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Entry version 53 (16 Jan 2019)
Sequence version 1 (02 Nov 2010)
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Protein
Submitted name:

Mannan endo-1,4-beta-mannosidase

Gene

PPE_04361

Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei946Proton donorPROSITE-ProRule annotation1
Active sitei1038NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidasePROSITE-ProRule annotation, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
PPOL349520:G1GMT-4303-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

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CAZyi
CBM3 Carbohydrate-Binding Module Family 3
CBM35 Carbohydrate-Binding Module Family 35
GH26 Glycoside Hydrolase Family 26
GH44 Glycoside Hydrolase Family 44

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mannan endo-1,4-beta-mannosidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PPE_04361Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPaenibacillus polymyxa (strain E681)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri349520 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500313948740 – 1353Sequence analysisAdd BLAST1314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
349520.PPE_04361

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini563 – 653Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini656 – 774CBM6InterPro annotationAdd BLAST119
Domaini795 – 1090GH26InterPro annotationAdd BLAST296
Domaini1107 – 1199Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1199 – 1351CBM3InterPro annotationAdd BLAST153

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 26 family.PROSITE-ProRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105FEP Bacteria
COG2730 LUCA
COG4124 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165573

KEGG Orthology (KO)

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KOi
K01218

Identification of Orthologs from Complete Genome Data

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OMAi
AMSENGP

Database of Orthologous Groups

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OrthoDBi
3323at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.60.40.1180, 1 hit
2.60.40.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR005084 CMB_fam6
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR022790 GH26_dom
IPR000805 Glyco_hydro_26
IPR024745 Glyco_hydro_44
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold

The PANTHER Classification System

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PANTHERi
PTHR40079 PTHR40079, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00942 CBM_3, 1 hit
PF16990 CBM_35, 1 hit
PF02156 Glyco_hydro_26, 1 hit
PF12891 Glyco_hydro_44, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00739 GLHYDRLASE26

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01067 CBM_3, 1 hit
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits
SSF49384 SSF49384, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172 CBM3, 1 hit
PS51175 CBM6, 1 hit
PS50853 FN3, 2 hits
PS51764 GH26, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E0RHJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKNSSSIG YKRSKWLPVV MACTIIVGGA LPTPTVVHGQ TAKTVTIKVD
60 70 80 90 100
TSKDRKPISP YIYGTNQELA GDENLTARRL GGNRMTGYNW ENNMSNAGSD
110 120 130 140 150
WMQSSDSYLC DNAGLTKAEC EKPGAVATSF HDQSLKQGTY SLVTLPMAGY
160 170 180 190 200
VAKDGNGSVQ ESEKAPSARW NEVVNAKNAP FQLQPDLKDN QVYADEFVNF
210 220 230 240 250
LVKKYGSAST KTGVKGYSLD NEPALWSHTH PRIHGEKVGA KELVDRSVSL
260 270 280 290 300
SKAVKAVDAG AEIFGPVLYG FGAYTDLQTA PDWSSVKGNY SWFVDYYLDQ
310 320 330 340 350
MRLSSQAEGK RLLDVFDVHW YPEAMGGGIR ITNEVGNDET KKARMQAPRT
360 370 380 390 400
LWDPTYKEDS WIAQWNSEFL PLLPRLKQSV DKYYPGTKLA LTEYSYGGEN
410 420 430 440 450
DISGGIAMAD VLGILGKNDV YMSNYWKLKD GANNYVSAAY KLYRNYDGKS
460 470 480 490 500
STFGDISVHA QTSDIVNSSV HASVTDASYK ELHLVVMNKS MDSAFDAQFD
510 520 530 540 550
LSGETTYGSG KVWGFDKNSS QIKEAAPITQ ISGNRFTYTV PPLTAYHIVL
560 570 580 590 600
TAGNDTSVPP VEGPESFALR AEAGDGKVDL SWDAFSGVVS YSVQRATYEN
610 620 630 640 650
GPFTAVASNL VETSYTDTNV TNGTSYYYKI TAKTKAGTSE SNVLKAVPQT
660 670 680 690 700
PVDGQDRYEA EDGTLKGTTV ESSGTGFSGT GYVTNFHNAG DSLTMTIQAE
710 720 730 740 750
AAGLYNLTIG YRSPYDDKRT NFSLNGKASG ELILSKSADF KETSGGKVLL
760 770 780 790 800
NAGANTIGFE TGWGWYDIDY VKLKPAADRP PHAVTKTLTN PNATVEARAL
810 820 830 840 850
MNYLVDQYGK NMLSGQEEIT EIDWLQANVG KKPAIAALDL IDYSPSRAEH
860 870 880 890 900
GLSSTETEKA IAWDKQGGIV TFAWHWNAPK GLIDTQGKEW WRGFYADSTT
910 920 930 940 950
FDIEYAMNHP ESEDYKLLIR DIDVIAGQLK KLQDAKVPVL FRPLHEAEGK
960 970 980 990 1000
WFWWGAKGPE PVKKLYILMH DRLTNVHKLN NLIWVWNSVA PDWYPGDEYV
1010 1020 1030 1040 1050
DILSFDSYPQ AGDYSPQIAK YEDLVTLGKD KKLVAMSENG PIPDPDLMKA
1060 1070 1080 1090 1100
YQAHWSWFAT WYGDFLRDGK QNSLEHLKKV YNHPNVITLE KLPTNLKTYG
1110 1120 1130 1140 1150
ITEQPSVPGS FTLNAAGETA KVKLSWTASA NAASYEVKRS TAENGAFATV
1160 1170 1180 1190 1200
ASDVYGSSYT DTAVTADTMY YYQVVAKNDA GQTVSNTASA APKADTQQPT
1210 1220 1230 1240 1250
TGLVLQYRTA DTNVNDNHLN PHFQIVNKGT TSIPISELKI RYYYTIDGDR
1260 1270 1280 1290 1300
EQTFNCDYAM LGCSKLNGKL VMEKAATGAD YYLEVSFNPD AGVLAPGGST
1310 1320 1330 1340 1350
GEIQTRIHKT DWSNYNESDD YSYKGTQTSF ADHTKATLYH NGILVWGTEP

