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Entry version 58 (05 Dec 2018)
Sequence version 1 (02 Nov 2010)
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Protein
Submitted name:

Dicer-1, putative

Gene

8230564

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, RNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dicer-1, putativeImported (EC:3.1.26.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:8230564Imported
ORF Names:Phum_PHUM435060Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPediculus humanus subsp. corporis (Body louse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri121224 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009046 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
121225.PHUM435060-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 197Helicase ATP-bindingInterPro annotationAdd BLAST175
Domaini581 – 750Helicase C-terminalInterPro annotationAdd BLAST170
Domaini778 – 873Dicer dsRNA-binding foldInterPro annotationAdd BLAST96
Domaini1053 – 1200PAZInterPro annotationAdd BLAST148
Domaini1616 – 1834RNase IIIInterPro annotationAdd BLAST219
Domaini1914 – 2071RNase IIIInterPro annotationAdd BLAST158
Domaini2105 – 2162DRBMInterPro annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili464 – 487Sequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E0VTQ0

KEGG Orthology (KO)

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KOi
K11592

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSDNWLP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E0VTQ0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E0VTQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHLIDNVH SKSLTPKEPN VELLDASCVR NIIVCLGNNI GKTFIASKLI
60 70 80 90 100
QNTSNNISVN NGTITLYVAD SSVVVSRKAA YFQRLTNMLV AEYHKGNCNK
110 120 130 140 150
IKKIKKIPKL DQIVVAETET ANYMLENELI VMSDINLLIL HDCHCVLKNG
160 170 180 190 200
IVPQKELMKF YYNSSTKPHI LSLASSLFSS NLDLSQIKSC LNKMEDILNC
210 220 230 240 250
KAETASNVLS LLRYGTHPHE VLIEYGLHIP SSIDEIIEGE ILKAIQFIKD
260 270 280 290 300
HRYDPLEMYE SFTEELQDIP DPKKEPEEIF LELLNVLHTL GPWSTDRAAL
310 320 330 340 350
VLLLQIEKLK VTTPYERHFL LLCMASTVLV KIRAILDDFF KDIDEKERIY
360 370 380 390 400
KYSSPKILRV IEILRKFVPE KLDVKLDDNL SVKNQSNKLS DASKTISKAI
410 420 430 440 450
ETSAEKCSTI LNESEMKKQC LNCDCTIMTE YLLKRLDSSD IKNFTYDNFA
460 470 480 490 500
KLEKEGYSNF IMNNEDLSKS ATQIENNERN LKELGDKNEI SLLSNNFSNN
510 520 530 540 550
CNESLNQSNN NKPIKNFFYE NNNKSKKEHS NSILRNKNGF LPIAKENILR
560 570 580 590 600
AVNESLQMKK RKINETHTIE RENQDDFIFK QLKNFGDSDV PLCGLIFVEK
610 620 630 640 650
KFTAKVLFHV LNDLKQADED FSFLNVQFTV GKVVDGTKDP KGAENEHRKQ
660 670 680 690 700
ELMLKRFRIR ACNLLIGTSF LEEGIELPKC NLVIRFDVPK HYRSYINTKE
710 720 730 740 750
RARAANSLFC LLVGPNEKDD FVHELAKYYE TEAVLLEKCG HLEPEEEEEN
760 770 780 790 800
EADLYTQLVQ PFCPLLKREC PHVDLSSAVM LLNRYCAKLP SDTFTRLTPI
810 820 830 840 850
CNIKTVKEFE RKMYVCTIRL PINSPIKQEI EGCPMPTRVL AKRFAAFQCC
860 870 880 890 900
QLLHLSGELD DTLQPISKES FWIREEGRLT VTNDETEEIV SRDSLEPRPG
910 920 930 940 950
TTKRRQYYYK KIADSLTDCL PMADKPSFLY DISMVLSCPL PEEQNTRGRK
960 970 980 990 1000
IHPPENSSQG FGILTKKRIP KIGPFPIFTR SGEVQVKLKL AQTTVQLTEI
1010 1020 1030 1040 1050
EINKIVAFIH YTFTSVLRLQ KYLMMFDPNS SENSYFIVPT KKVKDSDSVE
