UniProtKB - D8UWD8 (SCXN9_MESEU)
Protein
Sodium channel neurotoxin MeuNaTxalpha-9
Gene
N/A
Organism
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Status
Functioni
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.By similarity
GO - Molecular functioni
- sodium channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response Source: InterPro
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel neurotoxin MeuNaTxalpha-91 Publication |
Organismi | Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus) |
Taxonomic identifieri | 34648 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000447452 | 1 – 64 | Sodium channel neurotoxin MeuNaTxalpha-91 PublicationAdd BLAST | 64 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 12 ↔ 63 | By similarity | ||
Disulfide bondi | 16 ↔ 36 | By similarity | ||
Disulfide bondi | 22 ↔ 46 | By similarity | ||
Disulfide bondi | 26 ↔ 48 | By similarity | ||
Modified residuei | 64 | Arginine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 64 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 63 |
Domaini
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).Curated
Sequence similaritiesi
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.Curated
Family and domain databases
CDDi | cd00107, Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR003614, Scorpion_toxin-like IPR036574, Scorpion_toxin-like_sf IPR018218, Scorpion_toxinL IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
PRINTSi | PR00285, SCORPNTOXIN |
SMARTi | View protein in SMART SM00505, Knot1, 1 hit |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863, LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
D8UWD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ARDGYIANDR NCVYTCALNP YCDSECKKNG ADSGYCQWFG RFGNACWCKN
60
LPDKVPIRIP GECRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ249203 mRNA Translation: ADF49575.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ249203 mRNA Translation: ADF49575.1 |
3D structure databases
SMRi | D8UWD8 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00107, Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR003614, Scorpion_toxin-like IPR036574, Scorpion_toxin-like_sf IPR018218, Scorpion_toxinL IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
PRINTSi | PR00285, SCORPNTOXIN |
SMARTi | View protein in SMART SM00505, Knot1, 1 hit |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863, LCN_CSAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCXN9_MESEU | |
Accessioni | D8UWD8Primary (citable) accession number: D8UWD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 3, 2019 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |