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Protein
Submitted name:

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1Imported
Gene namesi
Name:Nrxn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1096391 Nrxn1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiE0CZA5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024109 Expressed in 194 organ(s), highest expression level in visual cortex
ExpressionAtlasiE0CZA5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE0CZA5
SMRiE0CZA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 255LAM_G_DOMAINInterPro annotationAdd BLAST169

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 3 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

E0CZA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYQRMLRCGA DLGSPGGGSG GGAGGRLALI WIVPLTLSGL LGVAWGASSL
60 70 80 90 100
GAHHIHHFHG SSKHHSVPIA IYRSPASLRG GHAGTTYIFS KGGGQITYKW
110 120 130 140 150
PPNDRPSTRA DRLAIGFSTV QKEAVLVRVD SSSGLGDYLE LHIHQGKIGV
160 170 180 190 200
KFNVGTDDIA IEESNAIIND GKYHVVRFTR SGGNATLQVD SWPVIERYPA
210 220 230 240 250
GRQLTIFNSQ ATIIIGGKEQ GQPFQGQLSG LYYNGLKVLN MAAENDANIA
260 270 280 290 300
IVGNVRLVGE VPSSMTTEST ATAMQSEMST SIMETTTTLA TSTARRGKPP
310 320 330 340 350
TKEPISQTTD DILVASAECP SDDEDIDPCE PSSGGLANPT RVGGREPYPG
360 370 380 390 400
SAEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYHVDESR
410 420 430
NYISNSAQSN GAVVKEKQPS SAKSANKNKK NKDKEYYV
Length:438
Mass (Da):46,660
Last modified:July 22, 2015 - v2
Checksum:i75DD733041D40A8D
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CS84NRX1A_MOUSE
Neurexin-1
Nrxn1 Kiaa0578
1,514Annotation score:
E0CY11E0CY11_MOUSE
Neurexin-1
Nrxn1
1,495Annotation score:
A0A0H2UH29A0A0H2UH29_MOUSE
Neurexin-1
Nrxn1
465Annotation score:
G3UWQ9G3UWQ9_MOUSE
Neurexin-1
Nrxn1
142Annotation score:
A0A0G2JE40A0A0G2JE40_MOUSE
Neurexin-1
Nrxn1
186Annotation score:
H3BK41H3BK41_MOUSE
Neurexin-1
Nrxn1
213Annotation score:
H3BK93H3BK93_MOUSE
Neurexin-1
Nrxn1
327Annotation score:
A0A0G2JE65A0A0G2JE65_MOUSE
Neurexin-1
Nrxn1
169Annotation score:
A0A0G2JES8A0A0G2JES8_MOUSE
Neurexin-1
Nrxn1
172Annotation score:
A0A140LI71A0A140LI71_MOUSE
Neurexin-1
Nrxn1
75Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101872 Genomic DNA No translation available.
AC131326 Genomic DNA No translation available.
AC151286 Genomic DNA No translation available.
AC154325 Genomic DNA No translation available.
AC154599 Genomic DNA No translation available.
AC167814 Genomic DNA No translation available.
AC170901 Genomic DNA No translation available.
AC171209 Genomic DNA No translation available.
CT025708 Genomic DNA No translation available.
CT486002 Genomic DNA No translation available.
RefSeqiNP_001333889.1, NM_001346960.1
UniGeneiMm.478418
Mm.491332

Genome annotation databases

EnsembliENSMUST00000159778; ENSMUSP00000125561; ENSMUSG00000024109
GeneIDi18189
UCSCiuc008dwc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101872 Genomic DNA No translation available.
AC131326 Genomic DNA No translation available.
AC151286 Genomic DNA No translation available.
AC154325 Genomic DNA No translation available.
AC154599 Genomic DNA No translation available.
AC167814 Genomic DNA No translation available.
AC170901 Genomic DNA No translation available.
AC171209 Genomic DNA No translation available.
CT025708 Genomic DNA No translation available.
CT486002 Genomic DNA No translation available.
RefSeqiNP_001333889.1, NM_001346960.1
UniGeneiMm.478418
Mm.491332

3D structure databases

ProteinModelPortaliE0CZA5
SMRiE0CZA5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE0CZA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159778; ENSMUSP00000125561; ENSMUSG00000024109
GeneIDi18189
UCSCiuc008dwc.1 mouse

Organism-specific databases

CTDi9378
MGIiMGI:1096391 Nrxn1

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991

Miscellaneous databases

ChiTaRSiNrxn1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024109 Expressed in 194 organ(s), highest expression level in visual cortex
ExpressionAtlasiE0CZA5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 3 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE0CZA5_MOUSE
AccessioniPrimary (citable) accession number: E0CZA5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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