1060 1070 1080 1090 1100
VDWAFLELIY EKRNQVPTFI PEENRKNFVF EPSKFEDAVV SPWYRNQDQP
1110 1120 1130 1140 1150
QYLYVAEICT NLNPKSAFPG TEYQTFEEYY LKKYNIVIQN LDQALLDVDH
1160 1170 1180 1190 1200
TSARLNFLTP RYVNRKGVAL PTTSEEKKRA KRENLKQKQI LIPELCDIHP
1210 1220 1230 1240 1250
FPATLWRKAV CLPCILHRIN ALLLADQVRM IVAEEIGVGS IDLNEEFNGN
1260 1270 1280 1290 1300
PFNLGWSWAD VLKQTKILKK QREETPEAVK SIEMKDESDH VNKNNKDTQN
1310 1320 1330 1340 1350
CNDNDRENDS DLKVTLNDSC NTEIVLEESN ESDKDDKQWV EIGTWSNDMA
1360 1370 1380 1390 1400
DDKLENIYDD SHDPDEIDDL RLPKNLTMIE ETDGKEINDW DSKIFSEMKD
1410 1420 1430 1440 1450
SVRYCSPTSW LGEPKMDDEV LDGLSESTYS DDYFDGYMNS DTDSECGGLK
1460 1470 1480 1490 1500
IEFKDDNVAE AVENNHTATN FIKELNEVEE SEPWYYDESE KYSKYVDEFY
1510 1520 1530 1540 1550
ANVQNRKEKI INSDMYYSEE KSFDFSRSHS KNYQKTYPGC CKNDSQSETS
1560 1570 1580 1590 1600
ENFGSADNRL PRLNENLQND FKSLPYFKII SEVLKREENK QANPKNNVLG
1610 1620 1630 1640 1650
FELKTLPSNY KPFEEIDEIC QKFSFDEQPD LSGHPGPSPS LILQALTMSN
1660 1670 1680 1690 1700
ANDGINLERL ETIGDSFLKY AITTYLYCIY ENVHEGKLSH LRSKQVSNFN
1710 1720 1730 1740 1750
LYRLGRKKML GESMVATKFE PHDNWLPPCY YVPRELERAL IEAGVPASHW
1760 1770 1780 1790 1800
NRADLPSLKN LSKEEICQLV KEKGEKLGIV NAEKKPINVT IPCLNLENMP
1810 1820 1830 1840 1850
CFIPYNLMTQ HSIPDKSIAD CVEALIGAYL VACGPRGALL FMSWLGIKVL
1860 1870 1880 1890 1900
PKEEKFFESE NDPDIKKGVG ASRPIKVMTN NGEVTFGKLK SPKRPLICHI
1910 1920 1930 1940 1950
PNPEGELEKL LRGFDIFEES IKYRFRDRSY LLQALTHASY YPNRLTDCYQ
1960 1970 1980 1990 2000
RLEFLGDAVL DYLITRHLYE DSRHHSPGAL TDLRSALVNN TIFASLAVRH
2010 2020 2030 2040 2050
DFHKYFRHLC PSLNEVVDRF VRFQQANGHA ISEEFYLIEE EECEEAEDVE
2060 2070 2080 2090 2100
VPKALGDVFE SVAGAIFLDS GMSLDAVWRV YYRIMKNEIE LFSTNVPKSP
2110 2120 2130 2140 2150
IRELFELEPE TAQFGKPEKL ADGRRVRVSV EVFGKGIFNG IGRNYRIAKC
2160 2170
TAAKCALKQL KRKGLLELFF TNVGYMKSF
Length:2,179
Mass (Da):250,578
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4526A841D62A82E3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS235769 Genomic DNA Translation: EEB16756.1

NCBI Reference Sequences

More...
RefSeqi
XP_002429494.1, XM_002429449.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
PHUM435060-RA; PHUM435060-PA; PHUM435060

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8230564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
phu:Phum_PHUM435060

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
PHUM435060-RA; PHUM435060-PA; PHUM435060

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235769 Genomic DNA Translation: EEB16756.1
RefSeqiXP_002429494.1, XM_002429449.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi121225.PHUM435060-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM435060-RA; PHUM435060-PA; PHUM435060
GeneIDi8230564
KEGGiphu:Phum_PHUM435060
VectorBaseiPHUM435060-RA; PHUM435060-PA; PHUM435060

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8230564

Phylogenomic databases

InParanoidiE0VTQ0
KOiK11592
OMAiPSDNWLP
PhylomeDBiE0VTQ0

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE0VTQ0_PEDHC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E0VTQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: December 5, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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