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Entry version 84 (29 Sep 2021)
Sequence version 1 (05 Oct 2010)
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Protein

Alpha N-catenin

Gene

Ctnna2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinARBA annotation
Biological processCell adhesionARBA annotation, DifferentiationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha N-cateninARBA annotation
Alternative name(s):
Catenin alpha-2ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ctnna2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88275, Ctnna2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000063063

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junctionARBA annotation, Cell membraneARBA annotation, Cell projectionARBA annotation, CytoplasmARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E0CXB9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E0CXB9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E0CXB9

PeptideAtlas

More...
PeptideAtlasi
E0CXB9

PRoteomics IDEntifications database

More...
PRIDEi
E0CXB9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
367514

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E0CXB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063063, Expressed in midbrain and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E0CXB9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E0CXB9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni925 – 952DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili92 – 112Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi925 – 944Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234543

Database of Orthologous Groups

More...
OrthoDBi
953344at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E0CXB9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR001033, Alpha_catenin
IPR030046, CTNNA2
IPR006077, Vinculin/catenin
IPR000633, Vinculin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR18914:SF23, PTHR18914:SF23, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01044, Vinculin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00805, ALPHACATENIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47220, SSF47220, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00663, VINCULIN_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E0CXB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDIHSSYTY TGSMTSATSP IILKWDPKSL EIRTLTVERL LEPLVTQVTT
60 70 80 90 100
LVNTSNKGPS GKKKGRSKKA HVLAASVEQA TQNFLEKGEQ IAKESQDLKE
110 120 130 140 150
ELVAAVEDVR KQGETMRIAS SEFADDPCSS VKRGTMVRAA RALLSAVTRL
160 170 180 190 200
LILADMADVM RLLSHLKIVE EALEAVKNAT NEQDLANRFK EFGKEMVKLN
210 220 230 240 250
YVAARRQQEL KDPHCRDEMA AARGALKKNA TMLYTASQAF LRHPDVAATR
260 270 280 290 300
ANRDYVFKQV QEAIAGISSA AQATSPTDEA KGHTGIGELA AALNEFDNKI
310 320 330 340 350
ILDPMTFSEA RFRPSLEERL ESIISGAALM ADSSCTRDDR RERIVAECNA
360 370 380 390 400
VRQALQDLLS EYMNNTGRKE KGDPLNIAID KMTKKTRDLR RQLRKAVMDH
410 420 430 440 450
ISDSFLETNV PLLVLIEAAK SGNEKEVKEY AQVFREHANK LVEVANLACS
460 470 480 490 500
ISNNEEGVKL VRMAATQIDS LCPQVINAAL TLAARPQSKV AQDNMDVFKD
510 520 530 540 550
QWEKQVRVLT EAVDDITSVD DFLSVSENHI LEDVNKCVIA LQEGDVDTLD
560 570 580 590 600
RTAGAIRGRA ARVIHIINAE MENYEAGVYT EKVLEATKLL SETVMPRFAE
610 620 630 640 650
QVEVAIEALS ANVPQPFEEN EFIDASRLVY DGVRDIRKAV LMIRTPEELE
660 670 680 690 700
DDSDFEQEDY DVRSRTSVQT EDDQLIAGQS ARAIMAQLPQ EEKAKIAEQV
710 720 730 740 750
EIFHQEKSKL DAEVAKWDDS GNDIIVLAKQ MCMIMMEMTD FTRGKGPLKN
760 770 780 790 800
TSDVINAAKK IAEAGSRMDK LARAVADQCP DSACKQDLLA YLQRIALYCH
810 820 830 840 850
QLNICSKVKA EVQNLGGELI VSGTGVQSTF TTFYEVDCDV IDGGRASQLS
860 870 880 890 900
THLPTCAEGA PIGSGSSDSS MLDSATSLIQ AAKNLMNAVV LTVKASYVAS
910 920 930 940 950
TKYQKVYGTA AVNSPVVSWK MKAPEKKPLV KREKPEEFQT RVRRGSQKKH
960
ISPVQALSEF KAMDSF
Length:966
Mass (Da):106,730
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA92DE182CAB1D6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q61301CTNA2_MOUSE
Catenin alpha-2
Ctnna2 Catna2
953Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUZ7A0A0N4SUZ7_MOUSE
Alpha N-catenin
Ctnna2
243Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BS72Q8BS72_MOUSE
Catenin alpha-2
Ctnna2
356Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_017176860.1, XM_017321371.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000160894; ENSMUSP00000124764; ENSMUSG00000063063

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_017176860.1, XM_017321371.1

3D structure databases

SMRiE0CXB9
ModBaseiSearch...

PTM databases

SwissPalmiE0CXB9

Proteomic databases

EPDiE0CXB9
jPOSTiE0CXB9
MaxQBiE0CXB9
PeptideAtlasiE0CXB9
PRIDEiE0CXB9
ProteomicsDBi367514

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8335, 140 antibodies

Genome annotation databases

EnsembliENSMUST00000160894; ENSMUSP00000124764; ENSMUSG00000063063

Organism-specific databases

MGIiMGI:88275, Ctnna2
VEuPathDBiHostDB:ENSMUSG00000063063

Phylogenomic databases

GeneTreeiENSGT01030000234543
OrthoDBi953344at2759
PhylomeDBiE0CXB9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
12386, 0 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ctnna2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063063, Expressed in midbrain and 142 other tissues
ExpressionAtlasiE0CXB9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR001033, Alpha_catenin
IPR030046, CTNNA2
IPR006077, Vinculin/catenin
IPR000633, Vinculin_CS
PANTHERiPTHR18914:SF23, PTHR18914:SF23, 1 hit
PfamiView protein in Pfam
PF01044, Vinculin, 2 hits
PRINTSiPR00805, ALPHACATENIN
SUPFAMiSSF47220, SSF47220, 4 hits
PROSITEiView protein in PROSITE
PS00663, VINCULIN_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE0CXB9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E0CXB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 29, 2021
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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