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Entry version 52 (05 Jun 2019)
Sequence version 1 (05 Oct 2010)
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Protein

Endoglucanase

Gene

Micau_1672

Organism
Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538 / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.UniRule annotation EC:3.2.1.4

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei461PROSITE-ProRule annotation1
Active sitei470PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidasePROSITE-ProRule annotation, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradationUniRule annotation, Polysaccharide degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MAUR644283:MICAU_RS08345-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM2 Carbohydrate-Binding Module Family 2
CBM3 Carbohydrate-Binding Module Family 3
GH9 Glycoside Hydrolase Family 9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EndoglucanaseUniRule annotation (EC:3.2.1.4UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Micau_1672Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538 / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri644283 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeMicromonospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001908 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42UniRule annotationAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500512745043 – 957EndoglucanaseUniRule annotationAdd BLAST915

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
644283.Micau_1672

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini504 – 649CBM3InterPro annotationAdd BLAST146
Domaini660 – 752Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini762 – 849Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini847 – 957CBM2InterPro annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni738 – 776DisorderedSequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 9 (cellulase E) family.PROSITE-ProRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CYP Bacteria
ENOG410XPC9 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021032

KEGG Orthology (KO)

More...
KOi
K01179

Identification of Orthologs from Complete Genome Data

More...
OMAi
RWLDYWT

Database of Orthologous Groups

More...
OrthoDBi
1226595at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.10, 1 hit
2.60.40.10, 2 hits
2.60.40.290, 1 hit
2.60.40.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001919 CBD2
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR012291 CBM2_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR013783 Ig-like_fold
IPR006311 TAT_signal

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00553 CBM_2, 1 hit
PF00942 CBM_3, 1 hit
PF00041 fn3, 2 hits
PF00759 Glyco_hydro_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00637 CBD_II, 1 hit
SM01067 CBM_3, 1 hit
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF49265 SSF49265, 2 hits
SSF49384 SSF49384, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51173 CBM2, 1 hit
PS51172 CBM3, 1 hit
PS50853 FN3, 2 hits
PS00698 GH9_3, 1 hit
PS51318 TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D9SZU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRPIPPPGG RSRLRRLFAA GAALAVGLAT AVAAPPPASA SAAQAAPAFN
60 70 80 90 100
YAEALQKSLF FYEAQQSGRK PSWNRVSWRG DSALTDGADV GVDLTGGWYD
110 120 130 140 150
AGDHVKFGFP MAFSATMLAW GAVEYRDGYV ASGQLTHLLN NLRFVNDYFV
160 170 180 190 200
KAHPAANVLY GQVGKGDDDH KWWGPAEVMP MARPAYKIDA SCGGADLAGE
210 220 230 240 250
TAAAMAASSM VFRPTDAAYA DKLLGHAKQL YTFADTVRKN YHECITDATS
260 270 280 290 300
FYKSWSGYQD ELVWGAIWLY RATGDATYLA KAESEYDKLG TEPQSTTRSY
310 320 330 340 350
KWTIAWDNKQ FGAYVLLANL TGKQKYVDDA NRWLDYWTVG VNGQRVPYSP
360 370 380 390 400
GGMAVLDSWG ALRYASNTAF AALVYSDRTT DTTRKARYHD FAVRQINYAL
410 420 430 440 450
GDNPRNSSYQ IGFGTNSPRN PHHRTAHGSW WDSQTVPTET RHVLYGALVG
460 470 480 490 500
GPSSANDAYT DSRSDYVMNE VATDYNAGFT SALARLTNEY GGSPRAGFPS
510 520 530 540 550
AETPDMDELT VETTVMQAEP RATGLKAIIY NKSAFPARAL TTGKFRYFFR
560 570 580 590 600
PDGTGPVTVT PGYTQGCPSP STAKQFSGDV WYVEVDCTGY TIAPAGQSQH
610 620 630 640 650
RMEVQFKIGV PEGGTWDPAN DPSYQATAGP NRKVPLYSGG VRVWGEEPGP
660 670 680 690 700
VTPDTTAPTV PGTPVASAVT SSGLTLTWAA STDTGGSGLA GYEITQSQTG
710 720 730 740 750
SDALVLRTAT TNTLAVTGLL PERTYQFTVR ALDGAGNRSA SSAAVSVTTP
760 770 780 790 800
AGPAPDTTPP TAPGTPTASA VGPTGLTLTW GPSTDAVGVT GYRVYRGGNV
810 820 830 840 850
LVGSATGTTL AVTGLTASTT YTFTVVAVDA AGNVSPASPG VTVTTTAPPA
860 870 880 890 900
GGSCAVTWTA NTWDTGFTAN ITVANTGTTA INGWTLAFTF GNSGQKVGQA
910 920 930 940 950
WSANVTQTGT AVTASNLSYN GTLAPGASTS FGFNGTHTGA NPRPTAFTLN

GSACTVS
Length:957
Mass (Da):100,737
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C2CAABE4E4357DC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002162 Genomic DNA Translation: ADL45227.1

NCBI Reference Sequences

More...
RefSeqi
WP_013284865.1, NC_014391.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADL45227; ADL45227; Micau_1672

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32162302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mau:Micau_1672

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002162 Genomic DNA Translation: ADL45227.1
RefSeqiWP_013284865.1, NC_014391.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi644283.Micau_1672

Protein family/group databases

CAZyiCBM2 Carbohydrate-Binding Module Family 2
CBM3 Carbohydrate-Binding Module Family 3
GH9 Glycoside Hydrolase Family 9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL45227; ADL45227; Micau_1672
GeneIDi32162302
KEGGimau:Micau_1672

Phylogenomic databases

eggNOGiENOG4105CYP Bacteria
ENOG410XPC9 LUCA
HOGENOMiHOG000021032
KOiK01179
OMAiRWLDYWT
OrthoDBi1226595at2

Enzyme and pathway databases

BioCyciMAUR644283:MICAU_RS08345-MONOMER

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di1.50.10.10, 1 hit
2.60.40.10, 2 hits
2.60.40.290, 1 hit
2.60.40.710, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001919 CBD2
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR012291 CBM2_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR013783 Ig-like_fold
IPR006311 TAT_signal
PfamiView protein in Pfam
PF00553 CBM_2, 1 hit
PF00942 CBM_3, 1 hit
PF00041 fn3, 2 hits
PF00759 Glyco_hydro_9, 1 hit
SMARTiView protein in SMART
SM00637 CBD_II, 1 hit
SM01067 CBM_3, 1 hit
SM00060 FN3, 2 hits
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49265 SSF49265, 2 hits
SSF49384 SSF49384, 2 hits
PROSITEiView protein in PROSITE
PS51173 CBM2, 1 hit
PS51172 CBM3, 1 hit
PS50853 FN3, 2 hits
PS00698 GH9_3, 1 hit
PS51318 TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD9SZU5_MICAI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D9SZU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 5, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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