Pbx1

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	233 – 281	HomeoboxPROSITE-ProRule annotationAdd BLAST		49

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-UniRule
DNA-binding transcription factor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotation

Molecular function

DNA-bindingPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Pre-B-cell leukemia transcription factor 1Imported Submitted name: Pre-B-cell leukemia transcription factor 1dImported
Gene namesⁱ	Name:Pbx1Imported Synonyms:PBX1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:97495 Pbx1

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000052534 Expressed in 292 organ(s), highest expression level in rostral migratory stream

Bgeeⁱ

ENSMUSG00000052534 Expressed in 292 organ(s), highest expression level in rostral migratory stream

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	231 – 280	HomeoboxInterPro annotationAdd BLAST		50

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	165 – 185	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0774 Eukaryota ENOG410XRVF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016426

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR005542 PBX
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03792 PBC, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

D9J2V6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI 
        60         70         80         90        100
MTITDQSLDE AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP 
       110        120        130        140        150
TDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGAG SDNSVEHSDY 
       160        170        180        190        200
RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM NLLREQSRTR PISPKEIERM 
       210        220        230        240        250
VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF NKQATEILNE 
       260        270        280        290        300
YFYSHLSNPY PSEEAKEELA KKCGITVSQV DTLRHVISQT GGYSDGLAAS 
       310        320        330 
QMYSPQGISA NGGWQDATTP SSVTSPTEGP GSVHSDTSN

Length:339

Mass (Da):37,048

Last modified:October 5, 2010 - v1

Checksum:ⁱ14256F1FF11C5814

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	P41778	PBX1_MOUSE		Pre-B-cell leukemia transcription f... Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1)	Pbx1 Pbx-1	430	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC093320 Genomic DNA No translation available. AC096625 Genomic DNA No translation available. AC112152 Genomic DNA No translation available. AC116129 Genomic DNA No translation available. HM369110 mRNA Translation: ADK11716.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001278438.1, NM_001291509.1
UniGeneⁱ	Mm.43358 Mm.440114

Genome annotation databases

Ensemblⁱ	ENSMUST00000064438; ENSMUSP00000066385; ENSMUSG00000052534
GeneIDⁱ	18514
UCSC genome browser More...UCSCⁱ	uc007dlg.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D9J2V6	Pre-B-cell leukemia transcription factor 1		HUMAN		339	UniRef100_H0YLF5
PBX homeobox 1		PANTR		339
PBX homeobox 1		PROCO		339
PBX homeobox 1		SAIBB		339
PBX homeobox 1		MACMU		339
+14

Protein	Similar proteins		Species	Score	Length	Source
D9J2V6	Pre-B-cell leukemia transcription factor 1		HUMAN		339	UniRef90_H0YLF5
PBX homeobox 1		PANTR		339
PBX homeobox 1		PROCO		339
PBX homeobox 1		SAIBB		339
PBX homeobox 1		MACMU		339
+16

Protein	Similar proteins		Species	Score	Length	Source
D9J2V6	Homeobox protein ceh-20		CAEEL		338	UniRef50_P41779
CRE-CEH-20 protein		CAERE		353
Uncharacterized protein		CAEBE		338
Protein CBR-CEH-20		CAEBR		338
Uncharacterized protein		Caenorhabditis nigoni		338
+96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC093320 Genomic DNA No translation available. AC096625 Genomic DNA No translation available. AC112152 Genomic DNA No translation available. AC116129 Genomic DNA No translation available. HM369110 mRNA Translation: ADK11716.1
RefSeqⁱ	NP_001278438.1, NM_001291509.1
UniGeneⁱ	Mm.43358 Mm.440114

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000064438; ENSMUSP00000066385; ENSMUSG00000052534
GeneIDⁱ	18514
UCSCⁱ	uc007dlg.2 mouse

Organism-specific databases

CTDⁱ	5087
MGIⁱ	MGI:97495 Pbx1

Phylogenomic databases

eggNOGⁱ	KOG0774 Eukaryota ENOG410XRVF LUCA
GeneTreeⁱ	ENSGT00390000016426

Miscellaneous databases

ChiTaRSⁱ	Pbx1 mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000052534 Expressed in 292 organ(s), highest expression level in rostral migratory stream

Bgeeⁱ

ENSMUSG00000052534 Expressed in 292 organ(s), highest expression level in rostral migratory stream

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR005542 PBX
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03792 PBC, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D9J2V6_MOUSE
Accessionⁱ	D9J2V6Primary (citable) accession number: D9J2V6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 5, 2010
	Last sequence update:	October 5, 2010
	Last modified:	September 12, 2018
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D9J2V6 (D9J2V6_MOUSE)

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Pre-B-cell leukemia transcription factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