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UniProtKB - E1AZ71 (E1AZ71_MOUSE)
Protein
Submitted name:
Cyclic nucleotide-gated channel beta 1
Gene
Cngb1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cGMP binding Source: MGI
- cyclic nucleotide-gated ion channel activity Source: MGI
- intracellular cAMP-activated cation channel activity Source: GO_Central
- intracellular cGMP-activated cation channel activity Source: MGI
GO - Biological processi
- cation transport Source: MGI
- detection of chemical stimulus involved in sensory perception of smell Source: ARUK-UCL
- detection of light stimulus involved in visual perception Source: MGI
- ion channel modulating, G protein-coupled receptor signaling pathway Source: ARUK-UCL
- membrane depolarization Source: ARUK-UCL
- olfactory nerve maturation Source: ARUK-UCL
- photoreceptor cell maintenance Source: MGI
- photoreceptor cell outer segment organization Source: MGI
- phototransduction Source: MGI
- positive regulation of gene expression Source: ARUK-UCL
- protein localization to organelle Source: MGI
- response to odorant Source: ARUK-UCL
- retina homeostasis Source: MGI
- sensory perception of smell Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-2485179, Activation of the phototransduction cascade R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-5620916, VxPx cargo-targeting to cilium |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclic nucleotide-gated channel beta 1Submitted name: cGMP-gated cation channel beta subunitImported |
Gene namesi | Name:Cngb1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2664102, Cngb1 |
VEuPathDBi | HostDB:ENSMUSG00000031789 |
Subcellular locationi
Other locations
- membrane Source: MGI
- photoreceptor outer segment Source: MGI
- transmembrane transporter complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 727 – 745 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 765 – 785 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000031789, Expressed in retinal neural layer and 116 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1038 – 1142 | Cyclic nucleotide-bindingInterPro annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 124 | DisorderedSequence analysisAdd BLAST | 124 | |
Regioni | 147 – 198 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 227 – 279 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 340 – 470 | DisorderedSequence analysisAdd BLAST | 131 | |
Regioni | 482 – 637 | DisorderedSequence analysisAdd BLAST | 156 | |
Regioni | 659 – 694 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1226 – 1325 | DisorderedSequence analysisAdd BLAST | 100 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1205 – 1225 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 31 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 45 – 77 | Acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 108 – 124 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 235 – 260 | Pro residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 356 – 379 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 380 – 395 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 396 – 419 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 420 – 465 | Acidic residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 500 – 519 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 557 – 574 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 589 – 603 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 612 – 637 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 659 – 679 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1226 – 1241 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1250 – 1276 | Pro residuesSequence analysisAdd BLAST | 27 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG0499, Eukaryota |
GeneTreei | ENSGT00940000154824 |
HOGENOMi | CLU_005746_11_0_1 |
OrthoDBi | 1073751at2759 |
TreeFami | TF318250 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR032944, CNGB1 IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR014710, RmlC-like_jellyroll |
PANTHERi | PTHR45638:SF16, PTHR45638:SF16, 2 hits |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS00889, CNMP_BINDING_2, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
E1AZ71-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGWVQRVLP QPPGTPQKTV ETAGPQPETE SKPEANPQPE PEPQQEPEPE
60 70 80 90 100
PEPEPEPEPE PEPEPEPEPE PEPEPVPEEA PPEVQALPPE EPMEGEGEAE
110 120 130 140 150
AGPSLQETQV ADPAQPTSQA QVAVAKVNRP SSWMLSWFWR GMQKVVPQPV
160 170 180 190 200
