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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Nitrospira defluvii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processLipopolysaccharide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCNIT330214:NIDE_RS11720-MONOMER
UniPathwayi
UPA00030

UPA00358;UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotationImported
ORF Names:NIDE2554Imported
OrganismiNitrospira defluviiImported
Taxonomic identifieri330214 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeNitrospira
Proteomesi
  • UP000001660 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi330214.NIDE2554

Structurei

3D structure databases

ProteinModelPortaliD8PG76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
KOiK00979
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

D8PG76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPWDNIDVKR SVTVVIPARY GSSRFPGKPL VELLGKPMIQ HVYEQAQACR
60 70 80 90 100
AVDDVLVATD DERIKTAVQR FGGQVVMTTE PYRTGTDRVA AVAESRTGDC
110 120 130 140 150
FVDLQGDEIL LHPDLITDLV EPFLDSDATM GTLKRQIDSD QDLHNPGVVK
160 170 180 190 200
VTTDREGYAL YFSRAPIPLV RDDPKRAAVP GLHFIHLGLY IYTRDTLQRL
210 220 230 240 250
TALPTGTLEE AEKLEQLRAL ENGMRIRVWE TIHGSLRIDS PEDVPGALKH
260
LHSRATGLGI THS
Length:263
Mass (Da):29,255
Last modified:October 5, 2010 - v1
Checksum:i3E2DFD6023644AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA Translation: CBK42263.1
RefSeqiWP_013249084.1, NC_014355.1

Genome annotation databases

EnsemblBacteriaiCBK42263; CBK42263; NIDE2554
KEGGinde:NIDE2554

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA Translation: CBK42263.1
RefSeqiWP_013249084.1, NC_014355.1

3D structure databases

ProteinModelPortaliD8PG76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330214.NIDE2554

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBK42263; CBK42263; NIDE2554
KEGGinde:NIDE2554

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
KOiK00979
OrthoDBiPOG091H00UN

Enzyme and pathway databases

UniPathwayi
UPA00030

UPA00358;UER00476

BioCyciCNIT330214:NIDE_RS11720-MONOMER

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD8PG76_9BACT
AccessioniPrimary (citable) accession number: D8PG76
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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