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Entry version 71 (16 Oct 2019)
Sequence version 1 (05 Oct 2010)
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Protein

Myelin regulatory factor homolog 2

Gene

myrf-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myelin regulatory factor homolog 2: Constitutes a precursor of the transcription factor (PubMed:28441531). Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531).1 Publication
Myelin regulatory factor homolog 2, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.By similarity
Myelin regulatory factor homolog 2, N-terminal: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531). Specifically required for dorsal D (DD) GABAergic motor neurons synaptic rewiring (PubMed:28441531). Acts in complex with myrf-1 paralog (PubMed:28441531).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi223 – 514NDT80PROSITE-ProRule annotationAdd BLAST292

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Hydrolase, Protease
Biological processDifferentiation, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin regulatory factor homolog 21 Publication (EC:3.4.-.-By similarity)
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myrf-21 PublicationImported
ORF Names:F21A10.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F21A10.2a ; CE23678 ; WBGene00008999 ; myrf-2
F21A10.2b ; CE31488 ; WBGene00008999 ; myrf-2
F21A10.2c ; CE31489 ; WBGene00008999 ; myrf-2
F21A10.2d ; CE18624 ; WBGene00008999 ; myrf-2
F21A10.2e ; CE45261 ; WBGene00008999 ; myrf-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 736CytoplasmicCuratedAdd BLAST736
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei737 – 757HelicalSequence analysisAdd BLAST21
Topological domaini758 – 1009LumenalCuratedAdd BLAST252

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. Worms show normal dorsal D (DD) GABAergic motor neurons rewiring. Worms lacking both myrf-1 and myrf-2 display defective DD neurons rewiring.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004413281 – 1009Myelin regulatory factor homolog 2Add BLAST1009
ChainiPRO_00004413291 – 559Myelin regulatory factor homolog 2, N-terminalBy similarityAdd BLAST559
ChainiPRO_0000441330560 – 1009Myelin regulatory factor homolog 2, C-terminalBy similarityAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi999N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1002N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei559 – 560Cleavage; by autolysisPROSITE-ProRule annotation2

Keywords - PTMi

Autocatalytic cleavage, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
D9PTN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D9PTN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008999 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (By similarity).

Interacts with myrf-1 (PubMed:28441531).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
myrf-1G5EFI72EBI-6727439,EBI-6731843

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3521 myrf-1-myrf-2 complex

Protein interaction database and analysis system

More...
IntActi
D9PTN5, 5 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F21A10.2e

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D9PTN5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini560 – 659Peptidase S74PROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi123 – 151Gln-richPROSITE-ProRule annotationAdd BLAST29
Compositional biasi169 – 174Poly-SerSequence analysis6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecuar Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRF family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3661 Eukaryota
ENOG410XPRK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063626

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D9PTN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVKGACY

