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Entry version 63 (11 Dec 2019)
Sequence version 1 (02 Nov 2010)
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Protein
Submitted name:

Methionine-tRNA synthetase, putative

Gene

8238335

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Methionine-tRNA synthetase, putativeImported (EC:6.1.1.10Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:8238335Imported
ORF Names:Phum_PHUM118730Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPediculus humanus subsp. corporis (Body louse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri121224 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009046 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
121225.PHUM118730-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 199GST C-terminalInterPro annotationAdd BLAST131
Domaini766 – 822WHEP-TRSInterPro annotationAdd BLAST57
Domaini830 – 886WHEP-TRSInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni744 – 763DisorderedSequence analysisAdd BLAST20
Regioni812 – 861DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi812 – 831PolarSequence analysisAdd BLAST20
Compositional biasi832 – 854PolyampholyteSequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E0VDL2

KEGG Orthology (KO)

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KOi
K01874

Identification of Orthologs from Complete Genome Data

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OMAi
KHLMATE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E0VDL2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00814 MetRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.20, 1 hit
3.40.30.10, 1 hit
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009068 S15_NS1_RNA-bd
IPR036249 Thioredoxin-like_sf
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR000738 WHEP-TRS_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09334 tRNA-synt_1g, 1 hit
PF00458 WHEP-TRS, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01041 TRNASYNTHMET

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00991 WHEP-TRS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47060 SSF47060, 2 hits
SSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF57770 SSF57770, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00398 metG, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit
PS51185 WHEP_TRS_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E0VDL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLTNENNI NSLKIVISSK ITKKSIHVLT NSIEKLNLKS PKTIPQLVLD
60 70 80 90 100
SGVHIFSSNA SSKFLFPPSV EHNSCVNYYL DVEATVIQPL IATFSGKVSD
110 120 130 140 150
KNKKSFEEIL NQCNNDLISK KFLCGNEITV SDVSIWCALY PIFTDTKFND
160 170 180 190 200
ILLNKDSLKK WFEFIFKLPE VQESLKLCNI KQGLSSIENL ACVQKSTSVK
210 220 230 240 250
PGSSSSQKFS IPSTPEKTIK DNSLTVTNEE KKIAAAAWKE NLPVAGETNI
260 270 280 290 300
LITSALPYVN NVPHLGNIIG CVLSGDVFAR FCRLRGYNTL YISGTDEYGT
310 320 330 340 350
ATETKALEEG LTPREICDKY YKIHDAIYKW FGISFDYFGR TTTPQQTEIC
360 370 380 390 400
QLIFKKINEN NYIISDVVEQ LLCEKCDRYL ADRFVEGVCP RCSYEDARGD
410 420 430 440 450
QCDGCGHLIN APELIKPRCK MCKQTPVLRQ SKQFFLDLPK IEPLLKEWIQ
460 470 480 490 500
QRWLDWSHNA REISKAWLND GLKPRCITRD LKWGIPVPLE GFESKVFYVW
510 520 530 540 550
FDAPIGYISI TKGYTSEWKK WWMPDKNTKV NLYQFMAKDN VPFHSVMFPA
560 570 580 590 600
SLIASKENYV TVSNIFATEY LNYEDGKFSK SRGIGVFGND AQETGIPADV
610 620 630 640 650
WRFYLLYVRP ESQDSSFSWS DLALKNNSEL LSVLGNFINR ALMFCEKTFD
660 670 680 690 700
SKIPNMNLTD ENYELVALVN RELHEYISVI EKGKLREGIR HLLSIARLGN
710 720 730 740 750
QFMQSSQPWV LCKGSEDDKK PFPLFNKIED DLINKLKAKY AGVQSANSHG
760 770 780 790 800
KGGDDGKKTG GHIGNDVSSL EAAVVAQGDV VRKMKAAGKT KAEWGPEVTI
810 820 830 840 850
LLDLKKKLAE AQANNQNNSA TNPVTPNQKS ITEMEEKVKK QGDHVRKLKE
860 870 880 890
SGADKSQWQP EVNVLLDLKK QLAELKGEPL PAPSGKKNKK K
Length:891
Mass (Da):100,560
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D3E2BE9EEA8CDD7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAZO01001396 Genomic DNA No translation available.
AAZO01001397 Genomic DNA No translation available.
DS235079 Genomic DNA Translation: EEB11468.1

NCBI Reference Sequences

More...
RefSeqi
XP_002424206.1, XM_002424161.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
PHUM118730-RA; PHUM118730-PA; PHUM118730

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8238335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
phu:Phum_PHUM118730

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
PHUM118730-RA; PHUM118730-PA; PHUM118730

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZO01001396 Genomic DNA No translation available.
AAZO01001397 Genomic DNA No translation available.
DS235079 Genomic DNA Translation: EEB11468.1
RefSeqiXP_002424206.1, XM_002424161.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi121225.PHUM118730-PA

Genome annotation databases

EnsemblMetazoaiPHUM118730-RA; PHUM118730-PA; PHUM118730
GeneIDi8238335
KEGGiphu:Phum_PHUM118730
VectorBaseiPHUM118730-RA; PHUM118730-PA; PHUM118730

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8238335

Phylogenomic databases

InParanoidiE0VDL2
KOiK01874
OMAiKHLMATE
PhylomeDBiE0VDL2

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.30.10, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009068 S15_NS1_RNA-bd
IPR036249 Thioredoxin-like_sf
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR000738 WHEP-TRS_dom
PfamiView protein in Pfam
PF09334 tRNA-synt_1g, 1 hit
PF00458 WHEP-TRS, 2 hits
PRINTSiPR01041 TRNASYNTHMET
SMARTiView protein in SMART
SM00991 WHEP-TRS, 2 hits
SUPFAMiSSF47060 SSF47060, 2 hits
SSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit
PS51185 WHEP_TRS_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE0VDL2_PEDHC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E0VDL2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: December 11, 2019
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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