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Protein

L-lactate dehydrogenase

Gene

8232374

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (8232374)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105SubstrateUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:8232374Imported
ORF Names:Phum_PHUM581610Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
Proteomesi
  • UP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi121225.PHUM581610-PA

Structurei

3D structure databases

ProteinModelPortaliE0W1P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 159Ldh_1_NInterPro annotationAdd BLAST139
Domaini162 – 329Ldh_1_CInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

InParanoidiE0W1P5
KOiK00016
OMAiMDLMQTA
PhylomeDBiE0W1P5

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

E0W1P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTQKLLLNP VSKIKSTSNN KITIVGAGQV GLACAYSILT QNVSSHICLI
60 70 80 90 100
DMIEDKVKGE VLDLQHGTTF LRGAKIEGGT DYQLSAGSKI CIVTAGARQK
110 120 130 140 150
DGESRLNLVQ RNTNIFKEII PKLVEHSPDT ILLIVSNPVD ILTFVAWKLS
160 170 180 190 200
GLPQHRVIGS GTNLDTSRFR VLLSERLGIS PTSCHGWIVG EHGDTSVAVW
210 220 230 240 250
SGVNVAGVRL QDLNSTIGTS EDLENWEETH EQVVRSAYEI IKLKGYTSWA
260 270 280 290 300
IGLSLSSISM SILLNTQNVH AVSTNLKGYY GIEDEIFLSL PCVLGSEGIT
310 320 330
HVVSLPLNKK ETSLLIKSAK TLKEIQENIK M
Length:331
Mass (Da):36,045
Last modified:November 2, 2010 - v1
Checksum:i75C79FE423D6FBF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235873 Genomic DNA Translation: EEB19627.1
RefSeqiXP_002432365.1, XM_002432320.1

Genome annotation databases

EnsemblMetazoaiPHUM581610-RA; PHUM581610-PA; PHUM581610
GeneIDi8232374
KEGGiphu:Phum_PHUM581610
VectorBaseiPHUM581610-RA; PHUM581610-PA; PHUM581610

Similar proteinsi

Entry informationi

Entry nameiE0W1P5_PEDHC
AccessioniPrimary (citable) accession number: E0W1P5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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