Database of Orthologous Groups

More...
OrthoDBi
311898at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026932 MRF_C1
IPR025719 MRF_C2
IPR024061 NDT80_DNA-bd_dom
IPR008967 p53-like_TF_DNA-bd
IPR030392 S74_ICA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit
PF05224 NDT80_PhoG, 1 hit
PF13884 Peptidase_S74, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417 SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51688 ICA, 1 hit
PS51517 NDT80, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform e (identifier: D9PTN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDLNPAETP EPKKNPVAKI ASNLYSTQIV KPVPSVSNST NLSPCQNPNM
60 70 80 90 100
TNLFYITLLQ NKLNKYTQQL LKKNEEGLND PLANVEQFNI IQFLQNDVDF
110 120 130 140 150
NLPIEAFEQG NMDQNIRIDP ILQRQQMANQ PMLMPQHMLQ QLHQQQIYEQ
160 170 180 190 200
QLASMPMTPA ITDLTRHGSS SSPSTTNSDP PYSPEGLNNF GLGTQRPNHG
210 220 230 240 250
VIPNDISNVP QHINRQFNPR MGPNTSPNPP SFPQFLNSNH PTPGSYVQSI
260 270 280 290 300
SPDSNGQGFA QSNLYNALNV SSDESINGSD DIPNRKRPRM DQNMDPSFIM
310 320 330 340 350
HAPVSGKLGA EVTEEGGQPN IRFFKYQEEQ WCPMYDANGE ELGRLQVHVL
360 370 380 390 400
ADKGFNYSTN DNCFVNQKKN HFQVTVKIEA IDPSPPQCFK INGVCKPIEN
410 420 430 440 450
FQLSFVGAKS ESQNSEIPIR QSTTERKPIL HTPVLFKIVE RRMTIVTVPR
460 470 480 490 500
LHFSETTLNN QRKNLRPNPD QKYFNLVVRL YATATDGTTV LMQAFASERV
510 520 530 540 550
IVRATNPGSF EPPEMVDASW NKNGGILSTN GPVVIGKSEP RAQLTVDGDI
560 570 580 590 600
YSSGRVMYPS DIRLKDNITE KGAKDALENL QKLRIVDYFY KPEVASKWGL
610 620 630 640 650
TEDQRKRTGV IAQELAAVLP DAVKDLGDYL TVNESRVFYE TVLATQELCR
660 670 680 690 700
LTGDLDQKID DKVAEISQRL TQYAQKKKML NSMASGLNSE GRSLNASRTS
710 720 730 740 750
LDSSASALTL TNTKKNRRSS RKDKKDAPKS KMTHGTVIGL VGVMAFCLLA
760 770 780 790 800
MSALYILDWH NRNFGYHHFT PSATTSGPKE GPGNVVIPLD HYVPLRQPDA
810 820 830 840 850
PPLVPFCPME TCRGYCCMEY DKDHAELEIT EYDPNTATDN DFGFKADTRS
860 870 880 890 900
DFTLKGFGNN VKISLPELGM QIDERYCIEK SCVKKRKVYS LFIPMTRYLP
910 920 930 940 950
NVPLEVQIDV PSSKVVNNCG YIQEFDNRKC DETGSSSTET DAPRSIQLFD
960 970 980 990 1000
NTFQVSAGQW TQSAYRFRVG YSTELCSIDD THFGGFYEEY NLIFYRACNR

TNSTAINVV
Length:1,009
Mass (Da):113,212
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDD1047BAEC20F9D
GO
Isoform a (identifier: D9PTN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:898
Mass (Da):100,766
Checksum:iDB6B2BFD63199C9B
GO
Isoform b (identifier: D9PTN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGDLNPAETP...KYTQQLLKKN → MVRRPVATRPPK

Show »
Length:947
Mass (Da):106,374
Checksum:i01773F8390FD020C
GO
Isoform c (identifier: D9PTN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGDLNPAETP...KYTQQLLKKN → MLPRNGYPPGYEEF

Show »
Length:949
Mass (Da):106,636
Checksum:iA9D5C2BF50E16C3F
GO
Isoform d (identifier: D9PTN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGDLNPAETP...KYTQQLLKKN → MNSCSTPVS

Show »
Length:944
Mass (Da):105,891
Checksum:i3A2E1187BE9D7F74
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0590611 – 111Missing in isoform a. Add BLAST111
Alternative sequenceiVSP_0590621 – 74MGDLN…LLKKN → MVRRPVATRPPK in isoform b. Add BLAST74
Alternative sequenceiVSP_0590631 – 74MGDLN…LLKKN → MLPRNGYPPGYEEF in isoform c. Add BLAST74
Alternative sequenceiVSP_0590641 – 74MGDLN…LLKKN → MNSCSTPVS in isoform d. Add BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA16508.2
BX284606 Genomic DNA Translation: CAD44121.1
BX284606 Genomic DNA Translation: CAD44122.1
BX284606 Genomic DNA Translation: CBW44371.1
BX284606 Genomic DNA Translation: CBW44372.1

