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Entry version 60 (02 Jun 2021)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Leucine rich repeats and IQ motif containing 1

Gene

LRRIQ1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine rich repeats and IQ motif containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRIQ1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:56221, LRRIQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1B933

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000027900, Expressed in testis and 32 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1B933, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000040019

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 52DisorderedSequence analysisAdd BLAST22
Regioni1160 – 1182DisorderedSequence analysisAdd BLAST23
Regioni1200 – 1244DisorderedSequence analysisAdd BLAST45
Regioni1452 – 1473DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili183 – 210Sequence analysisAdd BLAST28
Coiled coili215 – 235Sequence analysisAdd BLAST21
Coiled coili258 – 278Sequence analysisAdd BLAST21
Coiled coili318 – 365Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1161 – 1182Polar residuesSequence analysisAdd BLAST22
Compositional biasi1200 – 1220Polar residuesSequence analysisAdd BLAST21
Compositional biasi1221 – 1242Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1459 – 1473Basic and acidic residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0531, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002837_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1B933

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVPEPIP

Database of Orthologous Groups

More...
OrthoDBi
433355at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333460

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612, IQ, 2 hits
PF13855, LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 3 hits
PS51450, LRR, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E1B933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEGNDDDDI KLSEEIEAEL DRISISSLEK YGFDSDSKSE TQSDNSDTDS
60 70 80 90 100
DELPESVLHC INIIKNKSKT AEELILQDLE DTDVLSCGYG GVSNNHMHLR
110 120 130 140 150
IELPTECKEN PEQLIKMLSE IEKEEFLRSR THCGSPDLVL ESDLCDLPVD
160 170 180 190 200
EHVLPDDADI NFGYREVEER CRQSFEAWQD KQKELEDQEK ETLKVERDKE
210 220 230 240 250
EKQFQEEEEK RHCWMKQFEV EKKKLENIQK QEQDKMNDEL HKEEKIWKER
260 270 280 290 300
FKQHADFIRN LHLQMEEERT KFKDLQEKEK MRLSKLQHNA AVKIQAKYKA
310 320 330 340 350
FVAYQKYGPI IKEQIESKKK KAQEWKEKEA KIRQIEEKRK RLEEKQRIEE
360 370 380 390 400
EIEKQMQEGR KRREKEYMGK KNILRQEREQ LLKMEKLILR EATRKQLIIS
410 420 430 440 450
RALKKGEYNA KHLPIEDTSK NKDVGAKRLG DGKLKMWEDA SPWLAEESDK
460 470 480 490 500
RKNVDRELVL KESVQVQLKE SMSSQAILAV FKVEEKKKNL AVQCSEEFVK
510 520 530 540 550
QKRNYENRDQ KNQLENLHLK EDVREQFQSQ ELQSQVQKEE VLKPSINETM
560 570 580 590 600
RQETQIILGN NQEIDEVKDN ESQKIVDDNQ QNKMQKVEKE ISGQLGTLYE
610 620 630 640 650
ENNIKEISVI SMKQKQVPLK LEKSEHIGEN TLLQEEEIDL KSKEAEENPN
660 670 680 690 700
GSALNSDLVF NTNDAVINVE GKINKQNYIV DAPCEDLGGY NAKNCLVFKE
710 720 730 740 750
VNSLKSQIQE IPEECHENTA ECENIVACSI EPTLLSSIEE KRLAWITSFK
760 770 780 790 800
PWFEIFKQNQ QKKIVKRRRI IKCPVNTMPP LNPLEILRCG PWDTLQQVAT
810 820 830 840 850
ITFQDLPGCS LSTLAECPNL QFLSLRRCGL TSLHSLSNCK RLKYIDAQEN
860 870 880 890 900
HIETINCENL ENLCIVLLNK NQLTSLHGLD GCTNIQSLEL SHNKITRIGG
910 920 930 940 950
LESLKNLQQL IVDHNQLIST TGLCDTPTLM YLDCSHNHLT EVEGIEQCGL
960 970 980 990 1000
LQILKLQGNY LSELPFLGNH VLLRELHLDD NSISTVETFS SYWLPLLQIL
1010 1020 1030 1040 1050
TISQNSLTKI APLFHFVSLE KLDVSNNCLS DLTSAIKWFD ACFSLHELSL
1060 1070 1080 1090 1100
TGNPLLQEIN WRHSLLKILP ALRILNGEML TSCTERHTEG HHQLELEHFL
1110 1120 1130 1140 1150
EHCQSQIREF NLLSEKYITG DRNIFTLDVA QNLCYYFKKL MTLSNECRCV
1160 1170 1180 1190 1200
HEHGDVSMTR RGESEAQQNH LPPTHSDSKQ QNRVLYSSAN EYKLNSPDIS
1210 1220 1230 1240 1250
EKWMDSGSSH SSSTNPSLCE DTKERNQEEI VDQKREDSKT SSFPSKRIPF
1260 1270 1280 1290 1300
IETVRTRFLL ENCQNTEHHE KIMAAMVIQA YWRGYIVRRQ IHFSAKLHPA
1310 1320 1330 1340 1350
TIGPLTSKPN SCIENQTILK KEKVKNTVNI QEQKEKAAIL IQAVWKGFLL
1360 1370 1380 1390 1400
RKKLTTALEA IKNEESEEEY EEIDLEDFTF DEAALEKEWL ALDSARFPSQ
1410 1420 1430 1440 1450
TLLLPNQLHW PKFSGILKYD DTSLNLPSHP AQAWLCNEKE NVLSSEHTQF
1460 1470 1480 1490 1500
NSRSENRTLS RLPEAKTSRK SLLKSEKEEK ISEEWGFKDI STAQQMLKRA
1510 1520 1530 1540 1550
QKMKSKKLRK KLDPTVRLAL FRNNENKVSV IKPPEKAQPQ RDGFFEDKEE
1560 1570 1580 1590 1600
EFMYKDTTAN EKLERSKEYT YQWLHTQVGV LETTGSRNMK CKHFLPELDP
1610 1620 1630 1640 1650
DVRNGGRVQL VARLVSREDT DLDLFSMTSG SALSVKTEKK TLAHRHSAGS
1660
SSKLWFPSEL ISKSQMN
Length:1,667
Mass (Da):193,498
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF54A37E89B616007
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LP39A0A3Q1LP39_BOVIN
Leucine rich repeats and IQ motif c...
LRRIQ1
1,602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LQ05A0A3Q1LQ05_BOVIN
Leucine rich repeats and IQ motif c...
LRRIQ1
1,657Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M3F2A0A3Q1M3F2_BOVIN
Leucine rich repeats and IQ motif c...
LRRIQ1
1,617Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000040242; ENSBTAP00000040019; ENSBTAG00000027900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040019

Proteomic databases

PaxDbiE1B933

Genome annotation databases

EnsembliENSBTAT00000040242; ENSBTAP00000040019; ENSBTAG00000027900

Organism-specific databases

VGNCiVGNC:56221, LRRIQ1

Phylogenomic databases

eggNOGiKOG0531, Eukaryota
GeneTreeiENSGT00940000162858
HOGENOMiCLU_002837_0_0_1
InParanoidiE1B933
OMAiFVPEPIP
OrthoDBi433355at2759
TreeFamiTF333460

Gene expression databases

BgeeiENSBTAG00000027900, Expressed in testis and 32 other tissues
ExpressionAtlasiE1B933, baseline

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00612, IQ, 2 hits
PF13855, LRR_8, 1 hit
SMARTiView protein in SMART
SM00015, IQ, 3 hits
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 3 hits
PS51450, LRR, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1B933_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1B933
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 60 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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