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Entry version 76 (10 Feb 2021)
Sequence version 1 (02 Nov 2010)
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Protein

E3 ubiquitin-protein ligase parkin

Gene

8230172

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi151Zinc 1Combined sources1
Metal bindingi155Zinc 1Combined sources1
Metal bindingi167Zinc 2Combined sources1
Metal bindingi170Zinc 2Combined sources1
Metal bindingi197Zinc 2Combined sources1
Metal bindingi202Zinc 2Combined sources1
Metal bindingi213Zinc 1Combined sources1
Metal bindingi216Zinc 1; via pros nitrogenCombined sources1
Metal bindingi240Zinc 3Combined sources1
Metal bindingi243Zinc 3Combined sources1
Metal bindingi255Zinc 4Combined sources1
Metal bindingi259Zinc 4; via pros nitrogenCombined sources1
Metal bindingi262Zinc 3Combined sources1
Metal bindingi265Zinc 3Combined sources1
Metal bindingi291Zinc 4Combined sources1
Metal bindingi295Zinc 4Combined sources1
Metal bindingi334Zinc 5Combined sources1
Metal bindingi339Zinc 5Combined sources1
Metal bindingi354Zinc 5Combined sources1
Metal bindingi356Zinc 5Combined sources1
Metal bindingi361Zinc 6Combined sources1
Metal bindingi364Zinc 6Combined sources1
Metal bindingi369Zinc 6; via tele nitrogenCombined sources1
Metal bindingi373Zinc 6Combined sources1
Metal bindingi415Zinc 7Combined sources1
Metal bindingi418Zinc 7Combined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei428UniRule annotation1
Metal bindingi433Zinc 7Combined sources1
Metal bindingi438Zinc 7Combined sources1
Metal bindingi443Zinc 8Combined sources1
Metal bindingi446Zinc 8Combined sources1
Metal bindingi454Zinc 8Combined sources1
Metal bindingi458Zinc 8; via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processUbl conjugation pathwayUniRule annotationARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase parkinUniRule annotation (EC:2.3.2.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:8230172Imported
ORF Names:Phum_PHUM233570Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPediculus humanus subsp. corporis (Body louse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri121224 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009046 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:PHUM233570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6.

UniRule annotation

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61596N

STRING: functional protein association networks

More...
STRINGi
121225.PHUM233570-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 90Ubiquitin-likeInterPro annotationAdd BLAST61
Domaini236 – 461RING-typeInterPro annotationAdd BLAST226

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili120 – 140Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RBR family. Parkin subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0006, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050804_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E0VIU9

Identification of Orthologs from Complete Genome Data

More...
OMAi
AEFYMKC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E0VIU9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002867, IBR_dom
IPR003977, Parkin
IPR041565, Parkin_Znf-RING
IPR044066, TRIAD_supradom
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
IPR041170, Znf-RING_14

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00240, ubiquitin, 1 hit
PF17976, zf-RING_12, 1 hit
PF17978, zf-RING_14, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037880, Parkin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01475, PARKIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00647, IBR, 2 hits
SM00213, UBQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51873, TRIAD, 1 hit
PS50053, UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E0VIU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSILEWFWNI LCGMAQYLTF SKNLTNDNLV NIYVKSNVGG TISVNLDPKS
60 70 80 90 100
DIKNVKELVA PKLGLEPDDV KIIFAGKELL DSTVIEVLDF FSDILHAVKV
110 120 130 140 150
NKKIKNVIPD KPLCETLEEL HQLNDQKNVE SIEESNLKNE GKNKAHFFIY
160 170 180 190 200
CANPCKKINT GKLRVCCSEC KHGAFTVDTD PQSWADVLDK NKITGVCNNV
210 220 230 240 250
GCEGLYAKFY FKCASHPSQG ENDTAVPLNL IKRNHKKIPC LACTDICDPV
260 270 280 290 300
LVFSCDNRHV TCLECFKNYC GSRLKDRQFL SHPDFGYTLP CPAGCSNSFI
310 320 330 340 350
EEVHHFRLLT DAQYEQYHRF ATEEFILQAG GVLCPQPGCG QGILIDQNCN
360 370 380 390 400
RVQCSCGYVF CGKCLEGFHL GECLNPTDVP FLSQNCDYPL DPEKLEKARW
410 420 430 440 450
DEASSTVIKV LTKPCPKCRT STERAGGCMH MICTRANCGF HWCWVCQGPW
460
ERDCMASHWF G
Length:461
Mass (Da):51,864
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB874A02614DC7C52
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAZO01002709 Genomic DNA No translation available.
DS235206 Genomic DNA Translation: EEB13305.1

NCBI Reference Sequences

More...
RefSeqi
XP_002426043.1, XM_002425998.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
PHUM233570-RA; PHUM233570-PA; PHUM233570

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8230172

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
phu:Phum_PHUM233570

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZO01002709 Genomic DNA No translation available.
DS235206 Genomic DNA Translation: EEB13305.1
RefSeqiXP_002426043.1, XM_002425998.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CAWX-ray2.62A/C141-461[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61596N
STRINGi121225.PHUM233570-PA

Genome annotation databases

EnsemblMetazoaiPHUM233570-RA; PHUM233570-PA; PHUM233570
GeneIDi8230172
KEGGiphu:Phum_PHUM233570

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8230172
VEuPathDBiVectorBase:PHUM233570

Phylogenomic databases

eggNOGiKOG0006, Eukaryota
HOGENOMiCLU_050804_0_0_1
InParanoidiE0VIU9
OMAiAEFYMKC
PhylomeDBiE0VIU9

Enzyme and pathway databases

UniPathwayiUPA00143

Family and domain databases

InterProiView protein in InterPro
IPR002867, IBR_dom
IPR003977, Parkin
IPR041565, Parkin_Znf-RING
IPR044066, TRIAD_supradom
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
IPR041170, Znf-RING_14
PfamiView protein in Pfam
PF00240, ubiquitin, 1 hit
PF17976, zf-RING_12, 1 hit
PF17978, zf-RING_14, 1 hit
PIRSFiPIRSF037880, Parkin, 1 hit
PRINTSiPR01475, PARKIN
SMARTiView protein in SMART
SM00647, IBR, 2 hits
SM00213, UBQ, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51873, TRIAD, 1 hit
PS50053, UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE0VIU9_PEDHC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E0VIU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 10, 2021
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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