Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent T-type calcium channel subunit alpha

Gene

Cacna1i

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1iImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2178051 Cacna1i

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei206 – 230HelicalSequence analysisAdd BLAST25
Transmembranei343 – 364HelicalSequence analysisAdd BLAST22
Transmembranei370 – 395HelicalSequence analysisAdd BLAST26
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23
Transmembranei762 – 778HelicalSequence analysisAdd BLAST17
Transmembranei798 – 820HelicalSequence analysisAdd BLAST23
Transmembranei1130 – 1148HelicalSequence analysisAdd BLAST19
Transmembranei1168 – 1189HelicalSequence analysisAdd BLAST22
Transmembranei1201 – 1227HelicalSequence analysisAdd BLAST27
Transmembranei1265 – 1287HelicalSequence analysisAdd BLAST23
Transmembranei1366 – 1390HelicalSequence analysisAdd BLAST25
Transmembranei1446 – 1463HelicalSequence analysisAdd BLAST18
Transmembranei1483 – 1502HelicalSequence analysisAdd BLAST20
Transmembranei1566 – 1593HelicalSequence analysisAdd BLAST28
Transmembranei1668 – 1689HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiE0CXK2

PTM databases

SwissPalmiE0CXK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000022416 Expressed in 23 organ(s), highest expression level in cerebellum
ExpressionAtlasiE0CXK2 baseline and differential

Structurei

3D structure databases

SMRiE0CXK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 406Ion_transInterPro annotationAdd BLAST331
Domaini598 – 825Ion_transInterPro annotationAdd BLAST228
Domaini1128 – 1400Ion_transInterPro annotationAdd BLAST273
Domaini1446 – 1699Ion_transInterPro annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1399 – 1426Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00830000128242
OMAiSWNSLAR
PhylomeDBiE0CXK2

