRITP
910 920 930 940 950
PKPQAEQEES RFSFRHSASV SSLGERLVVW MSNVGFTLRD LETLPFGIAL
960 970 980 990 1000
PIRDAIYHCR EQPASDWPEA VCLLIGRQDL SKQACEGNLP KGKSVLSSDV
1010 1020 1030 1040 1050
PSGTETEEED DGMNDMNQEV MSLIWSEDLR VQDVRRLLQS AHPVRVNVVQ
1060 1070 1080 1090 1100
YPELSDHEFI EEKENRLLQL CQRTMALPVG RGMFTLFSYH PVPTEPLPIP
1110 1120 1130 1140 1150
KLNLTGRAPP RNTTVDLNSG NIDVPPNMTS WASFHNGVAA GLKIAPASQI
1160 1170 1180 1190 1200
DSAWIVYNKP KHAELANEYA GFLMALGLNG HLTKLATLNI HDYLTKGHEM
1210 1220 1230 1240 1250
TSIGLLLGVA AAKLGTMDMS VTRLLSIHIP ALLPPTSTEL DVPHNVQVAA
1260 1270 1280 1290 1300
VVGIGLVYQG TAHRHTAEVL LAEIGRPPGP EMEYCTDRES YSLAAGLALG
1310 1320 1330 1340 1350
MVCLGHGSNL IGMSDLNVPE QLYQYMVGGH RRFQAGMHRE KHKSPSYQIK
1360 1370 1380 1390 1400
EGDTINVDVT CPGATLALAM IYLKTNNSVT AWLTSTLARC LILWDDILPN
1410 1420 1430 1440 1450
SKWVDSNVPQ IIRENSISLS EIELPCSEDL NLETLSQAHV YIIAGACLSL
1460 1470 1480 1490 1500
GFRFAGSENL SAFNCLHKFA KDFMTYLSAP NASVTGPYNL ETCLSVVLLS
1510 1520 1530 1540 1550
LAMVMAGSGN LKVLQLCRFL HMKTGGEMNY GFHLAHHMAL GLLFLGGGRY
1560 1570 1580 1590 1600
SLSTSNSSIA ALLCALYPHF PAHSTDNRLL CCLPLSRPFV FSVNRYHLQA
1610 1620 1630 1640 1650
LRHLYVLAAE PRLLVPVDVD TNMPCYALLE VTYKGTQWYE QTKEELMAPT
1660 1670 1680 1690 1700
LLPELHLLKQ IKVKGPRYWE LLIDLSKGTQ HLKSILSKDG VLYVKLRAGQ
1710 1720 1730 1740 1750
LSYKEDPMGW QSLLAQTVAN RNSEARAFKP ETISTFTSDP ALLSFAEYFC
1760 1770 1780 1790 1800
KPTVNVGQKQ ELLDLFSSVL YECVTQETPE MLPAYIAMDQ AVRRLGRREM
1810 1820 1830 1840 1850
SETSDLWQIK LVLEFFSSRS HQERLQNQPN RGLFMNSEFL PVVKCTTDNT
1860 1870 1880 1890 1900
LDQWLQAGGD RCVHAYLSGQ PCEESQLSML ACFLVYHSVP APQHLPSIGL
1910 1920 1930
EGSTSFAELL FKFKQLKMPV RALLRLAPLL LGNPQPMVM
Length:1,939
Mass (Da):215,396
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09D4B5B098B89F18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MC27A0A3Q1MC27_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3N2V4G3N2V4_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,934Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MLF2A0A3Q1MLF2_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LUL1A0A3Q1LUL1_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,791Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M1P5A0A3Q1M1P5_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,930Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MCB2A0A3Q1MCB2_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,905Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MGM0A0A3Q1MGM0_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MJP2A0A3Q1MJP2_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,743Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1N0U6A0A3Q1N0U6_BOVIN
Anaphase promoting complex subunit ...
ANAPC1
1,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000040371; ENSBTAP00000040146; ENSBTAG00000027991

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSBTAT00000040371; ENSBTAP00000040146; ENSBTAG00000027991

Organism-specific databases

VGNCiVGNC:25879 ANAPC1

Phylogenomic databases

eggNOGiKOG1858 Eukaryota
ENOG410XQ83 LUCA
GeneTreeiENSGT00390000016757
OrthoDBi738153at2759

Gene expression databases

BgeeiENSBTAG00000027991 Expressed in 10 organ(s), highest expression level in testis
ExpressionAtlasiE1BAB6 baseline

Family and domain databases

InterProiView protein in InterPro
IPR024990 Apc1
IPR041221 APC1_C
PANTHERiPTHR12827 PTHR12827, 1 hit
PfamiView protein in Pfam
PF12859 ANAPC1, 1 hit
PF18122 APC1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BAB6_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BAB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: November 13, 2019
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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