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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

8229823

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotationSAAS annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei103S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei106UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:8229823Imported
ORF Names:Phum_PHUM300660Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
Proteomesi
  • UP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi121225.PHUM300660-PA

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 51S-adenosyl-L-methionine bindingUniRule annotation2
Regioni83 – 84S-adenosyl-L-methionine bindingUniRule annotation2
Regioni181 – 183S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotationSAAS annotation

Phylogenomic databases

InParanoidiE0VM45
KOiK03439
OMAiIGMEIRV
PhylomeDBiE0VM45

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

E0VM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWSDLYPSF FGNESLTNKE VQFADIGCGY GGLLVTLSPL FPDVLMLGME
60 70 80 90 100
IRVKVSDYVI SKIAALRSQY PGKYENIACV RSNAMKYLPN YFKKGQLTKM
110 120 130 140 150
FFLYPDPHFK KSKHRWRIIN DSLLAEYAYV LKEGGVVYTV TDVLDLHEWM
160 170 180 190 200
VKHFDNHPLF VALTREEIDN DPVIDKLYQS SEEGQKVTRN NGEKFLAVYR
210
RISDPYLMNE NKMKL
Length:215
Mass (Da):25,002
Last modified:November 2, 2010 - v1
Checksum:iEBDBB8D702DF02AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235289 Genomic DNA Translation: EEB14451.1
RefSeqiXP_002427189.1, XM_002427144.1

Genome annotation databases

EnsemblMetazoaiPHUM300660-RA; PHUM300660-PA; PHUM300660
GeneIDi8229823
KEGGiphu:Phum_PHUM300660
VectorBaseiPHUM300660-RA; PHUM300660-PA; PHUM300660

Similar proteinsi

Entry informationi

Entry nameiE0VM45_PEDHC
AccessioniPrimary (citable) accession number: E0VM45
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 31, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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