Protein sequence database of the Protein Information Resource

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PIRi
A89624
T21179

NCBI Reference Sequences

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RefSeqi
NP_001257095.1, NM_001270166.1 [D9PTN5-1]
NP_001257096.1, NM_001270167.1 [D9PTN5-5]
NP_509709.2, NM_077308.4 [D9PTN5-4]
NP_741883.1, NM_171761.1 [D9PTN5-3]
NP_741884.1, NM_171762.3 [D9PTN5-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F21A10.2a.1; F21A10.2a.1; WBGene00008999 [D9PTN5-2]
F21A10.2a.2; F21A10.2a.2; WBGene00008999 [D9PTN5-2]
F21A10.2a.3; F21A10.2a.3; WBGene00008999 [D9PTN5-2]
F21A10.2b.1; F21A10.2b.1; WBGene00008999 [D9PTN5-3]
F21A10.2c.1; F21A10.2c.1; WBGene00008999 [D9PTN5-4]
F21A10.2d.1; F21A10.2d.1; WBGene00008999 [D9PTN5-5]
F21A10.2e.1; F21A10.2e.1; WBGene00008999 [D9PTN5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
181229

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F21A10.2

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA16508.2
BX284606 Genomic DNA Translation: CAD44121.1
BX284606 Genomic DNA Translation: CAD44122.1
BX284606 Genomic DNA Translation: CBW44371.1
BX284606 Genomic DNA Translation: CBW44372.1
PIRiA89624
T21179
RefSeqiNP_001257095.1, NM_001270166.1 [D9PTN5-1]
NP_001257096.1, NM_001270167.1 [D9PTN5-5]
NP_509709.2, NM_077308.4 [D9PTN5-4]
NP_741883.1, NM_171761.1 [D9PTN5-3]
NP_741884.1, NM_171762.3 [D9PTN5-2]

3D structure databases

SMRiD9PTN5
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3521 myrf-1-myrf-2 complex
IntActiD9PTN5, 5 interactors
STRINGi6239.F21A10.2e

Proteomic databases

EPDiD9PTN5
PaxDbiD9PTN5

Genome annotation databases

EnsemblMetazoaiF21A10.2a.1; F21A10.2a.1; WBGene00008999 [D9PTN5-2]
F21A10.2a.2; F21A10.2a.2; WBGene00008999 [D9PTN5-2]
F21A10.2a.3; F21A10.2a.3; WBGene00008999 [D9PTN5-2]
F21A10.2b.1; F21A10.2b.1; WBGene00008999 [D9PTN5-3]
F21A10.2c.1; F21A10.2c.1; WBGene00008999 [D9PTN5-4]
F21A10.2d.1; F21A10.2d.1; WBGene00008999 [D9PTN5-5]
F21A10.2e.1; F21A10.2e.1; WBGene00008999 [D9PTN5-1]
GeneIDi181229
KEGGicel:CELE_F21A10.2

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181229
WormBaseiF21A10.2a ; CE23678 ; WBGene00008999 ; myrf-2
F21A10.2b ; CE31488 ; WBGene00008999 ; myrf-2
F21A10.2c ; CE31489 ; WBGene00008999 ; myrf-2
F21A10.2d ; CE18624 ; WBGene00008999 ; myrf-2
F21A10.2e ; CE45261 ; WBGene00008999 ; myrf-2

Phylogenomic databases

eggNOGiKOG3661 Eukaryota
ENOG410XPRK LUCA
GeneTreeiENSGT00530000063626
HOGENOMiHOG000016756
InParanoidiD9PTN5
OMAiQVKGACY
OrthoDBi311898at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D9PTN5

Gene expression databases

BgeeiWBGene00008999 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR026932 MRF_C1
IPR025719 MRF_C2
IPR024061 NDT80_DNA-bd_dom
IPR008967 p53-like_TF_DNA-bd
IPR030392 S74_ICA
PfamiView protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit
PF05224 NDT80_PhoG, 1 hit
PF13884 Peptidase_S74, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51688 ICA, 1 hit
PS51517 NDT80, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYRF2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D9PTN5
Secondary accession number(s): D9PTN4
, G5EF12, Q8MQ67, Q9U3I3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: October 5, 2010
Last modified: October 16, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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