TAN
Length:1,353
Mass (Da):148,881
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i919C350166BC751D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP000154 Genomic DNA Translation: ADM72121.1

NCBI Reference Sequences

More...
RefSeqi
WP_013312232.1, NC_014483.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADM72121; ADM72121; PPE_04361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ppy:PPE_04361

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000154 Genomic DNA Translation: ADM72121.1
RefSeqiWP_013312232.1, NC_014483.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi349520.PPE_04361

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
CBM35 Carbohydrate-Binding Module Family 35
GH26 Glycoside Hydrolase Family 26
GH44 Glycoside Hydrolase Family 44

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADM72121; ADM72121; PPE_04361
KEGGippy:PPE_04361

Phylogenomic databases

eggNOGiENOG4105FEP Bacteria
COG2730 LUCA
COG4124 LUCA
HOGENOMiHOG000165573
KOiK01218
OMAiAMSENGP
OrthoDBi3323at2

Enzyme and pathway databases

BioCyciPPOL349520:G1GMT-4303-MONOMER

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.60.40.1180, 1 hit
2.60.40.710, 1 hit
InterProiView protein in InterPro
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR005084 CMB_fam6
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR022790 GH26_dom
IPR000805 Glyco_hydro_26
IPR024745 Glyco_hydro_44
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PANTHERiPTHR40079 PTHR40079, 1 hit
PfamiView protein in Pfam
PF00942 CBM_3, 1 hit
PF16990 CBM_35, 1 hit
PF02156 Glyco_hydro_26, 1 hit
PF12891 Glyco_hydro_44, 1 hit
PRINTSiPR00739 GLHYDRLASE26
SMARTiView protein in SMART
SM01067 CBM_3, 1 hit
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 2 hits
SSF49384 SSF49384, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 2 hits
PROSITEiView protein in PROSITE
PS51172 CBM3, 1 hit
PS51175 CBM6, 1 hit
PS50853 FN3, 2 hits
PS51764 GH26, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE0RHJ0_PAEP6
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E0RHJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 16, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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