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UniProtKB - E0IWE7 (E0IWE7_ECOLW)

Entry version 46 (10 Feb 2021)
Sequence version 1 (02 Nov 2010)
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Protein
Submitted name:

Xanthine dehydrogenase, molybdenum binding subunit

Gene

xdhA

Organism
Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / NCIMB 8666 / NRRL B-766 / W)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Xanthine dehydrogenase, molybdenum binding subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xdhAImported
Ordered Locus Names:ECW_m3119Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / NCIMB 8666 / NRRL B-766 / W)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri566546 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008525 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 139Ald_Xan_dh_CInterPro annotationAdd BLAST117

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		ANRVPVH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000674, Ald_Oxase/Xan_DH_a/b
IPR036856, Ald_Oxase/Xan_DH_a/b_sf
IPR008274, AldOxase/xan_DH_Mopterin-bd
IPR037165, AldOxase/xan_DH_Mopterin-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01315, Ald_Xan_dh_C, 1 hit
PF02738, Ald_Xan_dh_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01008, Ald_Xan_dh_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54665, SSF54665, 1 hit
SSF56003, SSF56003, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E0IWE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAREATATG ESCMRVDAIA KVTGRARYTD DYVMAGMCYA KYVRSPIAHG 
        60         70         80         90        100
YAVSINDEQA RSLPGVLAIF TWEDVPDIPF ATAGHAWTLD ENKRDTADRA 
       110        120        130        140        150
LLTRHVRHHG DAVAIVVARD ELTAEKAAQL VSIEWQELPV ITTPEAALAE 
       160        170        180        190        200
DAAPIHNGGN LLKQSTMSTG NVQQTIDAAD YQVQGHYQTP VIQHCHMESV 
       210        220        230        240        250
TSLAWMEDDS RITIVSSTQI PHIVRRVVGQ ALDIPWSCVR VIKPFVGGGF 
       260        270        280        290        300
GNKQDVLEEP MAAFLTSKLG GIPVKVSLSR EECFLATRTR HAFTIDGQMG 
       310        320        330        340        350
VNRDGTLKGY SLDVLSNTGA YASHGHSIAS AGGNKVAYLY PRCAYAYSSK 
       360        370        380        390        400
TCYTNLPSAG AMRGYGAPQV VFAVESMLDD AATALGIDPV EIRLRNAARE 
       410        420        430        440        450
GDANPLTGKR IYSAGLPECL EKGRKIFEWE KRRAECQNQQ GNLRRGVGVA 
       460        470        480        490        500
CFSYTSNTWP VGVEIAGARL LMNQDGTINV QSGATEIGQG ADTVFSQMVA 
       510        520        530        540        550
ETVGVPVSDV RVISTQDTDV TPFDPGAFAS RQSYVAAPAL RSAALLLKEK 
       560        570        580        590        600
IIAHAAVMLH QSAMNLTLIK GHIVLVERPE EPLMSLKDLA MDAFYHPERG 
       610        620        630        640        650
GQLSAESSIK TTTNPPAFGC TFVDLTVDIA LCKVTINRIL NVHDSGHILN 
       660        670        680        690        700
PLLAEGQVHG GMGMGIGWAL FEEMIIDAKS GVVRNPNLLD YKMPTMPDLP 
       710        720        730        740        750
QLESAFVEIN EPQSAYGHKS LGEPPIIPVA AAIRNAVKMA TGVAINTLPL 
       760 
TPKRLYEEFH LAGLI
Length:765
Mass (Da):82,658
Last modified:November 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56854064C4277F9B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP002185 Genomic DNA Translation: ADT76497.1

NCBI Reference Sequences

More...RefSeqi		WP_000388150.1, NZ_WBMH01000020.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ADT76497; ADT76497; ECW_m3119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		elw:ECW_m3119

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|566546.30.peg.3171

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002185 Genomic DNA Translation: ADT76497.1
RefSeqiWP_000388150.1, NZ_WBMH01000020.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiADT76497; ADT76497; ECW_m3119
KEGGielw:ECW_m3119
PATRICifig|566546.30.peg.3171

Phylogenomic databases

OMAiANRVPVH

Family and domain databases

InterProiView protein in InterPro
IPR000674, Ald_Oxase/Xan_DH_a/b
IPR036856, Ald_Oxase/Xan_DH_a/b_sf
IPR008274, AldOxase/xan_DH_Mopterin-bd
IPR037165, AldOxase/xan_DH_Mopterin-bd_sf
PfamiView protein in Pfam
PF01315, Ald_Xan_dh_C, 1 hit
PF02738, Ald_Xan_dh_C2, 1 hit
SMARTiView protein in SMART
SM01008, Ald_Xan_dh_C, 1 hit
SUPFAMiSSF54665, SSF54665, 1 hit
SSF56003, SSF56003, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE0IWE7_ECOLW
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E0IWE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 10, 2021
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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