UniProtKB - D9ZGF6 (D9ZGF6_HUMAN)
Protein
Frizzled-related protein 1
Gene
FRZB
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- Wnt-protein binding Source: Ensembl
GO - Biological processi
- cochlea morphogenesis Source: Ensembl
- convergent extension involved in organogenesis Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of cartilage development Source: Ensembl
- negative regulation of cell development Source: Ensembl
- negative regulation of hepatocyte differentiation Source: Ensembl
- neural crest cell differentiation Source: Ensembl
- somite development Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinARBA annotation |
Biological process | DifferentiationARBA annotation, Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Frizzled-related protein 1ARBA annotationAlternative name(s): FrzB-1ARBA annotation Secreted frizzled-related protein 3ARBA annotation |
Gene namesi | Name:FRZBImported ORF Names:hCG_21961Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000162998.4 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_5014302712 | 33 – 325 | Frizzled-related protein 1Sequence analysisAdd BLAST | 293 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 96 | PROSITE-ProRule annotation | ||
Disulfide bondi | 43 ↔ 89 | PROSITE-ProRule annotation | ||
Disulfide bondi | 112 ↔ 136 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000162998, Expressed in pigmented layer of retina and 218 other tissues |
ExpressionAtlasi | D9ZGF6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 150 | FZInterPro annotationAdd BLAST | 121 | |
Domaini | 178 – 298 | NTRInterPro annotationAdd BLAST | 121 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 297 – 325 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 298 – 325 | PolarSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the secreted frizzled-related protein (sFRP) family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_058446_1_0_1 |
OMAi | SCETVRI |
OrthoDBi | 1339129at2759 |
Family and domain databases
CDDi | cd07441, CRD_SFRP3, 1 hit cd03581, NTR_Sfrp3_like, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035813, NTR_Sfrp3 IPR026556, SFRP3 IPR041759, SFRP3_CRD IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF97, PTHR11309:SF97, 1 hit |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00063, FRI, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50189, NTR, 1 hit |
i Sequence
Sequence statusi: Complete.
D9ZGF6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVCGSPGGML LLRAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM
60 70 80 90 100
TKMPNHLHHS TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF
110 120 130 140 150
QHEPIKPCKS VCERARQGCE PILIKYRHSW PENLACEELP VYDRGVCISP
160 170 180 190 200
EAIVTADGAD FPMDSSNGNC RGASSERCKC KPIRATQKTY FRNNYNYVIR
210 220 230 240 250
AKVKEIKTKC HDVTAVVEVK EILKSSLVNI PRDTVNLYTS SGCLCPPLNV
260 270 280 290 300
NEEYIIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLSK
310 320
SDSSNSDSTQ SQKSGRNSNP RQARN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM015594 Genomic DNA Translation: ADL14515.1 CH471058 Genomic DNA Translation: EAX10958.1 |
RefSeqi | NP_001454.2, NM_001463.3 |
Genome annotation databases
GeneIDi | 2487 |
KEGGi | hsa:2487 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM015594 Genomic DNA Translation: ADL14515.1 CH471058 Genomic DNA Translation: EAX10958.1 |
RefSeqi | NP_001454.2, NM_001463.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3981, 342 antibodies |
DNASUi | 2487 |
Genome annotation databases
GeneIDi | 2487 |
KEGGi | hsa:2487 |
Organism-specific databases
CTDi | 2487 |
VEuPathDBi | HostDB:ENSG00000162998.4 |
Phylogenomic databases
HOGENOMi | CLU_058446_1_0_1 |
OMAi | SCETVRI |
OrthoDBi | 1339129at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2487, 3 hits in 983 CRISPR screens |
ChiTaRSi | FRZB, human |
GenomeRNAii | 2487 |
Gene expression databases
Bgeei | ENSG00000162998, Expressed in pigmented layer of retina and 218 other tissues |
ExpressionAtlasi | D9ZGF6, baseline and differential |
Family and domain databases
CDDi | cd07441, CRD_SFRP3, 1 hit cd03581, NTR_Sfrp3_like, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035813, NTR_Sfrp3 IPR026556, SFRP3 IPR041759, SFRP3_CRD IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF97, PTHR11309:SF97, 1 hit |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00063, FRI, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D9ZGF6_HUMAN | |
Accessioni | D9ZGF6Primary (citable) accession number: D9ZGF6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2010 |
Last sequence update: | October 5, 2010 | |
Last modified: | April 7, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |