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Protein

General transcription factor IIH subunit 4

Gene

8233263

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
Name:8233263Imported
ORF Names:Phum_PHUM518520Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
Proteomesi
  • UP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi121225.PHUM518520-PA

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

InParanoidiE0VYT4
KOiK03144
OMAiYLEQYAH
PhylomeDBiE0VYT4

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

E0VYT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESSRGHRS HIQVKNLRCK YLHEYLQTLP LATLEQLYNH PTTCLAVFRE
60 70 80 90 100
LPQIARHYVS RLLFVEQPVP QAVIASWISQ THSKEHLTAT KVLTDLRVWQ
110 120 130 140 150
EAAIPGGLPG WILNSVFKKN MKISLLGGGR PWTMSAQLEP DTKPRDIPYL
160 170 180 190 200
DNYAMERWEC VLHYMVGSQA QEGISADAVR ILLHANLMKR DEEDGSCVIT
210 220 230 240 250
REGFQFLLLD TASQVWYFML QYLDTVSARN LDLVECLTFL FQLSFSTLGK
260 270 280 290 300
DYSTIGMSEG LLVFLQHLRE FGLIYQRKRR GGRFYPTRLA LNIACGENKS
310 320 330 340 350
LQQMNKEGYI IIETNYRVYA YTDSNLQVAL LGLFCEMLYR FPNLSVGLIT
360 370 380 390 400
RDSVRQAFKS GITAEQIVGF LRLHAHPRMI AVGPPTLPPT VVDQIKLWEN
410 420 430 440 450
ELNRLVYSDG VLYSQFLSQA DFEALRDRAN ELGVLVWEND KKRTMVVTKS
460
GHDDVKKFWK SYSKANS
Length:467
Mass (Da):53,511
Last modified:November 2, 2010 - v1
Checksum:i56D75EA162B9942E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235847 Genomic DNA Translation: EEB18540.1
RefSeqiXP_002431278.1, XM_002431233.1

Genome annotation databases

EnsemblMetazoaiPHUM518520-RA; PHUM518520-PA; PHUM518520
GeneIDi8233263
KEGGiphu:Phum_PHUM518520
VectorBaseiPHUM518520-RA; PHUM518520-PA; PHUM518520

Similar proteinsi

Entry informationi

Entry nameiE0VYT4_PEDHC
AccessioniPrimary (citable) accession number: E0VYT4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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