UniProtKB - E1ANH6 (BLC97_ECOLX)
Protein
Beta-lactamase CTX-M-97
Gene
bla
Organism
Escherichia coli
Status
Functioni
Is probably capable of hydrolyzing cephalosporins such as ceftriaxone and ceftazidime, thus conferring resistance to these antibiotics.
Catalytic activityi
- EC:3.5.2.6PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | Acyl-ester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- beta-lactamase activity Source: UniProtKB-EC
GO - Biological processi
- beta-lactam antibiotic catabolic process Source: InterPro
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Antibiotic resistance |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:bla |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000420868 | 29 – 291 | Beta-lactamase CTX-M-97Add BLAST | 263 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | E1ANH6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 237 – 239 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the class-A beta-lactamase family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR000871, Beta-lactam_class-A IPR023650, Beta-lactam_class-A_AS |
PRINTSi | PR00118, BLACTAMASEA |
SUPFAMi | SSF56601, SSF56601, 1 hit |
PROSITEi | View protein in PROSITE PS00146, BETA_LACTAMASE_A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
E1ANH6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTQSIGRSM LTVMATLPLL FSSATLHAQA NSVQQQLEAL EKSSGGRLGV
60 70 80 90 100
ALINTADNSQ ILYRADERFA MCSTSKVMAA AAVLKQSESD KHLLNQRVEI
110 120 130 140 150
KKSDLVNYNP IAEKHVNGTM TLAELGAAAL QYSDNTAMNK LIAHLGGPDK
160 170 180 190 200
VTAFARSLGD ETFRLDRTEP TLNTAIPGDP RDTTTPLAMA QTLKNLTLGK
210 220 230 240 250
ALAETQRAQL VTWLKGNTTG SASIRAGLPK SWVVGDKTGS GDYGTTNDIA
260 270 280 290
VIWPENHAPL VLVTYFTQPE QKAESRRDIL AAAAKIVTHG F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM776707 Genomic DNA Translation: ADM08178.1 |
RefSeqi | WP_063860093.1, NG_049051.1 |
Genome annotation databases
KEGGi | ag:ADM08178 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM776707 Genomic DNA Translation: ADM08178.1 |
RefSeqi | WP_063860093.1, NG_049051.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5A90 | neutron diffraction | 1.70 | A | 30-291 | [»] | |
5A91 | X-ray | 1.20 | A | 30-291 | [»] | |
5A92 | X-ray | 1.05 | A | 30-291 | [»] | |
5A93 | Other | 1.60 | A | 30-291 | [»] | |
5G18 | X-ray | 1.10 | A | 30-291 | [»] | |
SMRi | E1ANH6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
KEGGi | ag:ADM08178 |
Family and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR000871, Beta-lactam_class-A IPR023650, Beta-lactam_class-A_AS |
PRINTSi | PR00118, BLACTAMASEA |
SUPFAMi | SSF56601, SSF56601, 1 hit |
PROSITEi | View protein in PROSITE PS00146, BETA_LACTAMASE_A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BLC97_ECOLX | |
Accessioni | E1ANH6Primary (citable) accession number: E1ANH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2013 |
Last sequence update: | November 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families