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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bifidobacterium dentium ATCC 27679
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei766ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:HMPREF0168_0620Imported
OrganismiBifidobacterium dentium ATCC 27679Imported
Taxonomic identifieri871562 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000003323 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 155tRNA-synt_1gInterPro annotationAdd BLAST83
Domaini310 – 500tRNA-synt_1_2InterPro annotationAdd BLAST191
Domaini840 – 954Anticodon_1InterPro annotationAdd BLAST115

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi763 – 767"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

E0Q663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTEKSAQA QSNESAEPSF RYNAKLAQGV EEKWQKIWDD EGTFWAANVN
60 70 80 90 100
GELKDGKGHN AEGRPSYFAM DMFPYPSGKG LHVGHPLGYL ATDVVSRYHR
110 120 130 140 150
MKGENVLHAM GYDAFGLPAE QYAVQTGQHP RITTEQNIAN MRRQLHRMGL
160 170 180 190 200
SFDNRRSFAT IDPGYVRWTQ WIFSRIYDAW YDEEAVNPSG SKGCARPISE
210 220 230 240 250
LVEQFESGAR AIPGCEGRSW ADLNEAERAD VLNDFRLAYI SKSPVNWCPG
260 270 280 290 300
LGTVLANEEV TAEGKSERGN FPVFQRELRQ WSMRITAYGH RLIEDLDGID
310 320 330 340 350
WPEKVKLMQR NWIGESHGAS VHFTVETPNG IRDMEIYTTR PDTLFGTTFA
360 370 380 390 400
VVSPEHHLLA DVPDEWPAET PENWKGGYAT PVEAVQSYRL AAEAKTAKDR
410 420 430 440 450
VDEAGEKTGL FTGLYAINPI TGAKLPLFTA DYVLMDYGTG AIMAVPGGDQ
460 470 480 490 500
RDYDFAVKFG LPVIYTVKPL PESGDDLADY EGKAPFVSHD GIVINSSVAS
510 520 530 540 550
TKAKGDALSL DGLRVDEAID KVNAWLESAG VGKGTVSYRL RDWLFSRQRY
560 570 580 590 600
WGEPFPIVYG EDGTPHLLPD EQLPINLPDV PDYSPKTFDP EDAESNPEAP
610 620 630 640 650
LSRNEDWVKV ELDLGDGKKT YYRDTNTMPN WAGSCWYYMR YLDPTDTEHM
660 670 680 690 700
VEKDEYDYWM GPNHNETTGK AGGVDLYIGG VEHAVLHLLY SRFWHKVLFD
710 720 730 740 750
LGFVDSAEPF HKLFNQGMIQ AYAYTDDRGQ YVPAAEVVEG PADANGEPTF
760 770 780 790 800
TWNGEHANRE FGKMGKSLKN IITPDDMYEN YGADTFRLYE MGMGPLAESR
810 820 830 840 850
PWNTRNVVGS MRFLQRLWRN VIDETTGEVR VSEGDLDSKT LKLLNNTIAD
860 870 880 890 900
VTVEMEAMRP NTAIAKLIVL NNHLTGLDDV PRAAIEPLIL MLSPIAPHIC
910 920 930 940 950
EELWNRLGHD ESLAHADWPK ADERYVGQDT VTAVVQIKGK VRAKLEVTPD
960 970 980 990
IDPKELEQMA LEAVADRLGG KEPRKVIVKA PKIVSIVPAE
Length:990
Mass (Da):110,946
Last modified:November 2, 2010 - v1
Checksum:iFA5C4841A4B3BDFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEEQ01000007 Genomic DNA Translation: EFM42137.1
RefSeqiWP_003841663.1, NZ_GL405225.1

Genome annotation databases

EnsemblBacteriaiEFM42137; EFM42137; HMPREF0168_0620

Similar proteinsi

Entry informationi

Entry nameiE0Q663_9BIFI
AccessioniPrimary (citable) accession number: E0Q663
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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