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UniProtKB - E0CZ12 (E0CZ12_MOUSE)
Protein
Runt-related transcription factor
Gene
Runx2
Organism
Mus musculus (Mouse)
Status
Functioni
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
UniRule annotationGO - Molecular functioni
- ATP binding Source: InterPro
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific double-stranded DNA binding Source: UniProt
GO - Biological processi
- cell differentiation Source: UniProt
- positive regulation of developmental process Source: UniProt
- positive regulation of multicellular organismal process Source: UniProt
- positive regulation of transcription, DNA-templated Source: UniProtKB-UniRule
- regulation of signal transduction Source: UniProt
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Runt-related transcription factorUniRule annotation |
Gene namesi | Name:Runx2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99829, Runx2 |
VEuPathDBi | HostDB:ENSMUSG00000039153 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000039153, Expressed in hindlimb long bone and 317 other tissues |
ExpressionAtlasi | E0CZ12, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 222 | RuntInterPro annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 180 – 199 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 210 – 240 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 362 – 421 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 57 | Polar residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 210 – 229 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 369 – 412 | Polar residuesSequence analysisAdd BLAST | 44 |
Phylogenomic databases
GeneTreei | ENSGT00940000160171 |
HOGENOMi | CLU_032910_0_0_1 |
OrthoDBi | 562214at2759 |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit 4.10.770.10, 1 hit |
InterProi | View protein in InterPro IPR000040, AML1_Runt IPR021216, DUF2722 IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR013524, Runt_dom IPR027384, Runx_central_dom_sf IPR013711, RunxI_C_dom IPR016554, TF_Runt-rel_RUNX |
PANTHERi | PTHR11950, PTHR11950, 2 hits |
Pfami | View protein in Pfam PF10846, DUF2722, 1 hit PF00853, Runt, 1 hit PF08504, RunxI, 1 hit |
PIRSFi | PIRSF009374, TF_Runt-rel_RUNX, 2 hits |
PRINTSi | PR00967, ONCOGENEAML1 |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS51062, RUNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
E0CZ12-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRIPVDPSTS RRFSPPSSSL QPGKMSDVSP VVAAQQQQQQ QQQQQQQQQQ
60 70 80 90 100
QQQQQQQQQQ QQQEAAAAAA AAAAAAAAAA AAVPRLRPPH DNRTMVEIIA
110 120 130 140 150
DHPAELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGE VPDGTVVTVM
160 170 180 190 200
AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRDPRQ AQSSPPWSYD
210 220 230 240 250
QSYPSYLSQM TSPSIHSTTP LSSTRGTGLP AITDVPRRIS DDDTATSDFC
260 270 280 290 300
LWPSSLSKKS QAGASELGPF SDPRQFPSIS SLTESRFSNP RMHYPATFTY
310 320 330 340 350
TPPVTSGMSL GMSATTHYHT YLPPPYPGSS QSQSGPFQTS STPYLYYGTS
360 370 380 390 400
SASYQFPMVP GGDRSPSRMV PPCTTTSNGS TLLNPNLPNQ NDGVDADGSH
410 420
SSSPTVLNSS GRMDESVWRP Y
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ08775 | RUNX2_MOUSE | Runt-related transcription factor 2 | Runx2 Aml3, Cbfa1, Osf2, Pebp2a | 607 | Annotation score: | ||
F8WHN7 | F8WHN7_MOUSE | Runt-related transcription factor | Runx2 | 514 | Annotation score: | ||
E0CY45 | E0CY45_MOUSE | Runt-related transcription factor | Runx2 | 492 | Annotation score: | ||
E9PUK7 | E9PUK7_MOUSE | Runt-related transcription factor | Runx2 | 506 | Annotation score: | ||
F6TRA6 | F6TRA6_MOUSE | Runt-related transcription factor 2 | Runx2 | 231 | Annotation score: | ||
E0CZC6 | E0CZC6_MOUSE | Runt-related transcription factor 2 | Runx2 | 283 | Annotation score: | ||
F7CZB5 | F7CZB5_MOUSE | Runt-related transcription factor 2 | Runx2 | 147 | Annotation score: | ||
F7CN98 | F7CN98_MOUSE | Runt-related transcription factor 2 | Runx2 | 51 | Annotation score: | ||
Q1PAG7 | Q1PAG7_MOUSE | Runt-related transcription factor 2 | Runx2 | 106 | Annotation score: |
Sequence databases
RefSeqi | NP_001258560.1, NM_001271631.1 |
Genome annotation databases
Ensembli | ENSMUST00000162878.8; ENSMUSP00000123707.2; ENSMUSG00000039153.18 |
GeneIDi | 12393 |
UCSCi | uc012aty.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001258560.1, NM_001271631.1 |
3D structure databases
SMRi | E0CZ12 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E0CZ12 |
ProteomicsDBi | 367437 |
Protocols and materials databases
Antibodypediai | 3645, 893 antibodies from 45 providers |
DNASUi | 12393 |
Genome annotation databases
Ensembli | ENSMUST00000162878.8; ENSMUSP00000123707.2; ENSMUSG00000039153.18 |
GeneIDi | 12393 |
UCSCi | uc012aty.2, mouse |
Organism-specific databases
CTDi | 860 |
MGIi | MGI:99829, Runx2 |
VEuPathDBi | HostDB:ENSMUSG00000039153 |
Phylogenomic databases
GeneTreei | ENSGT00940000160171 |
HOGENOMi | CLU_032910_0_0_1 |
OrthoDBi | 562214at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12393, 5 hits in 75 CRISPR screens |
ChiTaRSi | Runx2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039153, Expressed in hindlimb long bone and 317 other tissues |
ExpressionAtlasi | E0CZ12, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit 4.10.770.10, 1 hit |
InterProi | View protein in InterPro IPR000040, AML1_Runt IPR021216, DUF2722 IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR013524, Runt_dom IPR027384, Runx_central_dom_sf IPR013711, RunxI_C_dom IPR016554, TF_Runt-rel_RUNX |
PANTHERi | PTHR11950, PTHR11950, 2 hits |
Pfami | View protein in Pfam PF10846, DUF2722, 1 hit PF00853, Runt, 1 hit PF08504, RunxI, 1 hit |
PIRSFi | PIRSF009374, TF_Runt-rel_RUNX, 2 hits |
PRINTSi | PR00967, ONCOGENEAML1 |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS51062, RUNT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E0CZ12_MOUSE | |
Accessioni | E0CZ12Primary (citable) accession number: E0CZ12 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2010 |
Last sequence update: | October 5, 2010 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |