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Protein

RNA polymerase II transcription factor B subunit 2

Gene

Eint_010550

Organism
Encephalitozoon intestinalis (strain ATCC 50506) (Microsporidian parasite) (Septata intestinalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:Eint_010550Imported
OrganismiEncephalitozoon intestinalis (strain ATCC 50506) (Microsporidian parasite) (Septata intestinalis)Imported
Taxonomic identifieri876142 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000002313 Componenti: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:Eint_010550

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi876142.XP_003072278.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
HOGENOMiHOG000150417
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

E0S5D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENEVSQAWP YPIDIIEYFG MLPEHSKKRL YRAPVFAVSF LKIFDEKTTR
60 70 80 90 100
FIFDLLLKSH SISSLREIKG IKEVLKTLLR IQMIEKKGDN IYLEEDFRRS
110 120 130 140 150
LMEGFCMLTI EKHYRSAGEE TETDEEESNR RFETILRSIV NKESKIREFG
160 170 180 190 200
VREVLMFGGL LGRDENITNR GFEFLLKTKK EQLWCLVLLS LKYFLKSVEE
210 220 230 240 250
EVSTLEAIFE LSTKNVGTVY RHSSSMDKRL LKYLEVLGIL KLYGENLAIR
260 270 280 290 300
RSFVQLFEAS ERNRREFIIV ETNNKIYAYT NSEYEKSVIH LFCNVSFNLP
310 320 330 340 350
NLTKGSITEE SVNAAFDKGI TGRQIIHFLE ASSKPGSLPP AIINQIIIWE
360 370 380 390 400
SKRNRIFMAP GYLYSNFLNL SDYQKVLEFC SERNYLIESD IDRRMIVVNP
410
KGHVFVKEFI KTIL
Length:414
Mass (Da):48,462
Last modified:November 2, 2010 - v1
Checksum:i0E1624CEBFAF630B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001942 Genomic DNA Translation: ADM10918.1
RefSeqiXP_003072278.1, XM_003072232.1

Genome annotation databases

EnsemblFungiiADM10918; ADM10918; Eint_010550
GeneIDi9698541
KEGGiein:Eint_010550

Similar proteinsi

Entry informationi

Entry nameiE0S5D3_ENCIT
AccessioniPrimary (citable) accession number: E0S5D3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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