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Entry version 31 (02 Jun 2021)
Sequence version 1 (05 Oct 2010)
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Protein

PKD_channel domain-containing protein

Gene

VOLCADRAFT_87992

Organism
Volvox carteri f. nagariensis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.10.3, the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PKD_channel domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:VOLCADRAFT_87992Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVolvox carteri f. nagariensisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3068 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytacore chlorophytesChlorophyceaeCS cladeChlamydomonadalesVolvocaceaeVolvox
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001058 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei463 – 480HelicalSequence analysisAdd BLAST18
Transmembranei501 – 520HelicalSequence analysisAdd BLAST20
Transmembranei535 – 556HelicalSequence analysisAdd BLAST22
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21
Transmembranei637 – 662HelicalSequence analysisAdd BLAST26
Transmembranei763 – 787HelicalSequence analysisAdd BLAST25
Transmembranei936 – 960HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3067.XP_002947772.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini536 – 667PKD_channelInterPro annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni801 – 876DisorderedSequence analysisAdd BLAST76
Regioni1045 – 1069DisorderedSequence analysisAdd BLAST25
Regioni1278 – 1486DisorderedSequence analysisAdd BLAST209

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili909 – 929Sequence analysisAdd BLAST21
Coiled coili1190 – 1217Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi808 – 851Polar residuesSequence analysisAdd BLAST44
Compositional biasi852 – 870Pro residuesSequence analysisAdd BLAST19
Compositional biasi1351 – 1374Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3609, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D8TMS8

Database of Orthologous Groups

More...
OrthoDBi
1732631at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013122, PKD1_2_channel
IPR002153, TRPC_channel

The PANTHER Classification System

More...
PANTHERi
PTHR10117, PTHR10117, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08016, PKD_channel, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D8TMS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLKGGCMS LQAYLLLPIC LRTSCTLRVV WTRRTPSVRG WMWLHHKAAR
60 70 80 90 100
RRSAILSSPH KQAAACKQRA DAIRYGSFVA GINTAGQGIV IVQIDELILG
110 120 130 140 150
SLETSHAFGH RVTFENVDPA SLPHFITCRF AGVTSGQLTW DGVLDYTLAA
160 170 180 190 200
RDGAALRRLI ESHYLDHLLK SQDTVDRVEK VAIANNDPLL MVMLYDHTSI
210 220 230 240 250
EMDLRVLAFL VHSWAVQPLS GRATAGAGSG GGGGGGGSSA FGGTSTWDSA
260 270 280 290 300
FSTRDDDLPD FFDGADPSVN LAARIEEFLV KYVLQRRNPL SATAAIIRAI
310 320 330 340 350
EVGRGLAGVV YADVRNIRLI ERILQPVELP NTVNEVSPLQ VAFDSCDLKF
360 370 380 390 400
MTESLVELYV KVQWLGGELL ALTSHEDPRS LGATNPLLAY GVLKSMGFAG
410 420 430 440 450
KGTMDFLVMA ASRLWHMYVF ASSAFFDSPR GRWSMHALSE LVFLGLYQWQ
460 470 480 490 500
VMFPDMDVRH LQAVHLVFLA FIAGNLVDVA QFVHFRYGSL ARIRRFMADP
510 520 530 540 550
WNALGIVVNG GLAVLTVLKL TQDFGGLPPY KPADAIHMCM ATLAVFVWVR
560 570 580 590 600
ALGIAVPVYP SLGPLLNTVA RMMEELIAFL FPMLIVMTGF STMMTAVYKD
610 620 630 640 650
MIGEYGNFFQ SMLQLFSSIL GNFDFTAFEG LNRTQQLYGI VVLAIFLVIS
660 670 680 690 700
AILLMNLLIA IINNRYRPEE VEAETQFKKA QIVSYYQTQV RRNLVCSPFC
710 720 730 740 750
LTQLALQAAP LLPSGRRNKL SGAARGVWVL GLVPLDGMVL PDDGSDRPTG
760 770 780 790 800
AAELPHLAFL LTLYPMMAVL CISLFLLYTP FGVVQFASKM YSKSIKQYKR
810 820 830 840 850
RMEQHSRRAA PQATSKAQLN VVQQKGAGRT TTTKTTTTTT TTITQVGTAA
860 870 880 890 900
EPSPSPPSPL RPPPQPATPA AAPATAADVE TGATAAAAAA APSPGVVVAR
910 920 930 940 950
SPSSGNDVVK QYQRLKKELQ AEANAAETGL IHFAGYLLAS VFLTVVGLVF
960 970 980 990 1000
YLVVMVLLVL VGWASLYQWV AKVLFSCYNV GVRPFVDMAR ARRRRRRVSP
1010 1020 1030 1040 1050
AAAAAAALHV ASGIGAEAAT AGGGRGAVSV PAGCGTGALF GGGGGGGGGR
1060 1070 1080 1090 1100
SQKDSGAAAA DARADDVGGG VGGAGDVSEQ LYYKQSKARL HWRHAILKVI
1110 1120 1130 1140 1150
ALKNERYLTK RDVLKALAAS KFRLHMAGWD LRVDPRSSSQ DIIESQMQDL
1160 1170 1180 1190 1200
EDDDDPWDDD ELQQDADDDT LESTILEKTE ALTHMVKGGL SAQQAAMESL
1210 1220 1230 1240 1250
MQLVRELSEE VAALRAAPGV TAATEGTDGF GAAAAAALLS PPRPAPPPAT
1260 1270 1280 1290 1300
RPPSAWGLGA ELAVTEGSDV DDAVLLGSGV RQEPELPRPL SSSRSGDGDS
1310 1320 1330 1340 1350
YGGREVTSRR RDTGNAGGRV GSGGIGSSPP PRPPLPATAG RSVAATPPGA
1360 1370 1380 1390 1400
SRAPGSSSSP AASTHGSERR SSSASGGPPR GLDPQMPLER LLDSSGGPDA
1410 1420 1430 1440 1450
LLAAIGTERE RADAAAAGDT SAAKPNFSRT VLEPLRPTGH PVQPVEPPVV
1460 1470 1480
EGSPAAREAA PAAAPKAAAA AAPPPTTPSK QHQGAS
Length:1,486
Mass (Da):158,034
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95C51CAEAABA0749
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL378328 Genomic DNA Translation: EFJ51305.1

NCBI Reference Sequences

More...
RefSeqi
XP_002947772.1, XM_002947726.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9620734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vcn:VOLCADRAFT_87992

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL378328 Genomic DNA Translation: EFJ51305.1
RefSeqiXP_002947772.1, XM_002947726.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3067.XP_002947772.1

Protein family/group databases

TCDBi1.A.4.10.3, the transient receptor potential ca(2+) channel (trp-cc) family

Genome annotation databases

GeneIDi9620734
KEGGivcn:VOLCADRAFT_87992

Phylogenomic databases

eggNOGiKOG3609, Eukaryota
InParanoidiD8TMS8
OrthoDBi1732631at2759

Family and domain databases

InterProiView protein in InterPro
IPR013122, PKD1_2_channel
IPR002153, TRPC_channel
PANTHERiPTHR10117, PTHR10117, 1 hit
PfamiView protein in Pfam
PF08016, PKD_channel, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD8TMS8_VOLCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D8TMS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 2, 2021
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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