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Protein
Submitted name:

Glutamate receptor-interacting protein 2

Gene

Grip2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor-interacting protein 2Imported
Gene namesi
Name:Grip2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2681173 Grip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiE0CXE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030098 Expressed in 222 organ(s), highest expression level in cumulus cell
ExpressionAtlasiE0CXE0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE0CXE0
SMRiE0CXE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84PDZInterPro annotationAdd BLAST84
Domaini101 – 187PDZInterPro annotationAdd BLAST87
Domaini201 – 285PDZInterPro annotationAdd BLAST85
Domaini406 – 481PDZInterPro annotationAdd BLAST76
Domaini507 – 591PDZInterPro annotationAdd BLAST85
Domaini606 – 688PDZInterPro annotationAdd BLAST83

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00920000149078

Family and domain databases

InterProiView protein in InterPro
IPR030029 GRIP2
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR10316:SF42 PTHR10316:SF42, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 6 hits
SMARTiView protein in SMART
SM00228 PDZ, 6 hits
SUPFAMiSSF50156 SSF50156, 6 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E0CXE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVELIKREGS TLGLTISGGT DKDGKPRVSN LRPGGLAARS DLLNVGDYIR
60 70 80 90 100
SVNGIHLTRL RHDEIITLLK NVGERVVLEV EYELPPPAPE NNPRIISKTV
110 120 130 140 150
DVSLYKEGNS FGFVLRGGAH EDLHKSRPLV LTYVRPGGPA DREGSLKVGD
160 170 180 190 200
RLLSIDGIPL HGASHATAIA TLQQCSHEAL FQVEYDVATP DTVANASGPL
210 220 230 240 250
VVEIAKTPGS ALGISLTTGS HRNKPAITID RIKPASVVDR SGALHAGDHI
260 270 280 290 300
LAIDGTSTEH CSLVEATKLL ASVTEKVRLE ILPSPQSRRP LKPPEAVRIQ
310 320 330 340 350
RSEQLHRWDP SAPSCHSPRP SHCRAPTWAA GGPDQSRSVS STPFSSPTMN
360 370 380 390 400
PAFPCANAST LPRGPMSPRT TAGRRRQRRK EHRSSLSLAS STVGPGGQIV
410 420 430 440 450
HTETTEVVLC GDPLSGFGLQ LQGGIFATET LSSPPLVRFI EPDSPAERCG
460 470 480 490 500
LLQVGDRVLA INGIATEDGT MEEANQLLRD AALARKVVLE IEFDVAESVI
510 520 530 540 550
PSSGTFHVKL PKRRGVELGI TISSASRKRG EPLIISDIKK GSVAHRTGTL
560 570 580 590 600
EPGDKLLAID NIRLDHCPME DAVQILRQCE DLVKLKIRKD EDNSDEQESS
610 620 630 640 650
GAVSYTVELK RYGGPLGITI SGTEEPFDPI IISGLTKRGL AERTGAIHVG
660 670 680 690 700
DRILAINSVS LKGRPLSEAI HLLQVAGETV TLKIKKQLDR PLLPRQSGSL
710 720 730 740 750
SEASDVDEDP PEALKGGLLA TRFSPAVPSV DSAVESWGSS ATDGGFGGTG
760 770 780 790 800
SYTPQVAVRS VTPQEWRPSR LKSSPPPLEP RRTSYTPGPS DESFPEEEGD
810 820
WEPPMRRPVS PLSTPSHLPL F
Length:821
Mass (Da):88,056
Last modified:October 5, 2010 - v1
Checksum:iC71BD0B71D6B760C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XA20G3XA20_MOUSE
Glutamate receptor-interacting prot...
Grip2 mCG_130431
1,042Annotation score:
E0CXS4E0CXS4_MOUSE
Glutamate receptor-interacting prot...
Grip2
1,001Annotation score:
E0CYS1E0CYS1_MOUSE
Glutamate receptor-interacting prot...
Grip2
174Annotation score:
F7BQ55F7BQ55_MOUSE
Glutamate receptor-interacting prot...
Grip2
119Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118245 Genomic DNA No translation available.
AC162914 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000162293; ENSMUSP00000124717; ENSMUSG00000030098

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118245 Genomic DNA No translation available.
AC162914 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE0CXE0
SMRiE0CXE0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE0CXE0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162293; ENSMUSP00000124717; ENSMUSG00000030098

Organism-specific databases

MGIiMGI:2681173 Grip2

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00920000149078

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030098 Expressed in 222 organ(s), highest expression level in cumulus cell
ExpressionAtlasiE0CXE0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR030029 GRIP2
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR10316:SF42 PTHR10316:SF42, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 6 hits
SMARTiView protein in SMART
SM00228 PDZ, 6 hits
SUPFAMiSSF50156 SSF50156, 6 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE0CXE0_MOUSE
AccessioniPrimary (citable) accession number: E0CXE0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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