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Entry version 76 (29 Sep 2021)
Sequence version 2 (16 Nov 2011)
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Protein

[Histone H3]-trimethyl-L-lysine(9) demethylase

Gene

KDM4B

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorARBA annotation, DioxygenaseARBA annotation, Oxidoreductase
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
[Histone H3]-trimethyl-L-lysine(9) demethylaseARBA annotation (EC:1.14.11.66ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KDM4BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSBTAG00000015487

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:30528, KDM4B

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BA41

PRoteomics IDEntifications database

More...
PRIDEi
E1BA41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000015487, Expressed in leukocyte and 96 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1BA41, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000020586

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1BA41

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 57JmjNInterPro annotationAdd BLAST43
Domaini146 – 309JmjCInterPro annotationAdd BLAST164
Domaini814 – 927PHD-typeInterPro annotationAdd BLAST114
Domaini874 – 913SWIM-typeInterPro annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni381 – 665DisorderedSequence analysisAdd BLAST285
Regioni722 – 745DisorderedSequence analysisAdd BLAST24
Regioni1055 – 1099DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi381 – 401Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi459 – 481Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi482 – 496Basic residuesSequence analysisAdd BLAST15
Compositional biasi530 – 545Pro residuesSequence analysisAdd BLAST16
Compositional biasi609 – 623Polar residuesSequence analysisAdd BLAST15
Compositional biasi1073 – 1087Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JHDM3 histone demethylase family.ARBA annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0958, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001442_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BA41

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVECCLC

Database of Orthologous Groups

More...
OrthoDBi
1186832at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106449

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732, EPHD
IPR003347, JmjC_dom
IPR003349, JmjN
IPR040477, KDM4_Tudor_2
IPR002999, Tudor
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR013083, Znf_RING/FYVE/PHD
IPR007527, Znf_SWIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02373, JmjC, 1 hit
PF02375, JmjN, 1 hit
PF18104, Tudor_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SM00249, PHD, 2 hits
SM00333, TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805, EPHD, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS50966, ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E1BA41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSEDHGAQN PSCKIMTFRP TMEEFKDFNK YVAYIESQGA HRAGLAKIIP
60 70 80 90 100
PKEWKPRQTY DDIDDVVIPA PIQQVVTGQS GLFTQYNIQK KAMTVGEYRR
110 120 130 140 150
LANSEKYCTP RHQDFDDLER KYWKNLTFVS PIYGADISGS LYDDDVAQWN
160 170 180 190 200
IGNLRTILDM VERECGTIIE GVNTPYLYFG MWKTTFAWHT EDMDLYSINY
210 220 230 240 250
LHFGEPKSWY AIPPEHGKRL ERLAIGFFPG SSQGCDAFLR HKMTLISPII
260 270 280 290 300
LKKYGIPFSR ITQEAGEFMI TFPYGYHAGF NHGFNCAEST NFATLRWIDY
310 320 330 340 350
GKVATQCTCR KDMVKISMDV FVRILQPERY ELWKQGKDLT VLDHTRPTAL
360 370 380 390 400
SSPELSTWSA SRASLKAKLL RRQISLKENR HWKKTEEERK PSLERKKEQT
410 420 430 440 450
RRPGLSSHRK RSQPKKPKPD DPRSPGEGAA GVALLEEAGG STKEEAAPEA
460 470 480 490 500
DPEEEEEEAQ LLPQGREAEG SEEDGRGKLR LAKAKSDRKK KSYGSLHPHH
510 520 530 540 550
PLLPPPPSSQ FTEEAPLLDI PGPAPGLEAA EESPLPPPLN VVPPKAPGEE
560 570 580 590 600
PEAKPRPVIP MLYVVPRPGP TGNKGRVSCQ QASEHFAQKG PTWKEQATPM
610 620 630 640 650
ELTGPEEESG ASEGQNPSTF SKLKMEIKKS RRHPLGRPPT RSPLSVVKQE
660 670 680 690 700
ASSDEESFPF SGDEDVGDPE ALRSLMSLQW KNKASNFQAE RKFNVAAALT
710 720 730 740 750
EPYCAICTLF YPYSQSLQTE KEAPQAALGE GSSAIPPSRS GQKTRPLIPE
760 770 780 790 800
MCFTASGENT EPLPANSYIG DDGTSPLIAC AKCCLQVHAS CYGIRPELVN
810 820 830 840 850
EGWTCSRCTA HAWTAECCLC NLRGGALQMT TDRRWVHVIC AIAVPEVRFL
860 870 880 890 900
NVMERHPVDI SGIPEQRWKL KCVYCRKRMK KVSGACIQCS CEHCSTSFHV
910 920 930 940 950
TCAHAAGVLM EPDDWPYVVS ITCFKHKSGG HSVQVMRAVS LGQVVITKNR
960 970 980 990 1000
NGLYYRCRVI GTTTQTFYEV NFDDGSYSDN LYPESITSRD CARLGPPPEG
1010 1020 1030 1040 1050
EFVELRWTDG NLYRAKFISS VTSHIYQVEF EDGSQLTVKR GDIFTLDEEL
1060 1070 1080 1090 1100
PKRVRSRLSV STGAPQESVF SGEEVKAAKR PRVGTPRAAE DSGRNPDYPA
1110
FMESLLQAQC WPGAPY
Length:1,116
Mass (Da):124,845
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4928D3FDFBEB2D8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1N3A5A0A3Q1N3A5_BOVIN
[Histone H3]-trimethyl-L-lysine(9) ...
KDM4B
1,082Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_002688966.2, XM_002688920.5
XP_010796608.1, XM_010798306.2
XP_010805297.1, XM_010806995.2
XP_015319623.1, XM_015464137.1
XP_015319624.1, XM_015464138.1
XP_584880.4, XM_584880.9

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000020586; ENSBTAP00000020586; ENSBTAG00000015487

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_002688966.2, XM_002688920.5
XP_010796608.1, XM_010798306.2
XP_010805297.1, XM_010806995.2
XP_015319623.1, XM_015464137.1
XP_015319624.1, XM_015464138.1
XP_584880.4, XM_584880.9

3D structure databases

SMRiE1BA41
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020586

Proteomic databases

PaxDbiE1BA41
PRIDEiE1BA41

Genome annotation databases

EnsembliENSBTAT00000020586; ENSBTAP00000020586; ENSBTAG00000015487

Organism-specific databases

VEuPathDBiHostDB:ENSBTAG00000015487
VGNCiVGNC:30528, KDM4B

Phylogenomic databases

eggNOGiKOG0958, Eukaryota
GeneTreeiENSGT00940000159248
HOGENOMiCLU_001442_0_0_1
InParanoidiE1BA41
OMAiTVECCLC
OrthoDBi1186832at2759
TreeFamiTF106449

Gene expression databases

BgeeiENSBTAG00000015487, Expressed in leukocyte and 96 other tissues
ExpressionAtlasiE1BA41, baseline

Family and domain databases

CDDicd04508, TUDOR, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732, EPHD
IPR003347, JmjC_dom
IPR003349, JmjN
IPR040477, KDM4_Tudor_2
IPR002999, Tudor
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR013083, Znf_RING/FYVE/PHD
IPR007527, Znf_SWIM
PfamiView protein in Pfam
PF02373, JmjC, 1 hit
PF02375, JmjN, 1 hit
PF18104, Tudor_2, 2 hits
SMARTiView protein in SMART
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SM00249, PHD, 2 hits
SM00333, TUDOR, 2 hits
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS50966, ZF_SWIM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BA41_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BA41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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