CSNGGQNLAA GERDPDQGGA QIPEPCGTGD PGSAEASGTQ DTEPSLWLLR
210 220 230 240 250
WLEQNLEKVL PQPPPPSLAW KVEPEAAVLD PDPPGTPMQM EPTESPSQPN
260 270 280 290 300
PGPLEPEEEP AAEPQPGFQS SSLPPPGDPV RLIEWLLHRL EMALPQPVLH
310 320 330 340 350
GKAAEQEPGC PGMCDVQTIS ILPVEQVEHD LVLEEVDSCW EDAQQEDGAS
360 370 380 390 400
PQETEVAPAH EEESEAIVEI PRELTKIQEE REDEQEEDEE EKEEEKKKGE
410 420 430 440 450
EEKEKEEEEK EKEKEKEEEK EEEEKEEEEE EEKEEEEEEK EEEEKEEEEK
460 470 480 490 500
EEEEEEEEEE EEPIVLLDSC LVVQADVDEC QLERTPSELA SIQELPEEKE
510 520 530 540 550
EKEEEKEEEK EEEEEKKEEE VEKKEEGEAT NSTVPATKEH PELQVEDTDA
560 570 580 590 600
DSGPLIPEET LPPPERPPPS PVKSDTLTVP GAAAAGHRKK LPSQDDEAEE
610 620 630 640 650
LKALSPAESP VVAWSDPTTP QEADGQDRAA STASQNSAII NDRLQELVKM
660 670 680 690 700
FKERTEKVKE KLIDPDVTSD EESPKPSPAK KAPEPDPAQK PAEAEVAEEE
710 720 730 740 750
HYCDMLCCKF KRRPLKMYRF PQSIDPLTNL MYILWLFFVV LAWNWNCWLI
760 770 780 790 800
PVRWAFPYQR ADNIHFWLLM DYLCDFIYLL DITVFQMRLQ FVKGGDIITD
810 820 830 840 850
KKEMRNNYLK SRRFKMDLLC LLPLDFLYLK LGINPLLRLP RCLKYMAFFE
860 870 880 890 900
FNNRLEAILS KAYVYRVIRT TAYLLYSLHL NSCLYYWASA FQGIGSTHWV
910 920 930 940 950
YDGVGNSYIR CYYWAVKTLI TIGGLPDPQT LFEIVFQLLN YFTGVFAFSV
960 970 980 990 1000
MIGQMRDVVG AATAGQTYYR SCMDSTVKYM NFYKIPRSVQ NRVKTWYEYT
1010 1020 1030 1040 1050
WHSQGMLDES ELMVQLPDKM RLDLAIDVNY SIVSKVALFQ GCDRQMIFDM
1060 1070 1080 1090 1100
LKRLRSVVYL PNDYVCKKGE IGREMYIIQA GQVQVLGGPD GKAVLVTLKA
1110 1120 1130 1140 1150
GSVFGEISLL AVGGGNRRTA NVVAHGFTNL FILDKKDLNE ILVHYPESQK
1160 1170 1180 1190 1200
LLRKKARRML RNNNKPKEEK SVLILPPRAG TPKLFNAALA AAGKMGPRGA
1210 1220 1230 1240 1250
KGGKLAHLRA RLKELAALEA AARQQQLLEQ AKSSQEAGGE EGSGATDQPA
1260 1270 1280 1290 1300
PQEPPEPKDP PKPPGPPEPS AQSSPPPASA KPEESTGEAA GPPEPSVRIR
1310 1320
VSPGPDPGEQ TLSVEVLEEK KEGAE
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PXX0 | E9PXX0_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 | 866 | Annotation score: | ||
Q91WA8 | Q91WA8_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 BC016201 | 326 | Annotation score: | ||
A0A1D5RLA7 | A0A1D5RLA7_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 | 227 | Annotation score: | ||
A0A1D5RLH2 | A0A1D5RLH2_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 | 207 | Annotation score: | ||
A0A1D5RLJ2 | A0A1D5RLJ2_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 | 228 | Annotation score: | ||
A0A1D5RLZ4 | A0A1D5RLZ4_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 | 193 | Annotation score: | ||
V9GXN8 | V9GXN8_MOUSE | Cyclic nucleotide-gated channel bet... | Cngb1 | 32 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ116386 mRNA Translation: ADM45272.1 |
RefSeqi | NP_001182342.1, NM_001195413.1 |
Genome annotation databases
Ensembli | ENSMUST00000119870.9; ENSMUSP00000113827.3; ENSMUSG00000031789.18 |
GeneIDi | 333329 |
KEGGi | mmu:333329 |
UCSCi | uc009myb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ116386 mRNA Translation: ADM45272.1 |
RefSeqi | NP_001182342.1, NM_001195413.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 341490 |
Protocols and materials databases
Antibodypediai | 48567, 120 antibodies from 21 providers |
DNASUi | 333329 |
Genome annotation databases
Ensembli | ENSMUST00000119870.9; ENSMUSP00000113827.3; ENSMUSG00000031789.18 |
GeneIDi | 333329 |
KEGGi | mmu:333329 |
UCSCi | uc009myb.2, mouse |
Organism-specific databases
CTDi | 1258 |
MGIi | MGI:2664102, Cngb1 |
VEuPathDBi | HostDB:ENSMUSG00000031789 |
Phylogenomic databases
eggNOGi | KOG0499, Eukaryota |
GeneTreei | ENSGT00940000154824 |
HOGENOMi | CLU_005746_11_0_1 |
OrthoDBi | 1073751at2759 |
TreeFami | TF318250 |
Enzyme and pathway databases
Reactomei | R-MMU-2485179, Activation of the phototransduction cascade R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-5620916, VxPx cargo-targeting to cilium |
Miscellaneous databases
BioGRID-ORCSi | 333329, 5 hits in 74 CRISPR screens |
ChiTaRSi | Cngb1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031789, Expressed in retinal neural layer and 116 other tissues |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR032944, CNGB1 IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR014710, RmlC-like_jellyroll |
PANTHERi | PTHR45638:SF16, PTHR45638:SF16, 2 hits |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS00889, CNMP_BINDING_2, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E1AZ71_MOUSE | |
Accessioni | E1AZ71Primary (citable) accession number: E1AZ71 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 2, 2010 |
Last sequence update: | November 2, 2010 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |