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UniProtKB - D9J2T9 (D9J2T9_MOMBA)

Entry version 78 (16 Oct 2019)
Sequence version 1 (05 Oct 2010)
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Protein
Submitted name:

Ribosome inactivating protein

Gene

RIP

Organism
Momordica balsamina (Bitter gourd) (Balsam apple)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.SAAS annotation EC:3.2.2.22

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei70FructoseCombined sources1
Binding sitei85Beta-D-mannoseCombined sources1
Binding sitei85CDPCombined sources1
Binding sitei85CTPCombined sources1
Binding sitei85UDPCombined sources1
Binding sitei110Beta-D-mannose; via amide nitrogenCombined sources1
Binding sitei111AscorbateCombined sources1
Binding sitei122CTPCombined sources1
Binding sitei163CDPCombined sources1
Binding sitei163CTPCombined sources1
Binding sitei163FructoseCombined sources1
Binding sitei163UDPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi69 – 71UDPCombined sources3
Nucleotide bindingi70 – 71CDPCombined sources2
Nucleotide bindingi70 – 71CTPCombined sources2
Nucleotide bindingi109 – 112CDPCombined sources4
Nucleotide bindingi109 – 112CTPCombined sources4
Nucleotide bindingi109 – 111UDPCombined sources3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseSAAS annotation, Protein synthesis inhibitorSAAS annotation, ToxinSAAS annotation
Biological processPlant defenseSAAS annotation
LigandNucleotide-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ribosome inactivating proteinImported (EC:3.2.2.22Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMomordica balsamina (Bitter gourd) (Balsam apple)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3672 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Cucurbitales › Cucurbitaceae › Momordiceae › Momordica

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi227N-linked (GlcNAc...) asparagineCombined sources1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D9J2T9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni70 – 71Ascorbate bindingCombined sources2
Regioni109 – 111Fructose bindingCombined sources3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.420.10, 1 hit
4.10.470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036041 Ribosome-inact_prot_sf
IPR017989 Ribosome_inactivat_1/2
IPR001574 Ribosome_inactivat_prot
IPR017988 Ribosome_inactivat_prot_CS
IPR016138 Ribosome_inactivat_prot_sub1
IPR016139 Ribosome_inactivat_prot_sub2

The PANTHER Classification System

More...PANTHERi		PTHR33453 PTHR33453, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00161 RIP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00396 SHIGARICIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56371 SSF56371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00275 SHIGA_RICIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D9J2T9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DVSFRLSGAD PSSYGMFIKD LRNALPHTEK VYNIPLLLPS VSGAGRYLLM 
        60         70         80         90        100
HLFNYDGNTI TVAVDVTNVY IMGYLALTTS YFFNEPAADL ASQYVFRSAR 
       110        120        130        140        150
RKITLPYSGN YERLQIAAGK PREKIPIGLP ALDTAISTLL HYDSTAAAGA 
       160        170        180        190        200
LLVLIQTTAE AARFKYIEQQ IQERAYRDEV PSSATISLEN SWSGLSKQIQ 
       210        220        230        240 
LAQGNNGVFR TPTVLVDSKG NRVQITNVTS NVVTSNIQLL LNTKNI
Length:246
Mass (Da):27,069
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B38879C004BB72D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei246Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
HM367595 mRNA Translation: ADK23804.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM367595 mRNA Translation: ADK23804.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MRWX-ray1.70A1-246[»]
3N1NX-ray2.23A1-246[»]
3N2DX-ray2.22A1-246[»]
3N31X-ray2.11A1-246[»]
3N3XX-ray1.70A1-246[»]
3N5DX-ray1.90A1-246[»]
3NFMX-ray2.50A1-246[»]
3NJSX-ray2.10A1-246[»]
3NX9X-ray1.70A1-246[»]
3Q4PX-ray1.80A1-246[»]
3QJIX-ray1.75A1-246[»]
3RL9X-ray1.90A1-246[»]
3S9QX-ray1.67A1-246[»]
3SJ6X-ray1.60A1-246[»]
3U6TX-ray1.85A1-246[»]
3U6ZX-ray1.70A1-246[»]
3U70X-ray2.00A1-246[»]
3U8FX-ray1.80A1-246[»]
3V14X-ray1.70A1-246[»]
3V2KX-ray2.07A1-246[»]
4DWMX-ray1.62A1-246[»]
4EMFX-ray1.77A1-246[»]
4EMRX-ray1.75A1-246[»]
4F9NX-ray2.65A1-246[»]
4FXAX-ray1.70A1-246[»]
4FZ9X-ray1.70A1-246[»]
4GUWX-ray1.60A1-246[»]
4H0ZX-ray2.00A1-246[»]
4HOAX-ray2.00A1-246[»]
4I47X-ray2.65A1-246[»]
4JTBX-ray1.71A1-246[»]
4JTPX-ray1.85A1-246[»]
4K2ZX-ray1.80A1-246[»]
4KL4X-ray1.90A1-246[»]
4KMKX-ray1.65A1-246[»]
4KPVX-ray2.57A1-246[»]
4KWNX-ray1.80A1-246[»]
4L66X-ray1.70A1-246[»]
4LROX-ray1.98A1-246[»]
4LT4X-ray1.69A1-246[»]
4LWXX-ray1.78A1-246[»]
4M5AX-ray1.70A1-246[»]
4O0OX-ray2.59A1-246[»]
4O4QX-ray1.81A1-246[»]
4O8EX-ray2.00A1-246[»]
4Q9FX-ray1.75A1-246[»]
4RZJX-ray1.98A1-246[»]
4XY7X-ray2.50A1-246[»]
4ZT8X-ray1.98A1-246[»]
4ZU0X-ray1.80A1-246[»]
4ZZ6X-ray2.00A1-246[»]
5CIXX-ray1.88A1-246[»]
5CSOX-ray1.78A1-246[»]
5CSTX-ray1.78A1-246[»]
5GM7X-ray1.78A1-246[»]
5GZ7X-ray1.95A1-246[»]
5ILWX-ray1.98A1-246[»]
5ILXX-ray1.70A1-246[»]
5WV1X-ray1.90A1-246[»]
5Y48X-ray1.70A1-246[»]
SMRiD9J2T9
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

Gene3Di3.40.420.10, 1 hit
4.10.470.10, 1 hit
InterProiView protein in InterPro
IPR036041 Ribosome-inact_prot_sf
IPR017989 Ribosome_inactivat_1/2
IPR001574 Ribosome_inactivat_prot
IPR017988 Ribosome_inactivat_prot_CS
IPR016138 Ribosome_inactivat_prot_sub1
IPR016139 Ribosome_inactivat_prot_sub2
PANTHERiPTHR33453 PTHR33453, 1 hit
PfamiView protein in Pfam
PF00161 RIP, 1 hit
PRINTSiPR00396 SHIGARICIN
SUPFAMiSSF56371 SSF56371, 1 hit
PROSITEiView protein in PROSITE
PS00275 SHIGA_RICIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD9J2T9_MOMBA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D9J2T9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 16, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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