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR030162 CACNA1I
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF209 PTHR10037:SF209, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01629 TVDCCALPHA1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E0CXK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSNLPPSS SAAPDPEPGI TEQPGPRSPP PSPPGLEEPL DGTNPDVPHP
60 70 80 90 100
DLAPVAFFCL RQTTSPRNWC IKMVCNPWFE CVSMLVILLN CVTLGMYQPC
110 120 130 140 150
DDMECLSDRC KILQVFDDFI FIFFAMEMVL KMVALGIFGK KCYLGDTWNR
160 170 180 190 200
LDFFIVMAGM VEYSLDLQNI NLSAIRTVRV LRPLKAINRV PSMRILVNLL
210 220 230 240 250
LDTLPMLGNV LLLCFFVFFI FGIIGVQLWA GLLRNRCFLE ENFTIQGDVA
260 270 280 290 300
LPPYYQPEED DEMPFICSLS GDNGIMGCHE IPPLKEQGRE CCLSKDDMYD
310 320 330 340 350
FGAGRQDLNA SGLCVNWNRY YNVCRTGNAN PHKGAINFDN IGYAWIVIFQ
360 370 380 390 400
VITLEGWVEI MYYVMDAHSF YNFIYFILLI IVGSFFMINL CLVVIATQFS
410 420 430 440 450
ETKQREHRLM LEQRQRYLSS STVASYAEPG DCYEEIFQYV CHILRKAKRR
460 470 480 490 500
ALGLYQALQN RRQATGPGTP APAKPGPHAK EPSHCKLCPR HSPLDTTPHT
510 520 530 540 550
LVQPISAILA SDPSSCPRCQ HEAGRRPSGL GSTDSGQEGS GSGGSAEAEA
560 570 580 590 600
NGDGPQSSED GVSSGLGKEE EQEDGAARLC GDVWRETRAK LRGIVDSKYF
610 620 630 640 650
NRGIMMAILV NTVSMGIEHH EQPEELTNIL EICNVVFTSM FALEMILKLA
660 670 680 690 700
AFGLFDYLRN PYNIFDSIIV IISIWEIVGQ ADGGLSVLRT FRLLRVLKLV
710 720 730 740 750
RFMPALRRQL VVLMKTMDNV ATFCMLLMLF IFIFSILGMH IFGCKFSLRT
760 770 780 790 800
DTGDTVPDRK NFDSLLWAIV TVFQILTQED WNVVLYNGMA STTPWASLYF
810 820 830 840 850
VALMTFGNYV LFNLLVAILV EGFQAEGDAN RSYSDEDQSS SNLEELDKLP
860 870 880 890 900
EGLDSSRDLK LCPIPMTPNG HLDPSLPLGG HLGPAGAMGA APRLSLQPDP
910 920 930 940 950
VLVALESRKS SVMSLGRMSY DQRSLSSSRS SYYGPWGRSG TWASRRSSWN
960 970 980 990 1000
SLKHKPPSAE HESLLSGERG GSCVRACEGA REDAPPRAAP LHAPHTHHAH
1010 1020 1030 1040 1050
HGPHLAHRHR HHRRTLSLDT RDSVDLAELV PVVGAHSRAA WRAAGQAPGH
1060 1070 1080 1090 1100
EDCNGRMPNI AKDVFTKMDD RRDRGEDEEE IDYTLCFRVR KMIDVYKPDW
1110 1120 1130 1140 1150
CEVREDWSVY LFSPENKFRI LCQTIIAHKL FDYVVLAFIF LNCITIALER
1160 1170 1180 1190 1200
PQIEAGSTER IFLTVSNYIF TAIFVGEMTL KVVSLGLYFG EQAYLRSSWN
1210 1220 1230 1240 1250
VLDGFLVFVS IIDIVVSVAS AGGAKILGVL RVLRLLRTLR PLRVISRAPG
1260 1270 1280 1290 1300
LKLVVETLIS SLKPIGNIVL ICCAFFIIFG ILGVQLFKGK FYHCLGVDTR
1310 1320 1330 1340 1350
NITNRSDCVA ANYRWVHHKY NFDNLGQALM SLFVLASKDG WVNIMYNGLD
1360 1370 1380 1390 1400
AVAVDQQPVT NHNPWMLLYF ISFLLIVSFF VLNMFVGVVV ENFHKCRQHQ
1410 1420 1430 1440 1450
EAEEARRREE KRLRRLEKKR RKAQRLPYYA TYCPTRLLIH SMCTSHYLDI
1460 1470 1480 1490 1500
FITFIICLNV VTMSLEHYNQ PTSLETALKY CNYMFTTVFV LEAVLKLVAF
1510 1520 1530 1540 1550
GLRRFFKDRW NQLDLAIVLL SVMGITLEEI EINAALPINP TIIRIMRVLR
1560 1570 1580 1590 1600
IARVLKLLKM ATGMRALLDT VVQALPQVGN LGLLFMLLFF IYAALGVELF
1610 1620 1630 1640 1650
GKLVCNDENP CEGMSRHATF ENFGMAFLTL FQVSTGDNWN GIMKDTLRDC
1660 1670 1680 1690 1700
THDERSCLSS LQFVSPLYFV SFVLTAQFVL INVVVAVLMK HLDDSNKEAQ
1710 1720 1730 1740 1750
EDAEMDAEIE LEMAHGLGPG PGPCPCPCPC PCPCPCPGPR MPTSSPGAPG
1760 1770 1780 1790 1800
RGSGGAGVGG DTESHLCRHC YSPAQETLWL DSVSLIIKDS LEGELTIIDN
1810 1820 1830
LSGSIFHHYS SPAGCDKCHH DKQETGPRPS CWGMT
Length:1,835
Mass (Da):205,417
Last modified:October 5, 2010 - v1
Checksum:i02A75351A1373D4B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q7P2E9Q7P2_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1i
2,199Annotation score:
F7BQ85F7BQ85_MOUSE
Calcium channel, voltage-dependent,...
Cacna1i
105Annotation score:
F6TAX9F6TAX9_MOUSE
Calcium channel, voltage-dependent,...
Cacna1i
132Annotation score:
F6V0N5F6V0N5_MOUSE
Calcium channel, voltage-dependent,...
Cacna1i
260Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155313 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000162155; ENSMUSP00000125229; ENSMUSG00000022416

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155313 Genomic DNA No translation available.

3D structure databases

SMRiE0CXK2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiE0CXK2

Proteomic databases

PRIDEiE0CXK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162155; ENSMUSP00000125229; ENSMUSG00000022416

Organism-specific databases

MGIiMGI:2178051 Cacna1i

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00830000128242
OMAiSWNSLAR
PhylomeDBiE0CXK2

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022416 Expressed in 23 organ(s), highest expression level in cerebellum
ExpressionAtlasiE0CXK2 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR030162 CACNA1I
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF209 PTHR10037:SF209, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01629 TVDCCALPHA1
ProtoNetiSearch...

Entry informationi

Entry nameiE0CXK2_MOUSE
AccessioniPrimary (citable) accession number: E0CXK2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again